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Dr Jonathan Berengut

Dr Jonathan Berengut

Research Associate
Medicine & Health
School of Biomedical Sciences

I am a researcher who works primarily in the field of DNA nanotechnology. We build things out of DNA. But I don鈥檛 mean this in the same way that most molecular biologists build things with DNA -where DNA codes for amino acids, which fold into proteins. I mean we use DNA as a physical building material to construct very very small (nanometre scale) structures. This is possible because DNA strands have a simple set of rules that determine how the individual nucleotides stick together; 鈥楢鈥 base-pairs with 鈥楾鈥, and 鈥楥鈥 with 鈥楪鈥.聽By carefully designing the sequences of single-stranded DNA, we can therefore control exactly how these strands come together to form the desired shape or structure.聽I use a particular technique called 鈥楧NA origami鈥, which uses hundreds of these short synthetic DNA strands to efficiently 鈥榝old鈥 a longer strand into a complex structure. These structures can be 2D or 3D and tend to be in the order of tens to hundreds of nanometres in size. The designs can be flexible or rigid, and can include pivots, hinges, and sequence-specific binding sites. Because of this, they鈥檙e often used as 鈥榥ano-breadboards鈥 to spatially organise molecules like proteins and nanoparticles very precisely. This allows us to build stuff like multi-enzyme nanoreactors and plasmonic nanodevices. I鈥檓 also super interested in building DNA origami nanobots that assemble themselves into specific formations, which I hope will one day give us new methods of controlling matter at the nanoscale.

