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Dr Jennifer Snaith

Dr Jennifer Snaith

Conjoint Lecturer

FRACP, MBBS (Hons), BMedSci

Medicine & Health
School of Clinical Medicine

Dr Jennifer Snaith is an Endocrinologist and Research Fellow based at the Garvan Institute of Medical Research where she conducts clinical trials in type 1 diabetes as part of the AUSTAG group. Her career mission is to improve the lives of people living with type 1 diabetes through clinical service, advocacy and innovative research.

She is a Staff Specialist Endocrinologist at St Vincent's Hospital, and established with her team (Marhava/Lum/Higgins), the Diabetes in Youth (DIY) service in 2021. Her research activities are clinically based and relate to type 1 diabetes, insulin resistance, adjunctive therapies and cardiometabolic risk.

During her PhD candidature (primary supervisor Greenfield) Dr Snaith conducted the INTIMET study (INsulin resistance in type 1 diabetes managed with METformin) and was a recipient of the National Health and Medical Research Council (NHMRC) Post Graduate Scholarship, and Diabetes Australia top up scholarship. The INTIMET study was a placebo controlled randomised controlled clinical examining the impact of metformin on hepatic and muscle insulin resistance, assessed using hyperinsulinaemic euglycaemic clamps.

The RESET1 study (Reducing Cardiometabolic Risk with Semaglutide in Type 1 Diabetes) is the second clinical trial from the AUSTAG group. Snaith was awarded the Diabetes Australia Coghlan Award for Emerging Researchers, and the Rebecca Davies Fellowship from JDRF Australia to conduct this randomised placebo controlled clinical trial to examine the effect of semaglutide on cardiovascular risk in adults with type 1 diabetes. Trial registration:https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=386649&isReview=true

The TIRTLE study (Tirzepatide in Type 1 Diabetes: Cardiometabolic Effects) is a tirzepatide in type 1 diabetes placebo controlled trial (due for completion Dec 2024). Trial registration:https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=386985&isReview=true

Prof Jerry Greenfield and Dr Snaith established the Garvan Institute 'Australian Type 1 Diabetes Mellitus Adjuncts Group' (AUSTAG). The AUSTAG mission is to prolong the life of Australians living with type 1 diabetes by preventing cardiovascular disease through novel repurposing of cardioprotective medications. AUSTAG specialise in the conduct of clinical trials in type 1 diabetes. These studies include detailed mechanistic studies, to phenotype metabolic health in type 1 diabetes, and the physiological impacts of adjunctive therapies on cardiometabolic health in type 1 diabetes.

