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Dr Laurence Luu

Dr Laurence Luu

Adjunct Associate Lecturer
Science
School of Biotech & Biomolecular Science

Laurence Luu is an adjunct associate lecturer in and research group. He is currently researching how the interactions between host immunogenetics and the microbiome leads to cancers of the gastrointestinal tract and inflammatory bowel disease.

Laurence previously completed his PhD in the under the supervision of and Dr. Sophie Octavia where he investigated the evolution of Bordetella pertussis to vaccines. During his PhD, he discovered new proteomic adaptations that were associated with increased fitness in the current Australian epidemic B. pertussis population. This discovery garnered widespread media attention and led to a national call to improve vaccines for whooping cough.

Laurence continued his research on whooping cough in the Evolutionary Microbiology lab as a postdoctoral researcher where he applied proteomics and functional genomics to better understand the biology and molecular pathogenesis of B. pertussis infections in order to improveÌýcurrent vaccines and develop new treatments. He currently remains an honorary member of the lab.

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Professional Experience

2019 - Current: , Australian Society for Microbiology (ASM)

2018 - Current: Postdoctoral Research Associate, School of Biotechnology and Biomolecular Sciences, UNSW

2018 - PhD in Medical Microbiology and Immunology,ÌýUNSW

2014 - Bachelor of Medical Science (Hons I), UNSW

Ìý

Awards

2019 -

2019 - ASM NSW-ACT Branch Postdoctoral Award

2018 -

2017 -

2017 - ASM NSW-ACT Branch Student Prize
Phone
+61-2-9385 3063
E-mail
laurence.luu@unsw.edu.au
Location
L4, Biological Sciences North D26
  • Journal articles | 2024
    Luu LDW; Pandey A; Paramsothy S; Ngo C; Castaño-Rodríguez N; Liu C; Kamm MA; Borody TJ; Man SM; Kaakoush NO, 2024, 'Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice', Nature Communications, 15,
    Journal articles | 2024
    Luu LDW; Rafique R; Payne M; Octavia S; Robson J; Sintchenko V; Lan R, 2024, 'Deciphering Bordetella pertussis epidemiology through culture-independent multiplex amplicon and metagenomic sequencing.', J Clin Microbiol, 62, pp. e0117824,
    Journal articles | 2024
    Majzoub ME; Luu LDW; Haifer C; Paramsothy S; Borody TJ; Leong RW; Thomas T; Kaakoush NO, 2024, 'Refining microbial community metabolic models derived from metagenomics using reference-based taxonomic profiling', mSystems, 9,
    Journal articles | 2024
    Strange N; Luu L; Ong V; Wee BA; Phillips MJA; McCaughey L; Steele JR; Barlow CK; Cranfield CG; Myers G; Mazraani R; Rock C; Timms P; Huston WM, 2024, 'HtrA, fatty acids, and membrane protein interplay in Chlamydia trachomatis to impact stress response and trigger early cellular exit', Journal of Bacteriology, 206,
    Journal articles | 2024
    Wang Y; Yang S; Han B; Du X; Sun H; Du Y; Liu Y; Lu P; Di J; Luu LDW; Lv X; Hu S; Wang L; Jiang R, 2024, 'Single-cell landscape revealed immune characteristics associated with disease phases in brucellosis patients', iMeta, 3,
    Journal articles | 2023
    Haifer C; Luu LDW; Paramsothy S; Borody TJ; Leong RW; Kaakoush NO, 2023, 'Microbial determinants of effective donors in faecal microbiota transplantation for UC', Gut, 72, pp. 90 - 100,
    Journal articles | 2023
    Huang X; Li F; Wang Y; Jia X; Jia N; Xiao F; Sun C; Fu J; Chen M; Cui X; Qu D; Wai Luu LD; Tai J; Li J, 2023, 'Multi-omics analysis reveals underlying host responses in pediatric respiratory syncytial virus pneumonia', iScience, 26,
    Journal articles | 2023
    Jury B; Fleming C; Huston WM; Luu LDW, 2023, 'Corrigendum: Molecular pathogenesis of Chlamydia trachomatis (Frontiers in Cellular and Infection Microbiology, (2023), 13, (1281823), 10.3389/fcimb.2023.1281823)', Frontiers in Cellular and Infection Microbiology, 13,
