Dr Kristina Warton

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Dr Kristina Warton completed her PhD at the University of New South Wales, before working for a number of years in biotech and then returning to academia. She is currently leading a project within the Gynaecological Cancer Research Group to develop a blood test for the early diagnosis of ovarian cancer.

Book Chapters | 2022

Mahon K; Samimi G; Warton K, 2022, 'Considerations in Biobanking Blood Samples and Plasma Volume for Circulating DNA Studies', in Cell-Free Circulating DNA, WORLD SCIENTIFIC, pp. 47 - 62,

Book Chapters | 2022

Warton K; Stirzaker C; Samimi G; Clark S, 2022, 'DNA Methylation Analysis of Circulating DNA Biomarkers', in Cell-Free Circulating DNA: Purification and Analysis Techniques, pp. 247 - 277,
Journal articles | 2024

Cortesi M; Liu D; Powell E; Barlow E; Warton K; Ford CE, 2024, 'Accurate Identification of Cancer Cells in Complex Pre-Clinical Models Using a Deep-Learning Neural Network: A Transfection-Free Approach', Advanced Biology, 8,

Journal articles | 2024

Cortesi M; Liu D; Powell E; Barlow E; Warton K; Ford CE, 2024, 'Accurate Identification of Cancer Cells in Complex Pre‐Clinical Models Using a Deep‐Learning Neural Network: A Transfection‐Free Approach (Adv. Biology 11/2024)', Advanced Biology, 8,

Journal articles | 2024

Cortesi M; Warton K; Ford CE, 2024, 'Beyond 2D cell cultures: how 3D models are changing the in vitro study of ovarian cancer and how to make the most of them', PeerJ, 12,

Journal articles | 2024

Fisher T; Powell E; Yuwono NL; Ford CE; Warton K, 2024, 'Circulating cell-free DNA is elevated in postmenopausal compared with pre- and perimenopausal women', Menopause, 31, pp. 171 - 175,

Journal articles | 2024

Werner B; Powell E; Duggan J; Cortesi M; Lee YC; Arora V; Athavale R; Dean M; Warton K; Ford C, 2024, 'Use of cell-free DNA from ascites to identify variants and tumour evolution in a cohort of patients with advanced ovarian cancer.', Journal of Clinical Oncology, 42, pp. 5547 - 5547,

Journal articles | 2024

Werner B; Powell E; Duggan J; Cortesi M; Lee YC; Arora V; Athavale R; Dean M; Warton K; Ford CE, 2024, 'Cell-free DNA from ascites identifies clinically relevant variants and tumour evolution in patients with advanced ovarian cancer', Molecular Oncology, 18, pp. 2668 - 2683,

Journal articles | 2024

Werner B; Sjoquist KM; Espinoza D; Yip S; Chang G; Cummins MM; Mileshkin L; Ananda S; Shannon C; Friedlander M; Warton K; Ford CE, 2024, 'Cell-free DNA in plasma and ascites as a biomarker of bevacizumab response- a translational research sub-study of the REZOLVE (ANZGOG-1101) clinical trial', Translational Oncology, 43,

Journal articles | 2023

Werner B; Sjoquist KM; Espinoza D; Yip S; Chang G; Cummins MM; Mileshkin LR; Ananda S; Shannon CM; Friedlander M; Warton K; Ford C, 2023, 'Cell-free DNA in plasma and ascites as a biomarker of bevacizumab response: A translational sub-study of the REZOLVE (ANZGOG-1101) clinical trial.', Journal of Clinical Oncology, 41, pp. 5561 - 5561,

Journal articles | 2022

Alonso A; Yuwono NL; Houshdaran S; Abbott J; Rodgers R; Ford CE; Warton K, 2022, 'Comparison of total and endometrial circulating cell-free DNA in women with and without endometriosis', Reproductive BioMedicine Online, 44, pp. 495 - 503,

Journal articles | 2022

Fisher T; Ford CE; Warton K, 2022, 'Recovery Efficiency of Cell-Free DNA After Bisulfite Conversion', Clinical Chemistry, 68, pp. 1219 - 1220,