Location
Lowy Cancer Research Centre Level 3
  • Journal articles | 2024
    Berengut JF; Berg WR; Rizzuto FJ; Lee LK, 2024, 'Passivating Blunt-Ended Helices to Control Monodispersity and Multi-Subunit Assembly of DNA Origami Structures', Small Structures, 5,
    Journal articles | 2024
    Berengut JF; Berg WR; Rizzuto FJ; Lee LK, 2024, 'Passivating Blunt鈥怑nded Helices to Control Monodispersity and Multi鈥怱ubunit Assembly of DNA Origami Structures', Small Structures, 5,
    Journal articles | 2024
    Luu MT; Berengut JF; Li J; Chen JB; Singh JKD; Glieze KCD; Turner M; Skipper K; Meppat S; Fowler H; Close W; Doye JPK; Abbas A; Wickham SFJ, 2024, 'Reconfigurable nanomaterials folded from multicomponent chains of DNA origami voxels', Science Robotics, 9,
    Journal articles | 2024
    Yang Y; Ma Y; Berengut JF; Lee LK; Tilley RD; Gaus K; Gooding JJ, 2024, 'Electrochemically controlled blinking of fluorophores for quantitative STORM imaging', Nature Photonics, 18, pp. 713 - 720,
    Journal articles | 2023
    Berg WR; Berengut JF; Bai C; Wimberger L; Lee LK; Rizzuto FJ, 2023, 'Light-Activated Assembly of DNA Origami into Dissipative Fibrils', Angewandte Chemie - International Edition, 62,
    Journal articles | 2023
    Berg WR; Berengut JF; Bai C; Wimberger L; Lee LK; Rizzuto FJ, 2023, 'Light鈥怉ctivated Assembly of DNA Origami into Dissipative Fibrils', Angewandte Chemie, 135,
    Journal articles | 2023
    Hendrikse SIS; Todorova N; Soleimaninejad H; Charchar P; Sani MA; Al Taief K; Berengut JF; Wickham SFJ; Gras SL; Fahrenbach AC; Thordarson P; Ellis AV, 2023, 'Exploring Artificial Nucleic Acid Mimicking Peptide Nanofibers', Chemistry of Materials, 35, pp. 4355 - 4365,
    Journal articles | 2023
    Wintersinger CM; Minev D; Ershova A; Sasaki HM; Gowri G; Berengut JF; Corea-Dilbert FE; Yin P; Shih WM, 2023, 'Author Correction: Multi-micron crisscross structures grown from DNA-origami slats (Nature Nanotechnology, (2023), 18, 3, (281-289), 10.1038/s41565-022-01283-1)', Nature Nanotechnology,
    Journal articles | 2023
    Wintersinger CM; Minev D; Ershova A; Sasaki HM; Gowri G; Berengut JF; Corea-Dilbert FE; Yin P; Shih WM, 2023, 'Multi-micron crisscross structures grown from DNA-origami slats', Nature Nanotechnology, 18, pp. 281 - 289,
    Journal articles | 2022
    Brown JWP; Alford RG; Walsh JC; Spinney RE; Xu SY; Hertel S; Berengut JF; Spenkelink LM; Van Oijen AM; B枚cking T; Morris RG; Lee LK, 2022, 'Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor', ACS Nano, 16, pp. 6455 - 6467,
    Journal articles | 2022
    Montgomery K; Williams TJ; Brettle M; Berengut JF; Zhang E; Zaugg J; Hugenholtz P; Ferrari BC, 2022, 'Corrigendum to: Persistence and resistance: survival mechanisms of Candidatus Dormibacterota from nutrient-poor Antarctic soils (Environmental Microbiology, (2021), 23, 8, (4276-4294), 10.1111/1462-2920.15610)', Environmental Microbiology, 24, pp. 4491 - 4491,
    Journal articles | 2021
    Ji M; Williams TJ; Montgomery K; Wong HL; Zaugg J; Berengut JF; Bissett A; Chuvochina M; Hugenholtz P; Ferrari BC, 2021, 'Candidatus Eremiobacterota, a metabolically and phylogenetically diverse terrestrial phylum with acid-tolerant adaptations', ISME Journal, 15, pp. 2692 - 2707,
    Journal articles | 2021
    Montgomery K; Williams TJ; Brettle M; Berengut JF; Angelique E; Zhang E; Zaugg J; Hugenholtz P; Ferrari BC; Ray A, 2021, 'Persistence and resistance: survival mechanisms of Candidatus Dormibacterota from nutrient-poor Antarctic soils', Environmental Microbiology, 23, pp. 4276 - 4294,
    Journal articles | 2021
    Singh JKD; Luu MT; Berengut JF; Abbas A; Baker MAB; Wickham SFJ, 2021, 'Minimizing cholesterol-induced aggregation of membrane-interacting dna origami nanostructures', Membranes, 11,
    Journal articles | 2021
    Williams TJ; Allen MA; Berengut JF; Cavicchioli R, 2021, 'Shedding Light on Microbial 鈥淒ark Matter鈥: Insights Into Novel Cloacimonadota and Omnitrophota From an Antarctic Lake', Frontiers in Microbiology, 12,
    Journal articles | 2020
    Berengut JF; Wong CK; Berengut JC; Doye JPK; Ouldridge TE; Lee LK, 2020, 'Self-Limiting Polymerization of DNA Origami Subunits with Strain Accumulation', ACS Nano, 14, pp. 17428 - 17441,
    Journal articles | 2019
    Baker M; Nieves D; Hilzenrat G; Berengut J; Gaus K; Lee L, 2019, 'Stoichiometric quantification of spatially dense assemblies with qPAINT', ,
    Journal articles | 2019
    Baker MAB; Nieves DJ; Hilzenrat G; Berengut JF; Gaus K; Lee LK, 2019, 'Stoichiometric quantification of spatially dense assemblies with qPAINT', Nanoscale, 11, pp. 12460 - 12464,
    Journal articles | 2019
    Berengut JF; Berengut JC; Doye JPK; Pre拧ern D; Kawamoto A; Ruan J; Wainwright MJ; Lee LK, 2019, 'Design and synthesis of pleated DNA origami nanotubes with adjustable diameters', Nucleic Acids Research, 47, pp. 11963 - 11975,
    Journal articles | 2018
    Baker MAB; Tuckwell AJ; Berengut JF; Bath J; Benn F; Duff AP; Whitten AE; Dunn KE; Hynson RM; Turberfield AJ; Lee LK, 2018, 'Dimensions and Global Twist of Single-Layer DNA Origami Measured by Small-Angle X-ray Scattering', ACS Nano, 12, pp. 5791 - 5799,
    Journal articles | 2016
    Milligan MJ; Harvey E; Yu A; Morgan AL; Smith DL; Zhang E; Berengut J; Sivananthan J; Subramaniam R; Skoric A; Collins S; Damski C; Morris KV; Lipovich L, 2016, 'Global intersection of long non-coding RNAs with processed and unprocessed pseudogenes in the human genome', Frontiers in Genetics, 7,
  • Preprints | 2024
    Luu MT; Berengut JF; Daljit Singh JK; Coffi Dit Glieze K; Turner M; Skipper K; Meppat S; Fowler H; Close W; Doye JPK; Abbas A; Wickham SFJ, 2024, Reconfigurable multi-component nanostructures built from DNA origami voxels,
    Preprints | 2023
    Berengut JF; Berg WR; Rizzuto FJ; Lee LK, 2023, Passivating blunt-ended helices to control monodispersity and multi-subunit assembly of DNA origami structures,
    Preprints | 2022
    Brown JWP; Alford R; Walsh J; Spinney R; Xu S; Hertel S; Berengut J; Spenkelink L; van Oijen A; B枚cking T; Morris R; Lee L, 2022, Rapid exchange of stably bound protein and DNA cargo on a DNA origami receptor,
    Preprints | 2022
    Wintersinger CM; Minev D; Ershova A; Sasaki HM; Gowri G; Berengut JF; Corea-Dilbert FE; Yin P; Shih WM, 2022, Multi-micron crisscross structures from combinatorially assembled DNA-origami slats,
    Preprints | 2019
    Berengut JF; Ruan J; Kawamoto A; Lee LK, 2019, Design and Synthesis of Pleated DNA Origami Nanotubes with Adjustable Diameters,
    Conference Papers | 2017
    Baker MA; Tuckwell AJ; Berengut JF; Bath J; Benn F; Duff AP; Whitten AE; Dunn KE; Hynson RM; Turberfield AJ; Lee LK, 2017, 'DNA origami dimensions and structure measured by solution X-ray scattering', in EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, SPRINGER, SCOTLAND, British Biophys Soc, Edinburgh, pp. S137 - S137, presented at 19th IUPAB Congress / 11th EBSA Congress, SCOTLAND, British Biophys Soc, Edinburgh, 16 July 2017 - 20 July 2017,