    Journal articles | 2023
    Jury B; Fleming C; Huston WM; Luu LDW, 2023, 'Molecular pathogenesis of Chlamydia trachomatis', Frontiers in Cellular and Infection Microbiology, 13,
    Journal articles | 2023
    Luu LDW; Kasimov V; Phillips S; Myers GSA; Jelocnik M, 2023, 'Genome organization and genomics in Chlamydia: whole genome sequencing increases understanding ofÌýchlamydial virulence, evolution, and phylogeny', Frontiers in Cellular and Infection Microbiology, 13,
    Journal articles | 2023
    Suyama H; Luu LDW; Zhong L; Raftery MJ; Lan R, 2023, 'Integrating proteomic data with metabolic modeling provides insight into key pathways of Bordetella pertussis biofilms', Frontiers in Microbiology, 14,
    Journal articles | 2023
    Wang Y; Huang X; Li F; Jia X; Jia N; Fu J; Liu S; Zhang J; Ge H; Huang S; Hui Y; Sun C; Xiao F; Cui X; Luu LDW; Qu D; Li J; Tai J, 2023, 'Serum-integrated omics reveal the host response landscape for severe pediatric community-acquired pneumonia', Critical Care, 27,
    Journal articles | 2023
    Wang Y; Luu LDW; Liu S; Zhu X; Huang S; Li F; Huang X; Guo L; Zhang J; Ge H; Sun Y; Hui Y; Qu Y; Wang H; Wang X; Na W; Zhou J; Qu D; Tai J, 2023, 'Single-cell transcriptomic analysis reveals a systemic immune dysregulation in COVID-19-associated pediatric encephalopathy', Signal Transduction and Targeted Therapy, 8,
    Journal articles | 2023
    Wang Y; Sun Q; Zhang Y; Li X; Liang Q; Guo R; Zhang L; Han X; Wang J; Shao L; Xue Y; Yang Y; Li H; Nie L; Shi W; Liu Q; Zhang J; Duan H; Huang H; Luu LDW; Tai J; Yang X; Wang G, 2023, 'Systemic immune dysregulation in severe tuberculosis patients revealed by a single-cell transcriptome atlas', Journal of Infection, 86, pp. 421 - 438,
    Journal articles | 2023
    Wang Y; Wang X; Jia X; Li J; Fu J; Huang X; Cui X; Wang B; Luo W; Lin C; Li Z; Luu LDW; Li S; Zhu X; Tai J, 2023, 'Influenza vaccination features revealed by a single-cell transcriptome atlas', Journal of Medical Virology, 95,
    Journal articles | 2023
    Yang X; Yan J; Xue Y; Sun Q; Zhang Y; Guo R; Wang C; Li X; Liang Q; Wu H; Wang C; Liao X; Long S; Zheng M; Wei R; Zhang H; Liu Y; Che N; Luu LDW; Pan J; Wang G; Wang Y, 2023, 'Single-cell profiling reveals distinct immune response landscapes in tuberculous pleural effusion and non-TPE', Frontiers in Immunology, 14,
    Journal articles | 2022
    Don Wai Luu L; Kaakoush NO; Castaño-Rodríguez N, 2022, 'The role of ATG16L2 in autophagy and disease', Autophagy, 18, pp. 2537 - 2546,
    Journal articles | 2022
    Haifer C; Paramsothy S; Kaakoush NO; Saikal A; Ghaly S; Yang T; Luu LDW; Borody TJ; Leong RW, 2022, 'Lyophilised oral faecal microbiota transplantation for ulcerative colitis (LOTUS): a randomised, double-blind, placebo-controlled trial', The Lancet Gastroenterology and Hepatology, 7, pp. 141 - 151,
    Journal articles | 2022
    Huang X; Luu LDW; Jia N; Zhu J; Fu J; Xiao F; Liu C; Li S; Shu G; Hou J; Kang M; Zhang D; Xu Y; Wang Y; Cui X; Lai J; Li J; Tai J, 2022, 'Multi-Platform Omics Analysis Reveals Molecular Signatures for Pathogenesis and Activity of Systemic Lupus Erythematosus', Frontiers in Immunology, 13,
    Journal articles | 2022
    Li J; Luu LDW; Wang X; Cui XD; Huang X; Fu J; Zhu X; Li Z; Wang Y; Tai J, 2022, 'Metabolomic analysis reveals potential biomarkers and the underlying pathogenesis involved in Mycoplasma pneumoniae pneumonia', Emerging Microbes and Infections, 11, pp. 593 - 605,
    Journal articles | 2022
    Lu LDW; Singh H; Castaño-Rodríguez N; Leach ST; Riordan SM; Tedla N; Krishnan U; Kaakoush NO, 2022, 'Changes to the upper gastrointestinal microbiotas of children with reflux oesophagitis and oesophageal metaplasia', Microbial Genomics, 8,
    Journal articles | 2022
    Luu LDW; Lan R, 2022, 'Rapid Surface Shaving for Proteomic Identification of Novel Surface Antigens for Vaccine Development', , 2414, pp. 47 - 62,