Journal articles | 2022

Hossain KR; Escobar Bermeo JD; Warton K; Valenzuela SM, 2022, 'New Approaches and Biomarker Candidates for the Early Detection of Ovarian Cancer.', Front Bioeng Biotechnol, 10, pp. 819183,

Journal articles | 2022

Werner B; Warton K; Ford CE, 2022, 'Endogenous cell-free DNA in fetal bovine serum introduces artifacts to in vitro cell-free DNA models', BioTechniques, 73, pp. 219 - 226,

Journal articles | 2022

Werner B; Warton K; Ford CE, 2022, 'Transcending Blood—Opportunities for Alternate Liquid Biopsies in Oncology', Cancers, 14,

Journal articles | 2022

Yuwono NL; Alonso A; Abbott J; Houshdaran S; Henry CE; Rodgers R; Ford CE; Warton K, 2022, 'Circulating cell-free endometrial DNA level is unaltered during menstruation and in endometriosis', Human Reproduction, 37, pp. 2560 - 2569,

Journal articles | 2022

Yuwono NL; Boyd MAA; Henry CE; Werner B; Ford CE; Warton K, 2022, 'Circulating cell-free DNA undergoes significant decline in yield after prolonged storage time in both plasma and purified form', Clinical Chemistry and Laboratory Medicine, 60, pp. 1287 - 1298,

Journal articles | 2021

Hagstrom AD; Yuwono N; Warton K; Ford CE, 2021, 'Sex Bias in Cohorts Included in Sports Medicine Research', Sports Medicine, 51, pp. 1799 - 1804,

Journal articles | 2021

Werner B; Yuwono N; Duggan J; Liu D; David C; Srirangan S; Provan P; DeFazio A; Arora V; Farrell R; Lee YC; Warton K; Ford C, 2021, 'Cell-free DNA is abundant in ascites and represents a liquid biopsy of ovarian cancer', Gynecologic Oncology, 162, pp. 720 - 727,

Journal articles | 2021

Yuwono NL; Henry CE; Ford CE; Warton K, 2021, 'Total and endothelial cell-derived cell-free DNA in blood plasma does not change during menstruation', PLoS ONE, 16,

Journal articles | 2021

Yuwono NL; Warton K; Ford CE, 2021, 'The influence of biological and lifestyle factors on circulating cell-free dna in blood plasma', eLife, 10,

Journal articles | 2020

Ford CE; Werner B; Hacker NF; Warton K, 2020, 'The untapped potential of ascites in ovarian cancer research and treatment', British Journal of Cancer, 123, pp. 9 - 16,

Journal articles | 2020

Warton K; Xu Y; Ford CE, 2020, 'Target sequence heterogeneity causes the 'hook effect' in fluorescent dye-based quantitative PCR', BioTechniques, 69, pp. 81 - 84,

Journal articles | 2019

Werner B; Yuwono NL; Henry C; Gunther K; Rapkins RW; Ford CE; Warton K, 2019, 'Circulating cell-free DNA from plasma undergoes less fragmentation during bisulfite treatment than genomic DNA due to low molecular weight', PLoS ONE, 14,

Journal articles | 2018

Warton K; Graham LJ; Yuwono N; Samimi G, 2018, 'Comparison of 4 commercial kits for the extraction of circulating DNA from plasma', Cancer Genetics, 228-229, pp. 143 - 150,

Journal articles | 2017

Warton K; Yuwono NL; Cowley MJ; McCabe MJ; So A; Ford CE, 2017, 'Evaluation of Streck BCT and PAXgene Stabilised Blood Collection Tubes for Cell-Free Circulating DNA Studies in Plasma', Molecular Diagnosis and Therapy, 21, pp. 563 - 570,

Journal articles | 2016

Warton K; Mahon KL; Samimi G, 2016, 'Methylated circulating tumor DNA in blood: Power in cancer prognosis and response', Endocrine-Related Cancer, 23, pp. R157 - R171,

Journal articles | 2015

Warton K; Samimi G, 2015, 'Methylation of cell-free circulating DNA in the diagnosis of cancer', Frontiers in Molecular Biosciences, 2,

