91成人版抖音

Dr Angelica Merlot

Senior Lecturer
Medicine & Health
Children's Cancer Institute

Dr Angelica Merlot聽leads聽the Cancer Targets and Therapeutics聽Team聽in the聽聽at Children's Cancer Institute. Angelica聽has not wasted any time establishing her career as a cancer researcher, becoming Australia鈥檚 youngest-ever recipient of a National Health and Medical Research Council fellowship聽in聽2018.

鈥楲ike many Australians, I鈥檝e lost family members to cancer, and it鈥檚 their stories and struggles that inspire me,鈥 she explains. 鈥業 want to do research that improves patient outcomes and survival rates.鈥

Before joining聽the聽Institute in May 2018, Angelica worked at the University of Sydney, developing new anti-cancer drugs聽for particularly聽difficult-to-treat cancers, including pancreatic聽cancer. One of these drugs successfully entered a Phase 1 clinical trial in Australia.

Angelica鈥檚 work is focused on improving our understanding of how tumours grow,聽spread,聽and聽adapt to evade聽anti-cancer therapies, and applying this understanding to develop new drugs and聽strategies that are safer and more effective than current therapies. This involves using nanoparticles to selectively target and kill cancer cells, leaving healthy cells unharmed.

鈥業鈥檓聽very passionate about the work聽we聽do, and very focused on producing outcomes that improve survival rates,鈥櫬爏he says.

In 2019, Angelica was named the Premier鈥檚 Early Career Researcher of the Year (Biological Sciences) and a Tall Poppy Award Winner.聽Awarded the聽,聽she聽is a committed champion for women in science, medicine and technology, and hopes to encourage girls and women to pursue careers in research. To date, she has聽attracted over $2 million in grant funding, and has presented her work at more than 40 conferences in Australia and around the world.

