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Professor Kyle Hoehn

Professor Kyle Hoehn

Professor

1996-2000ÌýBA Chemistry, University of Northern Colorado, Greeley, ColoradoÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌýÌý

1996-2000ÌýBA Biology, University of Northern Colorado, Greeley, ColoradoÌýÌý

2000-2001ÌýMS Biochemistry, Colorado State University, Fort Collins, Colorado

2001-2005ÌýPhD Biochemistry, Colorado State University, Fort Collins, Colorado

Science
School of Biotech & Biomolecular Science

Research Program

The focus of my research laboratory is mitochondrial uncoupler drug development for the treatment of ageing, obesity and related metabolic diseases.

Selected publications (of 99)

  1. 2024 - Zhou M, Li C, Byrne FL, Vancuylenburg CS, Olzomer EM, Hargreaves A, Wu LE, Shackel NA, Santos WL, Hoehn KL. Beneficial effects of MGL-3196 and BAM15 combination in a mouse model of fatty liver disease. Acta Physiologica. 2024 Aug 16:e14217. doi: 10.1111/apha.14217.
  2. 2024 – Beretta M, Dai Y, Olzomer EM, Vancuylenburg CS, Santiago-Rivera JA, Philp AM, Hargett SR, Li K, Shah DP, Chen SY, Alexopoulos SJ, Li C, Harris TE, Lee B, Wathier M, Cermak JM, Tucker SP, Turner N, Bayliss DA, Philp A, Byrne FL, Santos WL and Hoehn KL. Liver-selective imidazolopyrazine mitochondrial uncoupler SHD865 reverses adiposity and glucose intolerance in mice. Diabetes. March 1;73(3):374-384. doi: 10.2337/db23-0233.Ìý
  3. 2024 - Chen SY, Telfser AJ, Olzomer EM, Vancuylenberg CS, Zhou M, Beretta M, Li C, Alexopoulos SJ, Turner N, Byrne FL, Santos WL, Hoehn KL. Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice. Clinical Science. Feb 21;138(4):173-187. doi: 10.1042/CS20231016.
  4. 2023 – Chen SY, Beretta M, Olzomer EM, Shah DP, Wong DYH, Alexopoulos SJ, Aleksovska I, Salamoun JM, Garcia CJ, Cochran BJ, Rye KA, Smith GC, Byrne FL, Morris MJ, Santos WL, Cantley J,ÌýHoehn KL. Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice. Molecular Metabolism. Mar;69:101684. doi: 10.1016/j.molmet.2023.101684.
  5. 2023 – Chen SY, Beretta M, Olzomer EM, Alexopoulos SJ, Shah DP, Byrne FL, Salamoun JM, Garcia CJ, Smith GC, Larance M, Philp A, Turner N, Santos WL, Cantley J, and Hoehn KL. Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice. BBA - Molecular Basis of Disease. doi: 10.1016/j.bbadis.2023.166908
  6. 2023 - Murray JH, Burgio AL, Beretta M, Hargett SR, Harris TE, Olzomer E, Grams RJ, Garcia CJ, Li C, Salamoun JM,ÌýHoehn KL*, Santos WL*. Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity. Journal of Medicinal Chemistry. Mar 23;66(6):3876-3895. doi: 10.1021/acs.jmedchem.2c01573.
  7. 2022 - Yeudall S, Upchurch CM, Seegren PV, Pavelec CM, Greulich J, Lemke MC, Harris TE, Desai BN,ÌýHoehn KL, Leitinger N. Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism. Science Advances. Nov 25;8(47):eabq1984. doi: 10.1126/sciadv.abq1984. Epub 2022 Nov 23.
  8. 2021 - Chen SY, Beretta M, Alexopoulos SJ, Shah DP, Olzomer EM, Hargett SR, Childress ES, Salamoun JM, Aleksovska I, Roseblade A, Cranfield C, Rawling T, Quinlan KGR, Morris MJ, Tucker SP, Santos WL andÌýHoehn KL. Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake. Metabolism. Apr;117:154724. doi: 10.1016/j.metabol.2021.154724.
  9. 2020 – Alexopoulos, A.J.; Chen, S-Y.; Brandon, A.E.; Salamoun, J.; Garcia, C.J.; Beretta, M.; Olzomer, E.; Byrne, F.B.; Shah, D.; Lawrence, R.; Carrive, P.; Tucker, S.P.; Cooney, G.J.; Santos, WL; Hoehn KL. Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice. Nature Communications. May 14;11(1):2397. doi: 10.1038/s41467-020-16298-2.
  10. 2020 – Salamoun J, Garcia C, Hargett S, Murray J, Chen SY, Beretta M, Alexopoulos S, Shah D, Olzomer E, Tucker S, Hoehn KL*, and Santos WL*. 6-Amino-[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Non-alcoholic Steatohepatitis.ÌýJournal of Medicinal Chemistry. Jun 11;63(11):6203-6224. doi: 10.1021/acs.jmedchem.0c00542. *co-corresponding
  11. 2020 – Childress E, Salamoun J, Hargett SH, Alexopoulos SJ, Chen SY, Shah D, Santiago-Rivera J, Garcia C, Dai Y, Tucker SJ, Hoehn KL*, and Santos WL*. [1,2,5]Oxadiazolo[3,4-b]pyrazine-5,6-diamine DerivativesÌý as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis. Journal of Medicinal Chemistry. Feb 4. doi: 10.1021/acs.jmedchem.9b01440 *co-corresponding
  12. 2020 - Byrne FL, Olzomer EM, Marriott GR, Quek LE, Katen A, Su J, Nelson ME, Hart-Smith G, Larance M, Sebesfi VF, Cuff J, Martyn GE, Childress E, Alexopoulos SJ, Poon IK, Faux MC, Burgess AW, Reid G, McCarroll JA, Santos WL, Quinlan KG, Turner N, Fazakerley DJ, Kumar N,Ìýand Hoehn KL. Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress. Redox Biology. Jan;28:101374. doi: 10.1016/j.redox.2019.101374.
  13. 2020 - Knights AJ, Vohralik EJ, Houweling PJ, Stout ES, Norton LJ, Alexopoulos SJ, Yik JJ, Mat Jusoh H, Olzomer EM, Bell-Anderson KS, North KN,ÌýHoehn KL, Crossley M, Quinlan KGR. Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3). Nature Communications. Jun 10;11(1):2922. doi: 10.1038/s41467-020-16758-9
  14. 2018 – Byrne FL, Hargett SR, Lahiri S, Roy RJ, Berr SS, Caldwell SH,ÌýHoehn KL. Serial MRI Imaging Reveals Minimal Impact of Ketogenic Diet on Established Liver Tumor Growth. Cancers. Sep 5;10(9). doi: 10.3390/cancers10090312.
  15. 2017 – Nelson ME, Lahiri S, Chow JDY, Byrne FL, Hargett SR, Breen DS, Olzomer EM, Wu LE, Cooney GJ, Turner N, James DE, Slack-Davis JK, Lackner C, Caldwell SH, andÌýHoehn KL. Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defense and promoting cell survival. Nature Communications. Mar 14;8:14689. doi: 10.1038/ncomms14689.
  16. 2015 – Healy ME, Chow JDY, Byrne FL, Breen DS, Leitinger N, Li C, Lackner C, Caldwell SH, and Hoehn KL. Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine. Journal of Hepatology. Mar;62(3):599-606.
  17. 2015 – Serasinghe MN, Weider SY, Thibaud TR, Elkholi R, Asciolla JJ, Yao JL, Jabado O, Hoehn K, Kageyama Y, Sesake H, and Chipuk JE. Mitochondrial division is requisite to RAS-induced transformation and targeted by mitooncogenic MAPK pathway inhibitors. Molecular Cell. Feb 5;57(3):521-536.
  18. 2015 – Kashatus JA, Nascimento A, Myers L, Sher A, Byrne FL, Hoehn KL, Counter CM, and Kashatus DF. Erk2 phosphorylation of Drp1 promotes mitochondrial fission and Ras-driven tumor growth. Molecular Cell. Feb 5;57(3):537-551.
  19. 2013 – Taddeo EP, Laker RC, Breen DS, Akhtar YN, Kenwood BM, Liao JA, Zhang M, Fazakerley DJ, Tomsig JL, Chow JD, Lynch KR, Chokki M, Molkentin JD, Turner N, James DE, Yan Z, and Hoehn KL. Opening of the Mitochondrial Permeability Transition Pore is Required for Insulin Resistance in Skeletal Muscle. Molecular Metabolism. Nov 26;3(2):124-34.
  20. 2013 – Kenwood BM, Weaver JL, Bajwa A, Poon IK, Byrne FL, Murrow BA, Calderone JA, Huang L, Divakaruni AS, Tomsig JL, Okabe K, Columbus L, Lynch KR, Ravichandran KS, Yan Z, Uchiyama S, Santos WL, Rogers GW, Okusa MD, Bayliss DA, and Hoehn KL. Identification of a Novel Mitochondrial Uncoupler that Does Not Depolarize the Plasma Membrane. Molecular Metabolism. Nov 28;3(2):114-23.
  21. 2011 – Park D, Han C, Elliott MR, Kinchen JM, Trampont PC, Das S, Collins S, Lysiak JJ, Hoehn KL, and Ravichandaran KS. Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein. Nature. Aug 21; 477(7363):220-4.
  22. 2010 - Hoehn KL*, Turner N*, Swarbrick MM, Wilks D, Preston E, Phua Yuwei, Joshi H, Furler SM, Larance M, Hegarty BD, Leslie SJ, Pickford R, Hoy AJ, Kraegen EW, James DE, and Cooney GJ. Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole body energy expenditure or adiposity. Cell Metabolism. Jan; 11(1):70-6. Ìý
  23. 2009 - Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE. Insulin resistance is a cellular antioxidant defense mechanism. PNAS. Oct 20; 106 (42):17787-92.
  24. 2008 - Hoehn KL, Hohnen-Behrens C, Cederberg A, Turner N, Wu L, Yuasa T, Ebina Y, James DE.Ìý IRS-1 Independent Defects Define Major Nodes of Insulin Resistance. Cell Metabolism. May; 7(5):421-33.