  • Book Chapters | 2021
    Lasschuit JWJ; Snaith JR; Frew JW, 2021, 'The skin and diabetes', in Skin and the Heart, pp. 283 - 298,
    Book Chapters | 2021
    Lasschuit JWJ; Snaith JR; Frew JW, 2021, 'The skin and diabetes', in Skin and the Heart, pp. C1,
  • Journal articles | 2024
    FRAMPTON R; SNAITH JR; HOCKING SL; GREENFIELD J, 2024, '787-P: Reducing Cardiometabolic Risk with Semaglutide in Type 1 Diabetes (RESET1)—A Double-Blinded Randomized Placebo-Controlled Trial (Study Protocol)', Diabetes, 73,
    Journal articles | 2024
    Forner P; Snaith J; Greenfield JR, 2024, 'Prescribing patterns of adjunctive therapy for the treatment of type 1 diabetes mellitus among Australian endocrinologists', Internal Medicine Journal, 54, pp. 779 - 785,
    Journal articles | 2024
    Frampton R; Snaith JR; Hocking S; Holmes-Walker J; Olsen N; Greenfield JR, 2024, 'Reducing cardiometabolic risk with semaglutide in type 1 diabetes (RESET1): Study protocol of a phase 2double-blinded randomised placebo-controlled trial', Diabetic Medicine, 41,
    Journal articles | 2024
    JANUSZEWSKI AS; SNAITH JR; KOWALSKI GM; BRUCE C; HOLMES-WALKER J; JENKINS A; GREENFIELD J, 2024, '1607-P: Estimation of Muscle and Hepatic Insulin Sensitivity in Type 1 Diabetes Adults Using Clinical and Research Biomarkers', Diabetes, 73,
    Journal articles | 2024
    Lamaro BD; Greenfield JR; Snaith JR, 2024, 'Can Unmet Needs Be Addressed by Adjunctive Therapies? Findings from a Patient Perspectives Survey in Adults with Type 1 Diabetes', Journal of Patient Experience, 11,
    Journal articles | 2024
    SNAITH JR; OLSEN ND; KOWALSKI GM; BRUCE C; EVANS JL; JANUSZEWSKI AS; JENKINS A; BREIT SN; HOLMES-WALKER J; GREENFIELD J, 2024, '865-P: Metformin Reduces Insulin Dose and Visceral Fat Accumulation, and Increases GDF15 without Reducing Insulin Resistance in Adults with Type 1 Diabetes—A 26-Week, Randomized, Double-Blind Placebo-Controlled Trial (INTIMET)', Diabetes, 73,
    Journal articles | 2023
    Snaith JR; Greenfield JR; Malozowski S; Weghuber D; Kelly AS; Arslanian S, 2023, 'Once-Weekly Semaglutide in Adolescents with Obesity', New England Journal of Medicine, 388, pp. 1145,
    Journal articles | 2023
    Snaith JR; Olsen N; Kowalski G; Bruce C; Holmes-Walker J; Greenfield JR, 2023, 'OR18-03 Peripheral But Not Hepatic Insulin Resistance Associates With Adverse Vascular And Metabolic Health In Type 1 Diabetes: A Possible Target For Adjunctive Therapy', Journal of the Endocrine Society, 7,
    Journal articles | 2022
    Snaith JR; Greenfield JR, 2022, 'Sodium–glucose cotransporter 2 inhibitors in type 1 diabetes: a missed opportunity for cardiovascular protection?', Medical Journal of Australia, 217, pp. 126 - 128,
    Journal articles | 2021
    Snaith JR; Danta M; Greenfield JR, 2021, 'Metabolic dysfunction-associated fatty liver disease and insulin resistance in type 1 diabetes', The Lancet Gastroenterology and Hepatology, 6, pp. 985 - 986,
    Journal articles | 2021
    Snaith JR; Holmes-Walker DJ, 2021, 'Technologies in the management of type 1 diabetes', Medical Journal of Australia, 214, pp. 202 - 205.e1,
    Journal articles | 2021
    Snaith JR; Samocha-Bonet D; Evans J; Liu Z; Kowalski G; Bruce C; Holmes-Walker DJ; Greenfield JR, 2021, 'Insulin resistance in type 1 diabetes managed with metformin (INTIMET): Study protocol of a double-blind placebo-controlled, randomised trial', Diabetic Medicine, 38,
    Journal articles | 2020
    Htet TD; Godneva A; Liu Z; Chalmers E; Kolobkov D; Snaith JR; Richens R; Toth K; Danta M; Hng TM; Elinav E; Segal E; Greenfield JR; Samocha-Bonet D, 2020, 'Rationale and design of a randomised controlled trial testing the effect of personalised diet in individuals with pre-diabetes or type 2 diabetes mellitus treated with metformin', BMJ Open, 10, pp. e037859,
    Journal articles | 2020
    Snaith JR; Gao B; Chipps D; Girgis CM, 2020, 'Massive adrenal hyperplasia from paraneoplastic adrenocorticotropic hormone', BMJ Case Reports, 13,
    Journal articles | 2020