Location
Lowy Cancer Research Centre The University of New South Wales, Sydney, NSW 2052, Australia
  • Journal articles | 2024
    Porter GM; Norris M; Apte M; Merlot A, 2024, 'Abstract C018: Spatial profiling of tumor associated cells expressing endoplasmic reticulum stress proteins predicts poor outcomes in pancreatic cancer patients', Cancer Research, 84, pp. C018 - C018,
    Journal articles | 2019
    Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Sahni S; Huang MLH; Lane DJR; Lok H; Richardson DR, 2019, 'Exploiting cancer metal metabolism using anti-cancer metal- binding agents', Current Medicinal Chemistry, 26, pp. 302 - 322,
    Journal articles | 2019
    Merlot AM; Porter GM; Sahni S; Lim EG; Peres P; Richardson DR, 2019, 'The metastasis suppressor, NDRG1, differentially modulates the endoplasmic reticulum stress response', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1865, pp. 2094 - 2110,
    Journal articles | 2019
    Seebacher NA; Stacy AE; Porter GM; Merlot AM, 2019, 'Clinical development of targeted and immune based anti-cancer therapies', Journal of Experimental and Clinical Cancer Research, 38,
    Journal articles | 2018
    Merlot A; Shafie N; Lim E; Chen A; Sahni S; Yu Y; Richardson D, 2018, 'PO-460 Targeting endoplasmic reticulum stress using thiosemicarbazones to suppress cancer progression', ESMO Open, 3, pp. A202 - A203,
    Journal articles | 2018
    Merlot A; Shafie N; Lim E; Chen A; Sahni S; Yu Y; Richardson D, 2018, 'Cellular metal sequestration and redox stress by thiosemicarbazones induces endoplasmic reticulum stress in tumors to suppress cancer progression', FREE RADICAL BIOLOGY AND MEDICINE, vol. 120, pp. S37 - S37,
    Journal articles | 2016
    Chiang S; Kovacevic Z; Sahni S; Lane DJR; Merlot AM; Kalinowski DS; Huang MLH; Richardson DR, 2016, 'Frataxin and the molecular mechanism of mitochondrial iron-loading in Friedreich's ataxia', Clinical Science, 130, pp. 853 - 870,
    Journal articles | 2016
    Gutierrez EM; Seebacher NA; Arzuman L; Kovacevic Z; Lane DJR; Richardson V; Merlot AM; Lok H; Kalinowski DS; Sahni S; Jansson PJ; Richardson DR, 2016, 'Lysosomal membrane stability plays a major role in the cytotoxic activity of the anti-proliferative agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT)', Biochimica et Biophysica Acta - Molecular Cell Research, 1863, pp. 1665 - 1681,
    Journal articles | 2016
    Kalinowski DS; Stefani C; Toyokuni S; Ganz T; Anderson GJ; Subramaniam NV; Trinder D; Olynyk JK; Chua A; Jansson PJ; Sahni S; Lane DJR; Merlot AM; Kovacevic Z; Huang MLH; Lee CS; Richardson DR, 2016, 'Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics', Biochimica et Biophysica Acta - Molecular Cell Research, 1863, pp. 727 - 748,
    Journal articles | 2016
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Alg眉l H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356', Autophagy, 12, pp. 443,
    Journal articles | 2016
    Klionsky DJ; Abdelmohsen K; Abe A; Abedin MJ; Abeliovich H; Arozena AA; Adachi H; Adams CM; Adams PD; Adeli K; Adhihetty PJ; Adler SG; Agam G; Agarwal R; Aghi MK; Agnello M; Agostinis P; Aguilar PV; Aguirre-Ghiso J; Airoldi EM; Ait-Si-Ali S; Akematsu T; Akporiaye ET; Al-Rubeai M; Albaiceta GM; Albanese C; Albani D; Albert ML; Aldudo J; Alg眉l H; Alirezaei M; Alloza I; Almasan A; Almonte-Beceril M; Alnemri ES; Alonso C; Altan-Bonnet N; Altieri DC; Alvarez S; Alvarez-Erviti L; Alves S; Amadoro G; Amano A; Amantini C; Ambrosio S; Amelio I; Amer AO; Amessou M; Amon A; An Z; Anania FA; Andersen SU; Andley UP; Andreadi CK; Andrieu-Abadie N; Anel A; Ann