Education

  • Bachelor degree inÌýChemistry, Univ. of Northern Colorado 2000
  • Bachelor degree inÌýBiology, Univ. of Northern Colorado 2000
  • Master of Science degree in Biochemistry, Colorado State UniversityÌý2001
  • PhD degree in Biochemistry and Molecular Biology, Colorado State UniversityÌý2005

Research Projects

  • To understand the role of acetyl-CoA carboxylase enzymes in nutrient metabolism
  • ToÌýdevelop new molecules that improve healthy ageing
  • To develop molecules that reverse obesity and related metabolic disorders
  • To determine how dietary nutrients contribute to cancer initiation and/or progression
Phone
+61 (2) 9385 9399
E-mail
k.hoehn@unsw.edu.au
Location
School of Biotechnology and Biomolecular Sciences
  • Book Chapters | 2003
    Hoehn KL; Summers SA, 2003, 'Assaying AKT/Protein Kinase B Activity', in Diabetes Mellitus, Springer Nature, pp. 137 - 144,
  • Journal articles | 2024
    Beretta M; Dai Y; Olzomer EM; Vancuylenburg CS; Santiago-Rivera JA; Philp AM; Hargett SR; Li K; Shah DP; Chen SY; Alexopoulos SJ; Li C; Harris TE; Lee B; Wathier M; Cermak JM; Tucker SP; Turner N; Bayliss DA; Philp A; Byrne FL; Santos WL; Hoehn KL, 2024, 'Liver-Selective Imidazolopyrazine Mitochondrial Uncoupler SHD865 Reverses Adiposity and Glucose Intolerance in Mice', Diabetes, 73, pp. 374 - 384,
    Journal articles | 2024
    Chen SY; Beretta M; Olzomer EM; Alexopoulos SJ; Shah DP; Byrne FL; Salamoun JM; Garcia CJ; Smith GC; Larance M; Philp A; Turner N; Santos WL; Cantley J; Hoehn KL, 2024, 'Head-to-head comparison of BAM15, semaglutide, rosiglitazone, NEN, and calorie restriction on metabolic physiology in female db/db mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870,
    Journal articles | 2024
    Chen SY; Telfser AJ; Olzomer EM; Vancuylenberg CS; Zhou M; Beretta M; Li C; Alexopoulos SJ; Turner N; Byrne FL; Santos WL; Hoehn KL, 2024, 'Beneficial effects of simultaneously targeting calorie intake and calorie efficiency in diet-induced obese mice', Clinical Science, 138, pp. 173 - 187,
    Journal articles | 2024
    Cheng Y; Jones JP; Yu TT; Olzomer EM; Su J; Katen A; Black DSC; Hart-Smith G; Childress ES; Beretta M; Wilkins MR; Mateos IA; Santos WL; Hoehn KL; Byrne FL; Kumar N, 2024, 'Corrigendum to “Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents†[Bioorg. Chem. 151 (2024) 107665] (Bioorganic Chemistry (2024) 151, (S0045206824005704), (10.1016/j.bioorg.2024.107665))', Bioorganic Chemistry, 151,
    Journal articles | 2024
    Cheng Y; Jones JP; Yu TT; Olzomer EM; Su J; Katen A; Black DSC; Hart-Smith G; Childress ES; Wilkins MR; Mateos IA; Santos WL; Hoehn KL; Byrne FL; Kumar N, 2024, 'Design, synthesis and biological evaluation of glucose metabolism inhibitors as anticancer agents', Bioorganic Chemistry, 151,
    Journal articles | 2024
    Foutz MA; Krinos EL; Beretta M; Hargett SR; Shrestha R; Murray JH; Duerre E; Salamoun JM; McCarter K; Shah DP; Hoehn KL; Santos WL, 2024, 'Design, Synthesis, and Biological Evaluation of [1,2,5]Oxadiazolo[3,4-b]pyridin-7-ol as Mitochondrial Uncouplers for the Treatment of Obesity and Metabolic Dysfunction-Associated Steatohepatitis', Journal of Medicinal Chemistry,
    Journal articles | 2024
    Hargett S; Lahiri S; Kowalski GM; Corley S; Nelson ME; Lackner C; Olzomer EM; Aleksovska I; Hearn BA; Shrestha R; Janitz M; Gorrell MD; Bruce CR; Wilkins M; Hoehn KL; Byrne FL, 2024, 'Bile acids mediate fructose-associated liver tumour growth in mice', Biochimica et Biophysica Acta - Molecular Basis of Disease, 1870,
    Journal articles | 2024
    Salamoun JM; Krinos EL; Foutz MA; Hargett SR; Beretta M; Shrestha R; Hoehn KL; Santos WL, 2024, 'Design, synthesis, and biological evaluation of imidazo[4,5-b]pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)', European Journal of Medicinal Chemistry, 280,
    Journal articles | 2024
    Shrestha R; Vancuylenburg CS; Beretta M; Zhou M; Shah DP; Olzomer EM; Richards SL; Hoehn KL; Byrne FL, 2024, 'Complete inhibition of liver acetyl-CoA carboxylase activity is required to exacerbate liver tumorigenesis in mice treated with diethylnitrosamine.', Cancer Metab, 12, pp. 34,
    Journal articles | 2024
    Yau B; Naghiloo S; Diaz-Vegas A; Carr AV; Van Gerwen J; Needham EJ; Jevon D; Chen SY; Hoehn KL; Brandon AE; Macia L; Cooney GJ; Shortreed MR; Smith LM; Keller MP; Thorn P; Larance M; James DE; Humphrey SJ; Kebede MA, 2024, 'Erratum: Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet (iScience (2021) 24(10), (S2589004221010671), (10.1016/j.isci.2021.103099))', iScience, 27,
    Journal articles | 2024
    Zhou M; Li C; Byrne FL; Vancuylenburg CS; Olzomer EM; Hargreaves A; Wu LE; Shackel NA; Santos WL; Hoehn KL, 2024, 'Beneficial effects of MGL-3196 and BAM15 combination in a mouse model of fatty liver disease', Acta Physiologica, 240,
    Journal articles | 2023
    Chen SY; Beretta M; Olzomer EM; Shah DP; Wong DYH; Alexopoulos SJ; Aleksovska I; Salamoun JM; Garcia CJ; Cochran BJ; Rye KA; Smith GC; Byrne FL; Morris MJ; Santos WL; Cantley J; Hoehn KL, 2023, 'Targeting negative energy balance with calorie restriction and mitochondrial uncoupling in db/db mice', Molecular Metabolism, 69,
    Journal articles | 2023
    Murray JH; Burgio AL; Beretta M; Hargett SR; Harris TE; Olzomer E; Grams RJ; Garcia CJ; Li C; Salamoun JM; Hoehn KL; Santos WL, 2023, 'Oxadiazolopyridine Derivatives as Efficacious Mitochondrial Uncouplers in the Prevention of Diet-Induced Obesity', Journal of Medicinal Chemistry, 66, pp. 3876 - 3895,
    Journal articles | 2023