Journal articles | 2014

Warton K; Lin V; Navin T; Armstrong NJ; Kaplan W; Ying K; Gloss B; Mangs H; Nair SS; Hacker NF; Sutherland RL; Clark SJ; Samimi G, 2014, 'Methylation-capture and Next-Generation Sequencing of free circulating DNA from human plasma', BMC Genomics, 15,

Journal articles | 2013

Warton K; Vita L; Armstrong NJ; Kaplan W; Ying K; Mangs H; Hacker NF; Sutherland RL; Clark SJ; Samimi G, 2013, 'Whole genome sequencing of free circulating DNA from plasma of HGSOC patients', CLINICAL CANCER RESEARCH, 19,

Journal articles | 2012

Montavon C; Gloss B; Warton K; Barton CA; Statham AL; Scurry J; Tabor B; Nguyen TV; Qu WJ; Samimi G; Hacker NF; Sutherland RL; Clark SJ; O'Brien P, 2012, 'Prognostic and diagnostic significance of DNA methylation patterns in high grade serous ovarian cancer', Gynecologic Oncology, 124, pp. 582 - 588,

Journal articles | 2010

Thompson EW; Warton K; Blick T; Wafai R; Hill P; Stanley K, 2010, 'Multiplexed tandem polymerase chain reaction identifies strong expression of oestrogen receptor and Her-2 from single, formalin-fixed, paraffin-embedded breast cancer sections', Pathology, 42, pp. 165 - 172,

Journal articles | 2007

van Bockel D; Price DA; Asher TE; Venturi V; Suzuki K; Warton K; Davenport MP; Cooper DA; Douek DC; Kelleher AD, 2007, 'Validation of RNA-based molecular clonotype analysis for virus-specific CD8+ T-cells in formaldehyde-fixed specimens isolated from peripheral blood', Journal of Immunological Methods, 326, pp. 127 - 138,

Journal articles | 2006

Gurisik E; Warton K; Martin DK; Valenzuela SM, 2006, 'An in vitro study of the effects of exposure to a GSM signal in two human cell lines: Monocytic U937 and neuroblastoma SK-N-SH', Cell Biology International, 30, pp. 793 - 799,

Journal articles | 2004

Warton K; Foster NC; Gold WA; Stanley K, 2004, 'A novel gene family induced by acute inflammation in endothelial cells', Gene, 342, pp. 85 - 95,

Journal articles | 2002

Warton K; Tonini R; Fairlie WD; Matthews JM; Valenzuela SM; Qiu MR; Wu WM; Pankhurst S; Bauskin AR; Harrop SJ; Campbell TJ; Curmi PM; Breit SN; Mazzanti M, 2002, 'Recombinant CLIC1 (NCC27) assembles in lipid bilayers via a pH-dependent two-state process to form chloride ion channels with identical characteristics to those observed in Chinese Hamster Ovary cells expressing CLIC1', The Journal of Biological Chemistry, 277, pp. 26003 - 26011

Journal articles | 2001

Harrop SJ; Demaere MZ; Fairlie WD; Reztsova T; Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Jankova L; Warton K; Bauskin AR; Wu WM; Pankhurst S; Campbell TJ; Breit SN; Curmi PM, 2001, 'Crystal structure of a soluble form of the Intracellular Chloride Ion Channel CLIC1 (NCC27) at 1.4-A resolution', The Journal of Biological Chemistry, pp. 44993 - 45000

Journal articles | 2000

Tonini R; Ferroni A; Valenzuela SM; Warton K; Campbell TJ; Breit SN; Mazzanti M, 2000, 'Functional characterization of the NCC27 nuclear protein in stable transfected CHO-K1 cells', Federation of American Societies for Experimantal Biology Journal, 14, pp. 1171 - 1178

Journal articles | 2000

Valenzuela SM; Mazzanti M; Tonini R; Qiu MR; Warton K; Musgrove EA; Campbell TJ; Breit SN, 2000, 'The nuclear chloride ion channel NCC27 is involved in regulation of the cell cycle', Journal of Physiology, 529, pp. 541 - 552,