DK; Anoopkumar-Dukie S; Antonioli M; Aoki H; Apostolova N; Aquila S; Aquilano K; Araki K; Arama E; Aranda A; Araya J; Arcaro A; Arias E; Arimoto H; Ariosa AR; Armstrong JL; Arnould T; Arsov I; Asanuma K; Askanas V; Asselin E; Atarashi R; Atherton SS; Atkin JD; Attardi LD; Auberger P; Auburger G; Aurelian L; Autelli R; Avagliano L; Avantaggiati ML; Avrahami L; Azad N; Awale S; Bachetti T; Backer JM; Bae DH; Bae JS; Bae ON; Bae SH; Baehrecke EH; Baek SH; Baghdiguian S; Bagniewska-Zadworna A, 2016, 'Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)', Autophagy, 12, pp. 1 - 222,
    Journal articles | 2016
    Merlot AM; Sahni S; Lane DJR; Richardsons V; Huang MLH; Kalinowski DS; Richardson DR, 2016, 'Letter to the editor: 鈥淎nalysis of the interaction of Dp44mt with human serum albumin and calf thymus dna using molecular docking and spectroscopic techniques鈥', International Journal of Molecular Sciences, 17,
    Journal articles | 2016
    Merlot AM; Shafie NH; Yu Y; Richardson V; Jansson PJ; Sahni S; Lane DJR; Kovacevic Z; Kalinowski DS; Richardson DR, 2016, 'Mechanism of the induction of endoplasmic reticulum stress by the anti-cancer agent, di-2-pyridylketone 4,4-dimethyl-3-thiosemicarbazone (Dp44mT): Activation of PERK/eIF2伪, IRE1伪, ATF6 and calmodulin kinase', Biochemical Pharmacology, 109, pp. 27 - 47,
    Journal articles | 2016
    Paluncic J; Kovacevic Z; Jansson PJ; Kalinowski D; Merlot AM; Huang MLH; Lok HC; Sahni S; Lane DJR; Richardson DR, 2016, 'Roads to melanoma: Key pathways and emerging players in melanoma progression and oncogenic signaling', Biochimica et Biophysica Acta - Molecular Cell Research, 1863, pp. 770 - 784,
    Journal articles | 2015
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    Journal articles | 2015
    Jansson PJ; Kalinowski DS; Lane DJR; Kovacevic Z; Seebacher NA; Fouani L; Sahni S; Merlot AM; Richardson DR, 2015, 'The renaissance of polypharmacology in the development of anti-cancer therapeutics: Inhibition of the "triad of Death" in cancer by Di-2-pyridylketone thiosemicarbazones', Pharmacological Research, 100, pp. 255 - 260,
    Journal articles | 2015
    Lane DJR; Bae DH; Merlot AM; Sahni S; Richardson DR, 2015, 'Duodenal cytochrome b (DCYTB) in Iron metabolism: An update on function and regulation', Nutrients, 7, pp. 2274 - 2296,
    Journal articles | 2015
    Lane DJR; Merlot AM; Huang MLH; Bae DH; Jansson PJ; Sahni S; Kalinowski DS; Richardson DR, 2015, 'Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease', Biochimica et Biophysica Acta - Molecular Cell Research, 1853, pp. 1130 - 1144,
    Journal articles | 2015
    Liu W; Kovacevic Z; Peng Z; Jin R; Wang P; Yue F; Zheng M; Huang MLH; Jansson PJ; Richardson V; Kalinowski DS; Lane DJR; Merlot AM; Sahni S; Richardson DR, 2015, 'The molecular effect of metastasis suppressors on Src signaling and tumorigenesis: New therapeutic targets', Oncotarget, 6, pp. 35522 - 35541,
    Journal articles | 2015
    Liu W; Yue F; Zheng M; Merlot A; Bae DH; Huang M; Lane D; Jansson P; Liu G; Richardson V; Sahni S; Kalinowski D; Kovacevic Z; Richardson DR, 2015, 'The proto-oncogene c-Src and its downstream signaling pathways are inhibited by the metastasis suppressor, NDRG1', Oncotarget, 6, pp. 8851 - 8874,
    Journal articles | 2015
    Lui GYL; Kovacevic Z; Menezes SV; Kalinowski DS; Merlot AM; Sahni S; Richardson DR, 2015, 'Novel thiosemicarbazones regulate the signal transducer and activator of transcription 3 (stat3) pathway: Inhibition of constitutive and interleukin 6-induced activation by iron depletion', Molecular Pharmacology, 87, pp. 543 - 560,