    Takenaka K; Olzomer EM; Hoehn KL; Curry-Hyde A; Jun Chen B; Farrell R; Byrne FL; Janitz M, 2023, 'Investigation of circular RNA transcriptome in obesity-related endometrial cancer', Gene, 855,
    Journal articles | 2022
    Byrne FL; Olzomer EM; Lolies N; Hoehn KL; Wegner MS, 2022, 'Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma', International Journal of Molecular Sciences, 23, pp. 4477,
    Journal articles | 2022
    Chen SY; Olzomer EM; Beretta M; Cantley J; Nunemaker CS; Hoehn KL; Byrne FL, 2022, 'Investigating the Expression and Function of the Glucose Transporter GLUT6 in Obesity', International Journal of Molecular Sciences, 23, pp. 9798,
    Journal articles | 2022
    Dai Y; Santiago-Rivera JA; Hargett S; Salamoun JM; Hoehn KL; Santos WL, 2022, 'Conversion of oxadiazolo[3,4-b]pyrazines to imidazo[4,5-b]pyrazines via a tandem reduction-cyclization sequence generates new mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, 73,
    Journal articles | 2022
    Kaakoush NO; Olzomer EM; Kosasih M; Martin AR; Fargah F; Lambie N; Susic D; Hoehn KL; Farrell R; Byrne FL, 2022, 'Differences in the Active Endometrial Microbiota across Body Weight and Cancer in Humans and Mice', Cancers, 14, pp. 2141,
    Journal articles | 2022
    RODRIGUEZ PARIS V; ALEXOPOULOS SJ; HU Y; SHAH DP; AFLATOUNIAN A; EDWARDS MC; BERTOLDO MJ; GILCHRIST RB; HOEHN KL; WALTERS KA, 2022, 'Mitochondrial Uncoupler BAM15 Ameliorates Associated Metabolic PCOS Traits in a Hyperandrogenic PCOS Mouse Model', Fertility & Reproduction, 04, pp. 208 - 208,
    Journal articles | 2022
    Veprik A; Denwood G; Liu D; Bany Bakar R; Morfin V; McHugh K; Tebeka NN; Vetterli L; Yonova-Doing E; Gribble F; Reimann F; Hoehn KL; Hemsley PA; Ahnfelt-Rønne J; Rorsman P; Zhang Q; de Wet H; Cantley J, 2022, 'Acetyl-CoA-carboxylase 1 (ACC1) plays a critical role in glucagon secretion', Communications Biology, 5,
    Journal articles | 2022
    Yeudall S; Upchurch CM; Seegren PV; Pavelec CM; Greulich J; Lemke MC; Harris TE; Desai BN; Hoehn KL; Leitinger N, 2022, 'Macrophage acetyl-CoA carboxylase regulates acute inflammation through control of glucose and lipid metabolism', Science Advances, 8,
    Journal articles | 2022
    Yeudall S; Upchurch C; Seegren P; Pavelec C; Desai B; Hoehn K; Leitinger N, 2022, 'An Unexpected Role for Acetyl Coenzyme A Carboxylase in Metabolic Control of the Macrophage Acute Inflammatory Response', Free Radical Biology and Medicine, vol. 180, pp. s88 - s88,
    Journal articles | 2021
    Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Hargett SR; Childress ES; Salamoun JM; Aleksovska I; Roseblade A; Cranfield C; Rawling T; Quinlan KGR; Morris MJ; Tucker SP; Santos WL; Hoehn KL, 2021, 'Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake', Metabolism: Clinical and Experimental, 117,
    Journal articles | 2021
    Hoehn KL, 2021, 'How does obesity cause cancer?', Cancers, 13,
    Journal articles | 2021
    Srivastava P; Gunawan C; Soeriyadi A; Amal R; Hoehn K; Marquis C, 2021, 'In vitrocoronal protein signatures and biological impact of silver nanoparticles synthesized with different natural polymers as capping agents', Nanoscale Advances, 3, pp. 4424 - 4439,
    Journal articles | 2021
    Wegner MS; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, 2021, 'Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells', Cellular and Molecular Life Sciences, 78, pp. 7025 - 7041,
    Journal articles | 2021
    Yau B; Naghiloo S; Diaz-Vegas A; Carr AV; Van Gerwen J; Needham EJ; Jevon D; Chen SY; Hoehn KL; Brandon AE; Macia L; Cooney GJ; Shortreed MR; Smith LM; Keller MP; Thorn P; Larance M; James DE; Humphrey SJ; Kebede MA, 2021, 'Proteomic pathways to metabolic disease and type 2 diabetes in the pancreatic islet', iScience, 24,
    Journal articles | 2021
    Zunica ERM; Axelrod CL; Cho E; Spielmann G; Davuluri G; Alexopoulos SJ; Beretta M; Hoehn KL; Dantas WS; Stadler K; King WT; Pergola K; Irving BA; Langohr IM; Yang S; Hoppel CL; Gilmore LA; Kirwan JP, 2021, 'Breast cancer growth and proliferation is suppressed by the mitochondrial targeted furazano[3,4-b]pyrazine BAM15', CANCER & METABOLISM, 9,
    Journal articles | 2020
    Alexopoulos SJ; Chen SY; Brandon AE; Salamoun JM; Byrne FL; Garcia CJ; Beretta M; Olzomer EM; Shah DP; Philp AM; Hargett SR; Lawrence RT; Lee B; Sligar J; Carrive P; Tucker SP; Philp A; Lackner C; Turner N; Cooney GJ; Santos WL; Hoehn KL; Evans A, 2020, 'Mitochondrial uncoupler BAM15 reverses diet-induced obesity and insulin resistance in mice', Nature Communications, 11, pp. 2397,
    Journal articles | 2020
    Axelrod CL; King WT; Davuluri G; Noland RC; Hall J; Hull M; Dantas WS; Zunica ERM; Alexopoulos SJ; Hoehn KL; Langohr I; Stadler K; Doyle H; Schmidt E; Nieuwoudt S; Fitzgerald K; Pergola K; Fujioka H; Mey JT; Fealy C; Mulya A; Beyl R; Hoppel CL; Kirwan JP, 2020, 'BAM15-mediated mitochondrial uncoupling protects against obesity and improves glycemic control', EMBO Molecular Medicine, 12,
    Journal articles | 2020
    Byrne FL; Olzomer EM; Marriott GR; Quek LE; Katen A; Su J; Nelson ME; Hart-Smith G; Larance M; Sebesfi VF; Cuff J; Martyn GE; Childress E; Alexopoulos SJ; Poon IK; Faux MC; Burgess AW; Reid G; McCarroll JA; Santos WL; Quinlan KG; Turner N; Fazakerley DJ; Kumar N; Hoehn KL, 2020, 'Phenotypic screen for oxygen consumption rate identifies an anti-cancer naphthoquinone that induces mitochondrial oxidative stress', Redox Biology, 28, pp. 101374,
    Journal articles | 2020
    Childress ES; Salamoun JM; Hargett SR; Alexopoulos SJ; Chen SY; Shah DP; Santiago-Rivera J; Garcia CJ; Dai Y; Tucker SP; Hoehn KL; Santos WL, 2020, 'Oxadiazolo[3,4- b]pyrazine-5,6-diamine Derivatives as Mitochondrial Uncouplers for the Potential Treatment of Nonalcoholic Steatohepatitis', Journal of Medicinal Chemistry, 63, pp. 2511 - 2526,