    Snaith JR; Greenfield JR, 2020, 'COVID-19: it's changed us', Internal Medicine Journal, 50, pp. 1162 - 1163,
    Journal articles | 2020
    Snaith JR; Holmes-Walker DJ; Greenfield JR, 2020, 'Letter to the editor: ⇜risk factors for cardiovascular disease (CVD) in adults with type 1 diabetes: findings from prospective real-life T1D exchange registry”', Journal of Clinical Endocrinology and Metabolism, 105, pp. 1 - 2,
    Journal articles | 2020
    Snaith JR; Holmes-Walker DJ; Greenfield JR, 2020, 'Reducing Type 1 Diabetes Mortality: Role for Adjunctive Therapies?', Trends in Endocrinology and Metabolism, 31, pp. 150 - 164,
    Journal articles | 2020
    Snaith JR; McLeod D; Richardson A; Chipps D, 2020, 'Multifocal insulinoma secondary to insulinomatosis: persistent hypoglycaemia despite total pancreatectomy', ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS,
    Journal articles | 2020
    Snaith JR; Samocha-Bonet D; Holmes-Walker DJ; Greenfield JR, 2020, 'MON-LB113 Insulin Resistance in Type 1 Diabetes Managed With Metformin (INTIMET): Rationale and Study Design of a Randomised Placebo-Controlled Trial', Journal of the Endocrine Society, 4,
    Journal articles | 2019
    Kim A; Snaith JR; Mahajan H; Holmes-Walker DJ, 2019, 'Nesidioblastosis following laparoscopic sleeve gastrectomy', Clinical Endocrinology, 91, pp. 906 - 908,
    Journal articles | 2019
    Snaith JR; Holmes-Walker DJ; Girgis CM; Greenfield JR, 2019, 'Excess mortality and cardiovascular disease risk in type 1 diabetes', The Lancet, 393, pp. 984 - 985,
    Journal articles | 2019
    Snaith JR; Holmes-Walker DJ; Greenfield JR, 2019, 'Association of insulin dose, cardiometabolic risk factors, and cardiovascular disease in type 1 diabetes during 30 years of follow-up in the DCCT/EDIC study. Diabetes care 2019;42:657-664', Diabetes Care, 42, pp. E135 - E136,
    Journal articles | 2017
    Chi C; Snaith J; Gunton JE, 2017, 'Diabetes Medications and Cardiovascular Outcomes in Type 2 Diabetes', Heart Lung and Circulation, 26, pp. 1133 - 1141,
    Journal articles | 2016
    Snaith J; Burns K; Kok J; Chen S; Cheung NW, 2016, 'A case of rhino-orbital mucormycosis in diabetes with haematogenous cerebral spread', Medical Mycology Case Reports, 13, pp. 22 - 24,
  • Preprints | 2023
    Snaith JR; Olsen N; Greenfield JR, 2023, Statistical Analysis Plan for the INTIMET study (Insulin Resistance in Type 1 Diabetes Managed with Metformin), ,
    Conference Abstracts | 2022
    Snaith JR; Holmes-Walker DJ; Greenfield JR, 2022, 'Insulin resistance and visceral or ectopic fat deposition may independently determine metabolic and cardiovascular complications in type 1 diabetes', in DIABETOLOGIA, SPRINGER, SWEDEN, Stockholm, Vol. 65, pp. S83 - S83, presented at 58th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), SWEDEN, Stockholm, 19 September 2022 - 23 September 2022,
    Conference Papers | 2017
    Lee MA; Chipps D; Chi WC; Snaith J; Wong V, 2017, 'What guidelines don't tell you: hypoglycaemia following glucagon administration in a patient with an insulinoma', in CLINICAL ENDOCRINOLOGY, WILEY-BLACKWELL, pp. 18 - 18,
    Conference Papers | 2017
    Snaith J; Chipps D, 2017, 'Unusual patterns of endocrine irAEs in patients receiving checkpoint inhibitor immunotherapies', in CLINICAL ENDOCRINOLOGY, WILEY, AUSTRALIA, Perth, pp. 82 - 82, presented at Joint Annual Scientific Meetings of Endocrine-Society-of-Australia (ESA) and Society-for-Reproductive-Biology (SRB), AUSTRALIA, Perth, 27 August 2017 - 30 August 2017,
    Conference Papers | 2017
    Snaith J; Chipps D, 2017, 'Will this ever end? Recurrent hypoglycaemia due to insulinomatosis', in CLINICAL ENDOCRINOLOGY, WILEY, AUSTRALIA, Perth, pp. 86 - 86, presented at Joint Annual Scientific Meetings of Endocrine-Society-of-Australia (ESA) and Society-for-Reproductive-Biology (SRB), AUSTRALIA, Perth, 27 August 2017 - 30 August 2017,
    Conference Papers | 2017
    Snaith J; Stojanovska V; Padmanabhan S; Cheung NW, 2017, 'An assessment of adequate hypoglycaemia and safety of the insulin tolerance test', in CLINICAL ENDOCRINOLOGY, WILEY-BLACKWELL, pp. 62 - 62,