    Journal articles | 2015
    Lui GYL; Kovacevic Z; Richardson V; Merlot AM; Kalinowski DS; Richardson DR, 2015, 'Targeting cancer by binding iron: Dissecting cellular signaling pathways', Oncotarget, 6, pp. 18748 - 18779,
    Journal articles | 2015
    Merlot AM; Kalinowski DS; Kovacevic Z; Jansson PJ; Lane DJ; Huang MLH; Sahni S; Richardson DR, 2015, 'Making a case for albumin - A highly promising drug-delivery system', Future Medicinal Chemistry, 7, pp. 553 - 556,
    Journal articles | 2015
    Merlot AM; Sahni S; Lane DJR; Fordham AM; Pantarat N; Hibbs DE; Richardson V; Doddareddy MR; Ong JA; Huang MLH; Richardson DR; Kalinowski DS, 2015, 'Potentiating the cellular targeting and anti-tumor activity of Dp44mT via binding to human serum albumin: Two saturable mechanisms of Dp44mT uptake by cells', Oncotarget, 6, pp. 10374 - 10398,
    Journal articles | 2014
    Merlot AM; Kalinowski DS; Richardson DR, 2014, 'Unraveling the mysteries of serum albumin-more than just a serum protein', Frontiers in Physiology, 5 AUG,
    Journal articles | 2014
    Sahni S; Merlot AM; Krishan S; Jansson PJ; Richardson DR, 2014, 'Gene of the month: BECN1', Journal of Clinical Pathology, 67, pp. 656 - 660,
    Journal articles | 2014
    Lane DJR; Merlot AM; Richardson DR, 2014, 'The lure of a LYR: The logistics of iron sulfur cluster delivery', Cell Metabolism, vol. 19, pp. 348 - 350,
    Journal articles | 2014
    Lane DJR; Mills TM; Shafie NH; Merlot AM; Saleh Moussa R; Kalinowski DS; Kovacevic Z; Richardson DR, 2014, 'Expanding horizons in iron chelation and the treatment of cancer: Role of iron in the regulation of ER stress and the epithelial-mesenchymal transition', Biochimica et Biophysica Acta - Reviews on Cancer, vol. 1845, pp. 166 - 181,
    Journal articles | 2013
    Merlot AM; Kalinowski DS; Richardson DR, 2013, 'Novel chelators for cancer treatment: Where are we now?', Antioxidants and Redox Signaling, 18, pp. 973 - 1006,
    Journal articles | 2013
    Merlot AM; Pantarat N; Menezes SV; Sahni S; Richardson DR; Kalinowski DS, 2013, 'Cellular uptake of the antitumor agent Dp44mT occurs via a carrier/receptor-mediated mechanisms', Molecular Pharmacology, vol. 84, pp. 911 - 924,
    Journal articles | 2012
    Serda M; Kalinowski DS; Mrozek-Wilczkiewicz A; Musiol R; Szurko A; Ratuszna A; Pantarat N; Kovacevic Z; Merlot AM; Richardson DR; Polanski J, 2012, 'Synthesis and characterization of quinoline-based thiosemicarbazones and correlation of cellular iron-binding efficacy to anti-tumor efficacy', Bioorganic and Medicinal Chemistry Letters, 22, pp. 5527 - 5531,
    Journal articles | 2010
    Merlot AM; Pantarat N; Lovejoy DB; Kalinowski DS; Richardson DR, 2010, 'Membrane transport and intracellular sequestration of novel thiosemicarbazone chelators for the treatment of cancer', Molecular Pharmacology, vol. 78, pp. 675 - 684,
    Journal articles | 1983
    Bachelet M; Bader C; Merlot A; Laborde K; Snarska J; Ulmann A, 1983, 'Cellular utilization of cytosolic NADPH in kidney and liver cells from rats fed a normal or a vitamin D鈥恉eficient diet', Cell Biochemistry and Function, vol. 1, pp. 25 - 29,
  • Conference Abstracts | 2019
    Merlot AM; Porter G; Sahni S; Lim E; Peres P; Richardson DR, 2019, 'The interactions between the metastasis suppressor, NDRG1, and the endoplasmic reticulum response in cancer cells', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, ITALY, Ferrara, Vol. 139, pp. S37 - S37, presented at Annual Meeting of the Society-for-Free-Radical-Research- Europe (SFRRE) on Redox 91成人版抖音ostasis - From Signaling to Damage, ITALY, Ferrara, 19 June 2019 - 21 June 2019,