    Journal articles | 2020
    Flynn MC; Kraakman MJ; Tikellis C; Lee MKS; Hanssen NMJ; Kammoun HL; Pickering RJ; Dragoljevic D; Al-Sharea A; Barrett TJ; Hortle F; Byrne FL; Olzomer E; McCarthy DA; Schalkwijk CG; Forbes JM; Hoehn K; Makowski L; Lancaster GI; El-Osta A; Fisher EA; Goldberg IJ; Cooper ME; Nagareddy PR; Thomas MC; Murphy AJ, 2020, 'Transient Intermittent Hyperglycemia Accelerates Atherosclerosis by Promoting Myelopoiesis', Circulation Research, 127, pp. 877 - 892,
    Journal articles | 2020
    Knights AJ; Vohralik EJ; Houweling PJ; Stout ES; Norton LJ; Alexopoulos SJ; Yik JJ; Mat Jusoh H; Olzomer EM; Bell-Anderson KS; North KN; Hoehn KL; Crossley M; Quinlan KGR, 2020, 'Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3)', Nature Communications, 11,
    Journal articles | 2020
    Murray JH; Hargett S; Hoehn KL; Santos WL, 2020, 'Anilinopyrazines as potential mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, 30,
    Journal articles | 2020
    Märklin M; Tandler C; Kopp HG; Hoehn KL; Quintanilla-Martinez L; Borst O; Müller MR; Saur SJ, 2020, 'C-Cbl regulates c-MPL receptor trafficking and its internalization', Journal of Cellular and Molecular Medicine, 24, pp. 12491 - 12503,
    Journal articles | 2020
    Salamoun JM; Garcia CJ; Hargett SR; Murray JH; Chen SY; Beretta M; Alexopoulos SJ; Shah DP; Olzomer EM; Tucker SP; Hoehn KL; Santos WL, 2020, '6-Amino[1,2,5]oxadiazolo[3,4- b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis', Journal of Medicinal Chemistry, 63, pp. 6203 - 6224,
    Journal articles | 2020
    Schömel N; Gruber L; Alexopoulos SJ; Trautmann S; Olzomer EM; Byrne FL; Hoehn KL; Gurke R; Thomas D; Ferreirós N; Geisslinger G; Wegner MS, 2020, 'UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells', Scientific Reports, 10, pp. 8182,
    Journal articles | 2019
    Cantley J; Davenport A; Vetterli L; Nemes NJ; Whitworth PT; Boslem E; Thai LM; Mellett N; Meikle PJ; Hoehn KL; James DE; Biden TJ, 2019, 'Disruption of beta cell acetyl-CoA carboxylase-1 in mice impairs insulin secretion and beta cell mass', Diabetologia, 62, pp. 99 - 111,
    Journal articles | 2019
    Caruana BT; Byrne FL; Knights AJ; Quinlan KGR; Hoehn KL, 2019, 'Characterization of glucose transporter 6 in lipopolysaccharide-induced bone marrow-derived macrophage function', Journal of Immunology, 202, pp. 1826 - 1832,
    Journal articles | 2019
    Gemta LF; Siska PJ; Nelson ME; Gao X; Liu X; Locasale JW; Yagita H; Slingluff CL; Hoehn KL; Rathmell JC; Bullock TNJ, 2019, 'Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells', Science Immunology, 4,
    Journal articles | 2019
    Huo Y; Buckton LK; Bennett JL; Smith EC; Byrne FL; Hoehn KL; Rahimi MN; McAlpine SR, 2019, 'Delivering bioactive cyclic peptides that target Hsp90 as prodrugs', Journal of Enzyme Inhibition and Medicinal Chemistry, 34, pp. 728 - 739,
    Journal articles | 2019
    Jiménez de Oya N; Esler WP; Huard K; El-Kattan AF; Karamanlidis G; Blázquez AB; Ramos-Ibeas P; Escribano-Romero E; Louloudes-Lázaro A; Casas J; Sobrino F; Hoehn K; James DE; Gutiérrez-Adán A; Saiz JC; Martín-Acebes MA, 2019, 'Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models', Emerging Microbes and Infections, 8, pp. 624 - 636,
    Journal articles | 2019
    Podwika S; Gabel A; Slack-Davis J; Shupnik M; Hoehn K; Modesitt SC, 2019, 'Physical Activity, Nutrition and Hormone Levels of Postmenopausal Women With and Without Endometrial Cancer [40R]', Obstetrics & Gynecology, 133, pp. 202S - 202S,
    Journal articles | 2019
    Schömel N; Hancock SE; Gruber L; Olzomer EM; Byrne FL; Shah D; Hoehn KL; Turner N; Grösch S; Geisslinger G; Wegner MS, 2019, 'UGCG influences glutamine metabolism of breast cancer cells', Scientific Reports, 9, pp. 15665,
    Journal articles | 2019
    Xu Y; Mak HY; Lukmantara I; Li YE; Hoehn KL; Huang X; Du X; Yang H, 2019, 'CDP-DAG synthase 1 and 2 regulate lipid droplet growth through distinct mechanisms', Journal of Biological Chemistry, 294, pp. 16740 - 16755,
    Journal articles | 2018
    Burchfield JG; Kebede MA; Meoli CC; Stöckli J; Whitworth PT; Wright AL; Hoffman NJ; Minard AY; Ma X; Krycer JR; Nelson ME; Tan SX; Yau B; Thomas KC; Wee NKY; Khor EC; Enriquez RF; Vissel B; Biden TJ; Baldock PA; Hoehn KL; Cantley J; Cooney GJ; James DE; Fazakerley DJ; Wright A, 2018, 'High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice', Journal of Biological Chemistry, 293, pp. 5731 - 5745,
    Journal articles | 2018
    Byrne FL; Hargett SR; Lahiri S; Roy RJ; Berr SS; Caldwell SH; Hoehn KL, 2018, 'Serial MRI imaging reveals minimal impact of ketogenic diet on established liver tumor growth', Cancers, 10, pp. 312,
    Journal articles | 2018
    Byrne FL; Olzomer EM; Brink R; Hoehn KL, 2018, 'Knockout of glucose transporter GLUT6 has minimal effects on whole body metabolic physiology in mice', American Journal of Physiology - Endocrinology and Metabolism, 315, pp. E286 - E293,
    Journal articles | 2018
    Chaudhuri R; Krycer JR; Fazakerley DJ; Fisher-Wellman KH; Su Z; Hoehn KL; Yang JYH; Kuncic Z; Vafaee F; James DE, 2018, 'The transcriptional response to oxidative stress is part of, but not sufficient for, insulin resistance in adipocytes', Scientific Reports, 8, pp. 1774,
    Journal articles | 2018
    Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2018, 'Analysis of the circular RNA transcriptome in endometrial cancer', Oncotarget, 9, pp. 5786 - 5796,
    Journal articles | 2018