Journal articles | 2000

Warton K; Valenzuela S; Tonini R; Mazzanti M; Breit S, 2000, 'Intracellular Ion Channel NCC27 Moves between a Soluble and a Transmembrane State', Biochemical Society Transactions, 28, pp. A471 - A471,

Journal articles | 1998

Ludowyke RI; Warton K; Scurr LL, 1998, 'Inhibition of antigen and calcium ionophore induced secretion from RBL-2H3 cells by phosphatase inhibitors', Cell Biology International, 22, pp. 855 - 865,

Journal articles | 1997

Valenzuela SM; Martin DJ; Warton K; Por SB; Robbins JM; Bootcov MR; Schofield PR; Campbell TJ; Breit SN, 1997, 'Molecular cloning and expression of a chloride ion channel of cell nuclei.', The Journal of Biological Chemistry, pp. 12575 - 12582
Preprints | 2024

Cortesi M; Li J; Liu D; Guo T; Dokos S; Warton K; Ford C, 2024, A novel approach for the quantification of single-cell adhesion dynamics from microscopy images,

Preprints | 2024

Cortesi M; Liu D; Powell E; Barlow E; Warton K; Giordano E; Ford C, 2024, Development and validation of a computational tool to predict treatment outcomes in cells from High-Grade Serous Ovarian Cancer patients,

Preprints | 2024

Werner B; Powell E; Duggan J; Cortesi M; Lee YC; Arora V; Athavale R; Dean M; Warton K; Ford C, 2024, Cell-free DNA from ascites identifies clinically relevant variants and tumour evolution in patients with advanced ovarian cancer,

Preprints | 2023

Cortesi M; Liu D; Powell E; Barlow E; Warton K; Ford C, 2023, Accurate identification of cancer cells in complex pre-clinical models using deep-learning: a transfection-free approach,

Conference Papers | 2023

Werner B; Powell E; Duggan J; Lee YC; Athavale R; Dean M; Warton K; Ford C, 2023, 'PR004/#458 Cell-free DNA from ascites identifies clinically relevant variants and tumour evolution in a cohort of patients with advanced ovarian cancer', in Featured Posters: Poster Rounds with the Professors, BMJ Publishing Group Ltd, pp. A32.2 - A33, presented at IGCS 2023 Annual Meeting Abstracts,

Conference Papers | 2020

Warton K; Yuwono N; Henry C; Hacker N; Ford C, 2020, 'Abstract B28: Optimizing DNA processing and ovarian cancer methylation-specific PCR assays for the detection of early-stage ovarian cancer', in Clinical Cancer Research, American Association for Cancer Research (AACR), pp. B28 - B28,

Conference Abstracts | 2020

Yuwono NL; Warton K; Henry C; Ford C, 2020, 'Deciphering the origin of circulating cell-free DNA and its alterations during menstruation', in CANCER RESEARCH, AMER ASSOC CANCER RESEARCH, ELECTR NETWORK, Vol. 80, presented at AACR Annual Meeting, ELECTR NETWORK, 22 June 2020 - 24 June 2020,

Conference Papers | 2002

Mazzanti M; Warton K; Tonini R; Lorenzi G; Fairlie D; Matthews JM; Valenzuela S; Qiu MR; Wu WM; Pankhurst S; Bauskin AR; Campbell TJ; Curmi PMG; Breit SN, 2002, 'NCC27 (CLIC1) interacts with artifical bylayer in a pH dependent manner to form chloride ion channels', in BIOPHYSICAL JOURNAL, BIOPHYSICAL SOCIETY, pp. 244A - 244A,

Circulating DNA is DNA that is found in blood plasma and is not associated with any cell population. In patients with cancer, a proportion of this DNA is derived from tumour cells that have died and released their DNA into the bloodstream, so it contains the same mutations and methylation changes as the tumour. We are investigating targeting circulating DNA as a diagnostic test for early ovarian cancer.

• Circulating DNA in early diagnosis of ovarian cancer

• Biobanking

• Mechanisms of circulating DNA generation

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Dr Kristina Warton

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