    Conference Abstracts | 2019
    Merlot AM; Shafie NH; Porter G; Lim E; Sahni S; Yu Y; Richardson DR, 2019, 'Thiosemicarbazone-induced redox stress stimulates endoplasmic reticulum stress to inhibit cancer proliferation and migration', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, ITALY, Ferrara, Vol. 139, pp. S37 - S38, presented at Annual Meeting of the Society-for-Free-Radical-Research- Europe (SFRRE) on Redox 91成人版抖音ostasis - From Signaling to Damage, ITALY, Ferrara, 19 June 2019 - 21 June 2019,
    Conference Papers | 2018
    Merlot A; Shafie N; Porter G; Sahni S; Richardson D, 2018, 'The formation of redox active complexes is important for the induction of the UPR by Dp44mT', in MOLECULAR CANCER THERAPEUTICS, AMER ASSOC CANCER RESEARCH,
    Conference Papers | 2016
    Merlot AM; Peres P; Sahni S; Richardson DR, 2016, 'Dissecting the Role of the Iron-Regulated Metastasis Suppressor NDRG1 in Regulating Endoplasmic Reticulum Stress and Cancer Cell Survival', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S126 - S126,
    Conference Papers | 2016
    Merlot AM; Shafie N; Yu Y; Kalinowski DS; Richardson DR, 2016, 'The Redox Active Anti-Cancer Drug, Dp44mT, Induces Endoplasmic Reticulum Stress Activating Pro-Apoptotic Pathways of the Unfolded Protein Response in Cancer Cells', in FREE RADICAL BIOLOGY AND MEDICINE, ELSEVIER SCIENCE INC, pp. S126 - S126,
    Conference Papers | 2014
    Merlot AM; Fordham AM; Sahni S; Pantarat N; Kalinowski DS; Richardson DR, 2014, 'EXPLOITING HSA TO STIMULATE THE DELIVERY AND ANTI-TUMOUR ACTIVITY OF THE ANTI-CANCER THIOSEMICARBAZONE, DP44MT, TO CANCER CELLS', in ASIA-PACIFIC JOURNAL OF CLINICAL ONCOLOGY, WILEY-BLACKWELL, pp. 19 - 19,
    Conference Papers | 2013
    Kalinowski D; Merlot A; Pantarat N; Menezes S; Doddareddy M; Hibbs D; Richardson DR, 2013, 'THE INTERACTION OF NOVEL ANTI-CANCER IRON CHELATORS WITH ALBUMIN: MECHANISMS OF CELLULAR UPTAKE', in AMERICAN JOURNAL OF HEMATOLOGY, WILEY-BLACKWELL, pp. E169 - E169,
    Conference Papers | 2012
    Merlot AM; Kalinowski DS; Pantarat N; Menezes S; Doddareddy M; Hibbs D; Richardson DR, 2012, 'Transport of the Anticancer Agent, Dp44mT, via a Receptor-mediated Process', in EUROPEAN JOURNAL OF CANCER, ELSEVIER SCI LTD, IRELAND, European Org Res & Treatment Canc (EORTC), Dublin, pp. 36 - 36, presented at 24th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, IRELAND, European Org Res & Treatment Canc (EORTC), Dublin, 06 November 2012 - 09 November 2012,
    Conference Papers | 2011
    Merlot AM; Kalinowski DS; Pantarat N; Doddareddy M; Hibbs DE; Richardson DR, 2011, 'Abstract A112: Enhanced accumulation of anticancer drug in tumor cells through albumin interactions: A novel drug delivery mechanism.', in Molecular Cancer Therapeutics, American Association for Cancer Research (AACR), pp. A112 - A112, presented at Abstracts: AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics--Nov 12-16, 2011; San Francisco, CA,

2024 Tour de Cure Grant

2024 UNSW Cancer Seed Grant

2023 Infrastructure Grant UNSW

2022 Infrastructure Grant UNSW

2021 Infrastructure Grant UNSW

2020聽PdCCRS聽Cancer Australia/Cure Cancer Australia Grant

2019 NSW Early Career Researcher of the Year (Biological Sciences)

2019 Tall Poppy Award

2019 NSW Young Woman of the Year

2019 Tour de Cure Grant

2018聽PdCCRS聽Cancer Australia/Cure Cancer Australia Grant

2019 International Outstanding Speaker Award SFRRE

2019 International Young Investigator Award SFRRI

2018 Scientia Research Fellow

2016 NHMRC Peter Doherty Fellowship

2016 CINSW ECR Fellowship