    Childress ES; Alexopoulos SJ; Hoehn KL; Santos WL, 2018, 'Small Molecule Mitochondrial Uncouplers and Their Therapeutic Potential', Journal of Medicinal Chemistry, 61, pp. 4641 - 4655,
    Journal articles | 2018
    Fazakerley DJ; Chaudhuri R; Yang P; Maghzal GJ; Thomas KC; Krycer JR; Humphrey SJ; Parker BL; Fisher-Wellman KH; Meoli CC; Hoffman NJ; Diskin C; Burchfield JG; Cowley MJ; Kaplan W; Modrusan Z; Kolumam G; Yang JYH; Chen DL; Samocha-Bonet D; Greenfield JR; Hoehn KL; Stocker R; James DE; Chen D; Southwell Keely P, 2018, 'Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance', eLife, 7, pp. e32111,
    Journal articles | 2018
    Knights AJ; Vohralik EJ; Hoehn KL; Crossley M; Quinlan KGR, 2018, 'Defining Eosinophil Function in Adiposity and Weight Loss', BioEssays, 40,
    Journal articles | 2018
    Meher AK; Serbulea V; Upchurch CM; Osinski V; Sahu S; Hargett S; Hoehn KL; Harris TE; Klibanov AL; McNamara CA; Leitinger N, 2018, 'Abstract 428: An Unexpected Role for ACC in Lipid Droplet Formation in Macrophages in Response to Acellular Adipocyte Fat', Arteriosclerosis, Thrombosis, and Vascular Biology, 38,
    Journal articles | 2018
    Serasinghe MN; Gelles JD; Li K; Zhao L; Abbate F; Syku M; Mohammed JN; Badal B; Rangel CA; Hoehn KL; Celebi JT; Chipuk JE, 2018, 'Dual suppression of inner and outer mitochondrial membrane functions augments apoptotic responses to oncogenic MAPK inhibition', Cell Death and Disease, 9, pp. 29,
    Journal articles | 2018
    Turner N; Lim XY; Toop HD; Osborne B; Brandon AE; Taylor EN; Fiveash CE; Govindaraju H; Teo JD; McEwen HP; Couttas TA; Butler SM; Das A; Kowalski GM; Bruce CR; Hoehn KL; Fath T; Schmitz-Peiffer C; Cooney GJ; Montgomery MK; Morris JC; Don AS; Brandon A, 2018, 'A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism', Nature Communications, 9, pp. 3165,
    Journal articles | 2017
    Caruana BT; Hoehn KL, 2017, 'The race to find endometrial cancer biomarkers', Surgery for Obesity and Related Diseases, 13, pp. 869 - 870,
    Journal articles | 2017
    Chen BJ; Byrne FL; Takenaka K; Modesitt SC; Olzomer EM; Mills JD; Farrell R; Hoehn KL; Janitz M, 2017, 'Transcriptome landscape of long intergenic non-coding RNAs in endometrial cancer', Gynecologic Oncology, 147, pp. 654 - 662,
    Journal articles | 2017
    Gordon HM; Majithia N; MacDonald PE; Fox JEM; Sharma PR; Byrne FL; Hoehn KL; Evans-Molina C; Langman L; Brayman KL; Nunemaker CS, 2017, 'STEAP4 expression in human islets is associated with differences in body mass index, sex, HbA1c, and inflammation', Endocrine, 56, pp. 528 - 537,
    Journal articles | 2017
    Krycer JR; Yugi K; Hirayama A; Fazakerley DJ; Quek LE; Scalzo R; Ohno S; Hodson MP; Ikeda S; Shoji F; Suzuki K; Domanova W; Parker BL; Nelson ME; Humphrey SJ; Turner N; Hoehn KL; Cooney GJ; Soga T; Kuroda S; James DE, 2017, 'Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism', Cell Reports, 21, pp. 3536 - 3547,
    Journal articles | 2017
    Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, 8, pp. 14689,
    Journal articles | 2017
    Taddeo EP; Hargett SR; Lahiri S; Nelson ME; Liao JA; Li C; Slack-Davis JK; Tomsig JL; Lynch KR; Yan Z; Harris TE; Hoehn KL, 2017, 'Lysophosphatidic acid counteracts glucagon-induced hepatocyte glucose production via STAT3', Scientific Reports, 7, pp. 127,
    Journal articles | 2016
    Baker W; Paquette C; Byrne FL; Atkins KA; Shupnik M; Modesitt SC; Hoehn KL; Slack-Davis JK, 2016, 'Postmenopausal endometrial cancer patients have significantly higher expression of GLUT6 in the endometrium', Gynecologic Oncology, 141, pp. 175 - 176,
    Journal articles | 2016
    Biwer L; Taddeo E; Hoehn K; Straub A; Isakson B, 2016, 'Lipid composition of the myoendothelial junction allows for compartmentalized eNOS function', The FASEB Journal, 30,
    Journal articles | 2016
    Biwer LA; Taddeo EP; Kenwood BM; Hoehn KL; Straub AC; Isakson BE, 2016, 'Two functionally distinct pools of eNOS in endothelium are facilitated by myoendothelial junction lipid composition', Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids, 1861, pp. 671 - 679,
    Journal articles | 2016
    Brandon AE; Stuart E; Leslie SJ; Hoehn KL; James DE; Kraegen EW; Turner N; Cooney GJ, 2016, 'Minimal impact of age and housing temperature on the metabolic phenotype of Acc2-/- mice', Journal of Endocrinology, 228, pp. 127 - 134,
    Journal articles | 2016
    Byrne FL; Hoehn KL, 2016, 'Subclassification of fatty liver by its pathogenesis: CIEFing is believing', Journal of Pathology, 239, pp. 3 - 5,
    Journal articles | 2016
    Healy ME; Lahiri S; Hargett SR; Chow JDY; Byrne FL; Breen DS; Kenwood BM; Taddeo EP; Lackner C; Caldwell SH; Hoehn KL, 2016, 'Dietary sugar intake increases liver tumor incidence in female mice', Scientific Reports, 6, pp. 22292,
    Journal articles | 2016
    Laker RC; Taddeo EP; Akhtar YN; Zhang M; Hoehn KL; Yan Z, 2016, 'The mitochondrial permeability transition pore regulator cyclophilin D exhibits tissue-specific control of metabolic homeostasis', PLoS ONE, 11,
    Journal articles | 2016
    Narayanan S; Nieh AH; Kenwood BM; Davis CA; Tosello-Trampont AC; Elich TD; Breazeale SD; Ward E; Anderson RJ; Caldwell SH; Hoehn KL; Hahn YS, 2016, 'Distinct roles for intracellular and extracellular lipids in hepatitis C virus infection', PLoS ONE, 11,
    Journal articles | 2016
    Takenaka K; Chen BJ; Modesitt SC; Byrne FL; Hoehn KL; Janitz M, 2016, 'The emerging role of long non-coding RNAs in endometrial cancer', Cancer Genetics, 209, pp. 445 - 455,
    Journal articles | 2015