    Journal articles | 2022
    Wang Y; Wang X; Luu LDW; Chen S; Jin F; Wang S; Huang X; Wang L; Zhou X; Chen X; Cui X; Li J; Tai J; Zhu X, 2022, 'Proteomic and Metabolomic Signatures Associated With the Immune Response in Healthy Individuals Immunized With an Inactivated SARS-CoV-2 Vaccine', Frontiers in Immunology, 13,
    Journal articles | 2022
    Wang Y; Wang X; Luu LDW; Li J; Cui X; Yao H; Chen S; Fu J; Wang L; Wang C; Yuan R; Cai Q; Huang X; Huang J; Li Z; Li S; Zhu X; Tai J, 2022, 'Single-cell transcriptomic atlas reveals distinct immunological responses between COVID-19 vaccine and natural SARS-CoV-2 infection', Journal of Medical Virology, 94, pp. 5304 - 5324,
    Journal articles | 2022
    Xu Z; Hu D; Luu LDW; Octavia S; Keil AD; Sintchenko V; Tanaka MM; Mooi FR; Robson J; Lan R, 2022, 'Genomic dissection of the microevolution of Australian epidemic Bordetella pertussis', Emerging Microbes and Infections, 11, pp. 1460 - 1473,
    Journal articles | 2021
    Li S; Huang J; Ren L; Jiang W; Wang M; Zhuang L; Zheng Q; Yang R; Zeng Y; Luu LDW; Wang Y; Tai J, 2021, 'A one-step, one-pot CRISPR nucleic acid detection platform (CRISPR-top): Application for the diagnosis of COVID-19', Talanta, 233,
    Journal articles | 2021
    Luu LDW; Payne M; Zhang X; Luo L; Lan R, 2021, 'Development and comparison of novel multiple cross displacement amplification (MCDA) assays with other nucleic acid amplification methods for SARS-CoV-2 detection', Scientific Reports, 11, pp. 1873,
    Journal articles | 2021
    Luu LDW; Zhong L; Kaur S; Raftery MJ; Lan R, 2021, 'Comparative Phosphoproteomics of Classical Bordetellae Elucidates the Potential Role of Serine, Threonine and Tyrosine Phosphorylation in Bordetella Biology and Virulence', Frontiers in Cellular and Infection Microbiology, 11,
    Journal articles | 2021
    Payne M; Octavia S; Luu LDW; Sotomayor-Castillo C; Wang Q; Tay ACY; Sintchenko V; Tanaka MM; Lan R, 2021, 'Enhancing genomics-based outbreak detection of endemic salmonella enterica serovar typhimurium using dynamic thresholds', Microbial Genomics, 7, pp. 000310,
    Journal articles | 2021
    Wang Y; Wang X; Wai Luu LD; Chen S; Jin F; Wang S; Huang X; Wang L; Zhou X; Chen X; Cui X; Li J; Tai J; Zhu X, 2021, 'Proteomic and metabolomic signatures associated with the immune response in healthy individuals immunized with an inactivated SARS-CoV-2 vaccine', ,
    Journal articles | 2020
    James LJ; Saglimbene V; Wong G; Tong A; Luu LDW; Craig J; Howard K; Howell M, 2020, 'Behavioural and pharmaceutical interventions for the prevention of skin cancers in solid organ transplant recipients: A systematic review of randomised controlled trials', BMJ Open, 10,
    Journal articles | 2020
    Kaur S; Peters T; Yang P; Luu LDW; Vuong J; Krycer J; O’Donoghue S, 2020, 'Temporal ordering of omics and multiomic events inferred from time series data', ,
    Journal articles | 2020
    Kaur S; Peters TJ; Yang P; Luu LDW; Vuong J; Krycer JR; O’Donoghue SI, 2020, 'Temporal ordering of omics and multiomic events inferred from time-series data', npj Systems Biology and Applications, 6,
    Journal articles | 2020
    Liu F; Chen S; Luu LDW; Lee SA; Tay ACY; Wu R; Riordan SM; Lan R; Liu L; Zhang L, 2020, 'Analysis of complete Campylobacter concisus genomes identifies genomospecies features, secretion systems and novel plasmids and their association with severe ulcerative colitis', Microbial Genomics,
    Journal articles | 2020
    Luu LDW; Octavia S; Aitken C; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2020, 'Surfaceome analysis of Australian epidemic Bordetella pertussis reveals potential vaccine antigens', Vaccine, 38, pp. 539 - 548,
    Journal articles | 2020
    Wai Luu LD; Payne M; Zhang X; Luo L; Lan R, 2020, 'Development and comparison of a novel multiple cross displacement amplification (MCDA) assay with other nucleic acid amplification methods for SARS-CoV-2 detection', ,