2024 - Australian Diabetes Society Lindsey Baudinet Rising Star Award in Type 1 Diabetes Research

2023 - Diabetes Australia Coghlan Award, for project 'Reducing Cardiometabolic Risk with Semaglutide in Type 1 Diabetes (RESET1)'

2022 - JDRF Rebecca Davies Fellowship

2022 - Australian Diabetes Society Clinical Young Investigator's Award

2021 - UNSW ARC Postgraduate Council Research Student Award

2020 - UNSW Visualise Your Thesis (Runner Up)

2020- NHMRC Post Graduate Scholarship

2020- NHMRC/Diabetes Australia co-funding award

2019- UNSW University Post Graduate Award

2018 - Joan Waugh Scholarship for academic excellence and leadership potential

2018 - Westmead Association Tracey Robinson Registrar Award for Excellence in Teaching

2017 - Westmead Association Advanced Trainee of the Year

2015 - WestmeadAssociation Tracey Robinson Registrar Award for Excellence in Teaching

2007 - University of Sydney Exchange Scholarship

2005 - Medical Science Scholarship

2024

  • St Vincent’s Clinic Foundation Annual Grant $50,000,Snaith, JR (CI-A), Frampton R, Samocha-Bonet D, Greenfield JR, A Phase II study examining the effects of adjunctive tirzepatide on weight, metabolism and cardiovascular risk in adults with type 1 diabetes and obesity (the TIRTLE study)
  • Australian Diabetes Society Lindsey Baudinet Rising Star in Type 1 Diabetes Award $20,000,Snaith JR (CI-A), Towards combo therapy: Tirzepatide for weight, metabolism and CV risk in adults with T1D and obesity (a phase II trial)'.
  • MRFF 2023 TTRACardiovascular Disease and Diabetes Mechanisms $916,315:Greenfield JR, Snaith JR (CI-B), Repurposed Semaglutide to Bridgethe T1DCardiovascular Risk Gap

2023

  • Diabetes Australia Coghlan Award $150,000,Snaith JR (CI-A), Reducing Cardiometabolic Risk with Semaglutide in Type 1 Diabetes (RESET1)

2022

  • JDRF Rebecca Davies Fellowship $142,500,Snaith JR (CI-A), Reducing Cardiometabolic Risk with Semaglutide in Type 1 Diabetes (RESET1)
  • University of New South Wales Infrastructure Grant $200,651,Samocha-Bonet D, Snaith JR (CI-B), Greenfield JR, Chen R, Danta M, Jabbour A, Lim E, Patel S. BodPod and Q-NRG for extensive metabolic phenotyping

2021

  • St Vincent’s Curran Foundation Endowment Grant $10,930,Snaith JR (CI-A), ‘Introducing rapid point of care HbA1c (Haemoglobin A1c) tests to SVH diabetes clinics’
  • Cardiac, Vascular and Metabolic Medicine Theme Networking Seed Grant $30,000,Snaith JR (CI-A), Liu Z, Lovell N, Greenfield JR, ‘A novel online tool to diagnose double diabetes using biomarkers: towards cardiovascular risk reduction by personalised adjunctive treatment of insulin resistance in type 1 diabetes’

2020

  • St Vincent’s Clinic Foundation Tancred Grant $50,000,Greenfield JR, Snaith J (CI-B), Holmes-Walker J, Girgis C, ‘INTIMET – Insulin Resistance in Type 1 Diabetes Managed with Metformin’

2019

  • Diabetes Australia Millennium Grant (Type 1 Diabetes) $150,000,Greenfield JR, Snaith J (CI-B), Holmes Walker JR, Girgis C, Samocha-Bonet D, ‘Phenotypic Characterisation of Insulin-Sensitive and Insulin-Resistant Adults with Type 1 Diabetes’

My Research Supervision

UNSW PhD

  • Dr R.Frampton: The Incretin Signature and the Role ofSemaglutide in Type 1 Diabetes

UNSW Medicine Honours

  • J.Yang: Repurposing Adjunctive Therapies in Type 1 Diabetes: APatient Experience Survey

Previous research supervision:

UNSW Medicine Honours (B.Lamaro): An Unmet Needs Assessment in Type 1 Diabetes Mellitius: Rationale for Adjunctive Therapies?