    Bajwa A; Rosin DL; Chroscicki P; Lee S; Dondeti K; Ye H; Kinsey GR; Stevens BK; Jobin K; Kenwood BM; Hoehn KL; Lynch KR; Okusa MD, 2015, 'Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury', Journal of the American Society of Nephrology, 26, pp. 908 - 925,
    Journal articles | 2015
    Chaudhuri R; Khoo PS; Tonks K; Junutula JR; Kolumam G; Modrusan Z; Samocha-Bonet D; Meoli CC; Hocking S; Fazakerley DJ; Stöckli J; Hoehn KL; Greenfield JR; Yang JYH; James DE; Milliken S; Goodnow C, 2015, 'Cross-species gene expression analysis identifies a novel set of genes implicated in human insulin sensitivity', npj Systems Biology and Applications, 1, pp. 15010,
    Journal articles | 2015
    Cronk SM; Kelly-Goss MR; Ray HC; Mendel TA; Hoehn KL; Bruce AC; Dey BK; Guendel AM; Tavakol DN; Herman IM; Peirce SM; Yates PA, 2015, 'Adipose-derived stem cells from diabetic mice show impaired vascular stabilization in a murine model of diabetic retinopathy', Stem Cells Translational Medicine, 4, pp. 459 - 467,
    Journal articles | 2015
    Du X; Zhang Y; Jo SR; Liu X; Qi Y; Osborne B; Byrne FL; Smith GC; Turner N; Hoehn KL; Brown AJ; Yang H, 2015, 'Akt activation increases cellular cholesterol by promoting the proteasomal degradation of Niemann-Pick C1', Biochemical Journal, 471, pp. 243 - 253,
    Journal articles | 2015
    Hargett SR; Walker NN; Hussain SS; Hoehn KL; Keller SR, 2015, 'Deletion of the rab GAP Tbc1d1 modifies glucose, lipid, and energy homeostasis in mice', American Journal of Physiology - Endocrinology and Metabolism, 309, pp. E233 - E245,
    Journal articles | 2015
    Healy ME; Chow JDY; Byrne FL; Breen DS; Leitinger N; Li C; Lackner C; Caldwell SH; Hoehn KL, 2015, 'Dietary effects on liver tumor burden in mice treated with the hepatocellular carcinogen diethylnitrosamine', Journal of Hepatology, 62, pp. 599 - 606,
    Journal articles | 2015
    Kashatus JA; Nascimento A; Myers LJ; Sher A; Byrne FL; Hoehn KL; Counter CM; Kashatus DF, 2015, 'Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth', Molecular Cell, 57, pp. 537 - 551,
    Journal articles | 2015
    Kenwood BM; Calderone JA; Taddeo EP; Hoehn KL; Santos WL, 2015, 'Structure-activity relationships of furazano[3,4-b]pyrazines as mitochondrial uncouplers', Bioorganic and Medicinal Chemistry Letters, 25, pp. 4858 - 4861,
    Journal articles | 2015
    Laker R; Taddeo E; Zhang M; Hoehn K; Yan Z, 2015, 'The Mitochondrial Permeability Transition Pore Regulator Cyclophilin D Exhibits Tissueâ€Specific Control of Metabolic 91³ÉÈ˰涶Òôostasis', The FASEB Journal, 29,
    Journal articles | 2015
    Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2015, 'Acetyl CoA carboxylase 2 is dispensable for CD8+ T cell responses', PLoS ONE, 10, pp. e0137776,
    Journal articles | 2015
    Modesitt SC; Hallowell PT; Hoehn KL; Slack-Davis JK; Kelley SL; Arapovic S; Shupnik M, 2015, 'Changes in metabolic profiles before and after bariatric surgery in high risk morbidly obese women: Obesity-related carcinogenesis is not all about hormones', Gynecologic Oncology, 137, pp. 26 - 26,
    Journal articles | 2015
    Modesitt SC; Hallowell PT; Slack-Davis JK; Michalek RD; Atkins KA; Kelley SL; Arapovic S; Shupnik MA; Hoehn K, 2015, 'Women at extreme risk for obesity-related carcinogenesis: Baseline endometrial pathology and impact of bariatric surgery on weight, metabolic profiles and quality of life', Gynecologic Oncology, 138, pp. 238 - 245,
    Journal articles | 2015
    Saur SJ; Märklin M; Ganser M; Hoehn K; David JE; Borst O; Kanz L; Kopp H-G; Mueller MR, 2015, 'C-Cbl Regulates c-Mpl Receptor Trafficking and Its Internalization', Blood, 126, pp. 2388 - 2388,
    Journal articles | 2015
    Serasinghe MN; Wieder SY; Renault TT; Elkholi R; Asciolla JJ; Yao JL; Jabado O; Hoehn K; Kageyama Y; Sesaki H; Chipuk JE, 2015, 'Mitochondrial division is requisite to RAS-induced transformation and targeted by oncogenic MAPK pathway inhibitors', Molecular Cell, 57, pp. 521 - 536,
    Journal articles | 2014
    Bupp MG; Litvin S; Edwards R; Mihalcoe B; Byrne F; Hoehn K; Anoff J, 2014, 'The forkhead transcription factor, Foxo1, may coordinate naive CD8+T cell homeostasis with energy availability in mice.', JOURNAL OF IMMUNOLOGY, 192,
    Journal articles | 2014
    Byrne FL; Poon IKH; Modesitt SC; Tomsig JL; Chow JDY; Healy ME; Baker WD; Atkins KA; Lancaster JM; Marchion DC; Moley KH; Ravichandran KS; Slack-Davis JK; Hoehn KL, 2014, 'Metabolic vulnerabilities in endometrial cancer', Cancer Research, 74, pp. 5832 - 5845,
    Journal articles | 2014
    Chow JDY; Lawrence RT; Healy ME; Dominy JE; Liao JA; Breen DS; Byrne FL; Kenwood BM; Lackner C; Okutsu S; Mas VR; Caldwell SH; Tomsig JL; Cooney GJ; Puigserver PB; Turner N; James DE; Villén J; Hoehn KL, 2014, 'Genetic inhibition of hepatic acetyl-CoA carboxylase activity increases liver fat and alters global protein acetylation', Molecular Metabolism, 3, pp. 419 - 431,
    Journal articles | 2014
    Kenwood BM; Weaver JL; Bajwa A; Poon IK; Byrne FL; Murrow BA; Calderone JA; Huang L; Divakaruni AS; Tomsig JL; Okabe K; Lo RH; Cameron Coleman G; Columbus L; Yan Z; Saucerman JJ; Smith JS; Holmes JW; Lynch KR; Ravichandran KS; Uchiyama S; Santos WL; Rogers GW; Okusa MD; Bayliss DA; Hoehn KL, 2014, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism, 3, pp. 114 - 123,
    Journal articles | 2014
    Laker RC; Lillard TS; Okutsu M; Zhang M; Hoehn KL; Connelly JJ; Yan Z, 2014, 'Exercise prevents maternal high-fat diet-induced hypermethylation of the Pgc-1α gene and age-dependent metabolic dysfunction in the offspring', Diabetes, 63, pp. 1605 - 1611,
    Journal articles | 2014
    Laker RC; Xu P; Ryall KA; Sujkowski A; Kenwood BM; Chain KH; Zhang M; Royal MA; Hoehn KL; Driscoll M; Adler PN; Wessells RJ; Saucerman JJ; Yan Z, 2014, 'A novel mitotimer reporter gene for mitochondrial content, structure, stress, and damage in vivo', Journal of Biological Chemistry, 289, pp. 12005 - 12015,
    Journal articles | 2014
    Lee JE; Walsh MC; Hoehn KL; James DE; Wherry EJ; Choi Y, 2014, 'Regulator of fatty acid metabolism, acetyl coenzyme a carboxylase 1, controls T cell immunity', Journal of Immunology, 192, pp. 3190 - 3199,
    Journal articles | 2014
    Narayanan S; Hoehn K; Kenwood B; Nieh A; Tosello-Trampont A; Davis C; Caldwell S; Hahn Y, 2014, 'Altered lipid metabolism influences course of hepatitis C virus infection and hepatocyte cytokine production', JOURNAL OF IMMUNOLOGY, 192,
    Journal articles | 2014
    Taddeo EP; Laker RC; Breen DS; Akhtar YN; Kenwood BM; Liao JA; Zhang M; Fazakerley DJ; Tomsig JL; Harris TE; Keller SR; Chow JD; Lynch KR; Chokki M; Molkentin JD; Turner N; James DE; Yan Z; Hoehn KL, 2014, 'Opening of the mitochondrial permeability transition pore links mitochondrial dysfunction to insulin resistance in skeletal muscle', Molecular Metabolism, 3, pp. 124 - 134,
    Journal articles | 2013
    Caldwell S; Hoehn KL; Hahn YS, 2013, 'The strange and critical intersection of hepatitis C and lipoprotein metabolism: "C-zing" the oil', Hepatology, 57, pp. 1684 - 1687,
    Journal articles | 2013
    Cantley J; Whitworth PT; Davenport A; Hoehn KL; James DE; Biden TJ, 2013, 'Acetyl-CoA carboxylase-1 is a critical regulator of beta cell size and proliferation', DIABETIC MEDICINE, 30, pp. 8 - 9,
    Journal articles | 2013
    Kenwood BM; Weaver JL; Byrne FL; Murrow BA; Tomsig JL; Cameron Coleman G; Yan Z; Lynch KR; Bayliss DA; Hoehn KL; Bajwa A; Huang L; Okusa MD; Poon IK; Ravichandran KS; Divakaruni AS; Saucerman JJ; Smith JS; Holmes JW; Rogers GW; Lo RH; Columbus L; Okabe K; Uchiyama S; Calderone JA; Santos WL, 2013, 'Identification of a novel mitochondrial uncoupler that does not depolarize the plasma membrane', Molecular Metabolism,
    Journal articles | 2013
    Lira VA; Okutsu M; Zhang M; Greene NP; Laker RC; Breen DS; Hoehn KL; Yan Z, 2013, 'Autophagy is required for exercise training-induced skeletal muscle adaptation and improvement of physical performance', FASEB Journal, 27, pp. 4184 - 4193,
    Journal articles | 2012
    Cleasby ME; Hoehn KL; Patel SA; Lawrence RT; Sawbridge L; Talbot NA; Turner N; Cooney GJ; Whitehead JP; Kraegen EW, 2012, 'Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity', DIABETOLOGIA, 55, pp. S244 - S245,
    Journal articles | 2012
    Hoehn KL; Turner N; Cooney GJ; James DE, 2012, 'Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice (Journal of Biological Chemistry (2012) 287, (15801))', Journal of Biological Chemistry, 287, pp. 20468,
    Journal articles | 2012
    Hoehn KL; Turner N; Cooney GJ; James DE, 2012, 'Phenotypic discrepancies in acetyl-CoA carboxylase 2-deficient mice', The Journal of Biological Chemistry, 287, pp. 15801,
    Journal articles | 2012
    Modesitt SC; Hsu JY; Chowbina SR; Lawrence RT; Hoehn KL, 2012, 'Not all fat is equal: Differential gene expression and potential therapeutic targets in subcutaneous adipose, visceral adipose, and endometrium of obese women with and without endometrial cancer', International Journal of Gynecological Cancer, 22, pp. 732 - 741,
    Journal articles | 2012
    Patel SA; Hoehn KL; Lawrence RT; Sawbridge L; Talbot NA; Tomsig JL; Turner N; Cooney GJ; Whitehead JP; Kraegen E; Cleasby ME, 2012, 'Overexpression of the adiponectin receptor AdipoR1 in rat skeletal muscle amplifies local insulin sensitivity', Endocrinology, 153, pp. 5231 - 5246,
    Journal articles | 2011
    Park D; Han CZ; Elliott MR; Kinchen JM; Trampont PC; Das S; Collins S; Lysiak JJ; Hoehn KL; Ravichandran KS, 2011, 'Continued clearance of apoptotic cells critically depends on the phagocyte Ucp2 protein', Nature, 477, pp. 220 - 224,
    Journal articles | 2010
    Akhtar YN; Lira VA; Zhang M; Okutsu M; Hoehn KL; Yan Z, 2010, 'Genetic ablation of cyclophilin D, a component of the mitochondrial permeability transition pore, improves insulin sensitivity in high-fat fed mice', FASEB JOURNAL, 24,
    Journal articles | 2010
    Hoehn KL; Holland WL; Knotts TA; Summers SA, 2010, 'The etiology of obesity-induced insulin resistance', Insulin Resistance: Symptoms, Causes and Treatment, pp. 205 - 238
    Journal articles | 2010
    Hoehn KL; Turner N; Swarbrick MM; Wilks D; Preston E; Phua Y; Joshi H; Furler SM; Larance M; Hegarty BD; Leslie SJ; Pickford R; Hoy AJ; Kraegen EW; James DE; Cooney GJ; Hegarty , 2010, 'Acute or chronic upregulation of mitochondrial fatty acid oxidation has no net effect on whole-body energy expenditure or adiposity', Cell Metabolism, 11, pp. 70 - 76,
    Journal articles | 2010
    Larance M; Rowland AF; Hoehn KL; Humphreys D; Preiss T; Guilhaus M; James DE, 2010, 'Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3', Molecular and Cellular Proteomics, 9, pp. 682 - 694,
    Journal articles | 2010
    Murrow BA; Hoehn KL, 2010, 'Mitochondrial regulation of insulin action', International Journal of Biochemistry and Cell Biology, 42, pp. 1936 - 1939,
    Journal articles | 2010
    Richards AA; Colgrave ML; Zhang J; Webster J; Simpson F; Preston E; Wilks D; Hoehn KL; Stephenson M; Macdonald GAM; Prins J; Cooney GJ; Xu A; Whitehead JR, 2010, 'Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation', Molecular Endocrinology, 24, pp. 229 - 239,
    Journal articles | 2009
    Crowe SM; Wu LE; Economou C; Turpin S; Matzaris M; Hoehn KL; Hevener A; James DE; Duh E; Watt M, 2009, 'Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity', Cell Metabolism, 10, pp. 40 - 47
    Journal articles | 2009
    Hoehn K; Salmon A; Hohnen-Behrens C; Turner N; Hoy A; Maghzal G; Stocker R; Van remmen H; Kraegen E; Cooney GJ; Richardson A; James DE, 2009, 'Insulin resistance is a cellular antioxidant defense mechanism', Proceedings of the National Academy of Sciences of the United States of America, 106, pp. 17787 - 17792,
    Journal articles | 2009
    Hoehn KL; Holland WL; Knotts TA; Summers SA, 2009, 'The etiology of obesity-induced insulin resistance', Diabetes Mellitus Research Advances, pp. 99 - 132
    Journal articles | 2008
    Hoehn K; Hohnen-Behrens C; Cederberg A; Wu LE; Turner N; Yuasa T; Ebina Y; James DE, 2008, 'IRS1-independent defects define major nodes of insulin resistance', Cell Metabolism, 7, pp. 421 - 433,
    Journal articles | 2008
    Yip M; Ramm G; Larance MC; Hoehn K; Wagner M; Guilhaus M; James DE, 2008, 'CaMKII-Mediated Phosphorylation of the Myosin Motor Myolc Is Required for Insulin-Stimulated GLUT4 Translocation in Adipocytes', Cell Metabolism, 8, pp. 384 - 398
    Journal articles | 2007
    Holland WL; Brozinick JT; Wang LP; Hawkins ED; Sargent KM; Liu Y; Narra K; Hoehn KL; Knotts TA; Siesky A; Nelson DH; Karathanasis SK; Fontenot GK; Birnbaum MJ; Summers SA, 2007, 'Inhibition of Ceramide Synthesis Ameliorates Glucocorticoid-, Saturated-Fat-, and Obesity-Induced Insulin Resistance', Cell Metabolism, 5, pp. 167 - 179,
    Journal articles | 2007
    Holland WL; Knotts TA; Chavez JA; Wang L-P; Hoehn KL; Summers SA, 2007, 'Lipid mediators of insulin resistance', NUTRITION REVIEWS, 65, pp. S39 - S46,
    Journal articles | 2007
    Holland WL; Knotts TA; Chavez JA; Wang LP; Hoehn KL; Summers SA, 2007, 'Lipid Mediators of Insulin Resistance', Nutrition Reviews, 65,
    Journal articles | 2007
    Holland WL; Knotts TA; Chavez JA; Wang LP; Hoehn KL; Summers SA, 2007, 'Lipid mediators of insulin resistance.', Nutrition reviews, 65
    Journal articles | 2007
    Turner N; Bruce CR; Beale S; Hoehn K; So T; Rolph MS; Cooney GJ, 2007, 'Excess lipid availability increases mitochondrial fatty acid oxidative capacity in muscle - Evidence against a role for reduced fatty acid oxidation in lipid-induced insulin resistance in rodents', Diabetes, 56, pp. 2085 - 2092
    Journal articles | 2006
    Cress KE; Hoehn KL; Florant GL, 2006, 'The hunger switch', The FASEB Journal, 20,
    Journal articles | 2004
    Hoehn KL; Hudachek SF; Summers SA; Florant GL, 2004, 'Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators', AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 286, pp. R498 - R504,
    Journal articles | 2004
    Hoehn KL; Hudachek SF; Summers SA; Florant GL, 2004, 'Seasonal, tissue-specific regulation of Akt/protein kinase B and glycogen synthase in hibernators', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 286,
    Journal articles | 2004
    Stratford S; Hoehn KL; Liu F; Summers SA, 2004, 'Regulation of insulin action by ceramide: Dual mechanisms linking ceramide accumulation to the inhibition of Akt/protein kinase B', Journal of Biological Chemistry, 279, pp. 36608 - 36615,
    Journal articles | 2003
    Hoehn KL; Summers SA, 2003, 'Assaying AKT/protein kinase B activity.', Methods in molecular medicine, 83, pp. 137 - 144,
  • Preprints | 2022
    Byrne F; Olzomer E; Lolies N; Hoehn KL; Wegner M-S, 2022, Update on Glycosphingolipids Abundance in Hepatocellular Carcinoma,
    Conference Abstracts | 2022
    Perera C; Hossain MJ; Mekapogu AR; Hosen SMZ; Rajan P; Xu Z; Greenfield J; Hoehn K; Horadagoda N; Chari S; Pirola R; Wilson J; Apte MV, 2022, 'PANCREATIC CANCER-RELATED DIABETES: A HIGH FRUCTOSE DIET FED TO TRANSGENIC, KRAS(LSL-G12D/+); PDXCRE/+ (KC) MICE, IS ASSOCIATED WITH PANCREATIC STELLATE CELL ACTIVATION AND ACCELERATED CANCER PROGRESSION', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, CA, San Diego, Vol. 162, pp. S562 - S563, presented at Digestive Disease Week (DDW), CA, San Diego, 21 May 2022 - 24 May 2022,
    Conference Abstracts | 2022
    Yeudall S; Upchurch C; Seegren P; Pavelec C; Desai B; Hoehn K; Leitinger N, 2022, 'An Unexpected Role for Acetyl Coenzyme A Carboxylase in Metabolic Control of the Macrophage Acute Inflammatory Response', in Free Radical Biology and Medicine, Elsevier BV, Vol. 180, pp. s88 - s88,
    Preprints | 2021
    Wegner M-S; Schömel N; Olzomer EM; Trautmann S; Olesch C; Byrne FL; Brüne B; Gurke R; Ferreirós N; Weigert A; Geisslinger G; Hoehn KL, 2021, Increased glucosylceramide production leads to decreased cell energy metabolism and lowered tumor marker expression in non-cancerous liver cells,
    Conference Papers | 2014
    Saur SJ; Maerklin M; Poljak A; Ganser M; James DE; Hoehn K; Kanz L; Kopp H-G; Mueller MR, 2014, 'C-CBL Is a Critical Negative Regulator of Megakaryopoesis', in BLOOD, AMER SOC HEMATOLOGY, CA, San Francisco, presented at 56th Annual Meeting of the American-Society-of-Hematology, CA, San Francisco, 06 December 2014 - 09 December 2014,
    Conference Abstracts | 2013
    Cantley J; Whitworth PT; Davenport A; Hoehn KL; James DE; Biden TJ, 2013, 'Acetyl-CoA carboxylase 1 is a critical regulator of beta cell mass', in DIABETOLOGIA, SPRINGER, Barcelona, SPAIN, Vol. 56, pp. S74 - S74, presented at 49th Annual Meeting of the European-Association-for-the-Study-of-Diabetes (EASD), Barcelona, SPAIN, 23 September 2013 - 27 September 2013,

Our research is supported by 2 NHMRC Ideas grants (2022-2025), 1 NHMRC Development grant (2022-2024), and 1 NIH-R01 grant (2021-2025).