    Journal articles | 2019
    Kamachi K; Otsuka N; Fumimoto R; Ozawa K; Yao SM; Chiang CS; Luu LDW; Lan R; Shibayama K; Watanabe M, 2019, 'A novel multilocus variable-number tandem repeat analysis for Bordetella parapertussis', Journal of Medical Microbiology, 68, pp. 1671 - 1676,
    Journal articles | 2019
    Luu LDW, 2019, 'Pathogen adaptation to vaccination: The Australian Bordetella pertussis story', Microbiology Australia, 40, pp. 177 - 180,
    Journal articles | 2019
    Xu Z; Octavia S; Luu LDW; Payne M; Timms V; Tay CY; Keil AD; Sintchenko V; Guiso N; Lan R, 2019, 'Pertactin-negative and filamentous hemagglutinin-negative Bordetella pertussis, Australia, 2013-2017', Emerging Infectious Diseases, 25, pp. 1196 - 1199,
    Journal articles | 2018
    Luu LDW; Octavia S; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2018, 'Proteomic Adaptation of Australian Epidemic Bordetella pertussis', Proteomics, 18,
    Journal articles | 2018
    Wai Luu LD; Octavia S; Zhong L; Raftery MJ; Sintchenko V; Lan R, 2018, 'Comparison of the whole cell proteome and secretome of epidemic bordetella pertussis strains from the 2008–2012 Australian epidemic under sulfate-modulating conditions', Frontiers in Microbiology, 9,
    Journal articles | 2017
    Luu LDW; Octavia S; Zhong L; Raftery M; Sintchenko V; Lan R, 2017, 'Characterisation of the Bordetella pertussis secretome under different media', Journal of Proteomics, 158, pp. 43 - 51,
    Journal articles | 2016
    Safarchi A; Octavia S; Luu LDW; Tay CY; Sintchenko V; Wood N; Marshall H; McIntyre P; Lan R, 2016, 'Better colonisation of newly emerged Bordetella pertussis in the co-infection mouse model study', Vaccine, 34, pp. 3967 - 3971,
    Journal articles | 2015
    Safarchi A; Octavia S; Luu LDW; Tay CY; Sintchenko V; Wood N; Marshall H; McIntyre P; Lan R, 2015, 'Pertactin negative Bordetella pertussis demonstrates higher fitness under vaccine selection pressure in a mixed infection model', Vaccine, 33, pp. 6277 - 6281,
  • Preprints | 2024
    Suyama H; Luu LDW; Zhong L; Raftery MJ; Lan R, 2024, Proteomic comparison of epidemic AustralianBordetella pertussisbiofilm cells,
    Conference Abstracts | 2022
    Luu LD; Singh H; Castano-Rodriguez N; Leach ST; Stephen R; Tedla N; Krishnan U; Kaakoush NO, 2022, 'ENRICHMENT OF PREVOTELLA IS A CONSISTENT SIGNATURE IN THE METAPLASTIC ESOPHAGUS IN CHILDREN AND ADULTS', in GASTROENTEROLOGY, W B SAUNDERS CO-ELSEVIER INC, Vol. 162, pp. S833 - S833,
    Conference Abstracts | 2022
    Luu LD; Singh H; Castaño-Rodríguez N; Leach ST; Stephen R; Tedla N; Krishnan U; Kaakoush NO, 2022, 'Mo1603: ENRICHMENT OF PREVOTELLA IS A CONSISTENT SIGNATURE IN THE METAPLASTIC ESOPHAGUS IN CHILDREN AND ADULTS', in Gastroenterology, Elsevier BV, Vol. 162, pp. S - 833,
    Conference Papers | 2022
    Luu LDW; Popple G; Tsang SPW; Vinasco K; Hilmi I; Ng RT; Chew KS; Wong SY; Riordan S; Lee WS; Mitchell HM; Kaakoush NO; Castaño-Rodríguez N, 2022, 'Genetic variants involved in innate immunity modulate the risk of inflammatory bowel diseases in an understudied Malaysian population', in Journal of Gastroenterology and Hepatology (Australia), pp. 342 - 351,
    Preprints | 2022
    Suyama H; Luu LDW; Zhong L; Raftery MJ; Lan R, 2022, Integrating proteomic data with metabolic modelling provides insight into key pathways ofBordetella pertussisbiofilms,
    Preprints | 2022
    Xu Z; Hu D; Wai Luu LD; Octavia S; Keil A; Sintchenko V; Tanaka M; Mooi F; Robson J; Lan R, 2022, Genomic dissection of the microevolution of Australian epidemic Bordetella pertussis,
    Preprints | 2021
    Wang Y; Wang X; Luu LDW; Li J; Cui X; Yao H; Zhang X; Chen S; Fu J; Wang L; Wang C; Yuan R; Cai Q; Huang X; Huang J; Xu W; Li S; Zhu X; Tai J, 2021, Single-cell transcriptomic atlas of individuals receiving inactivated COVID-19 vaccines reveals distinct immunological responses between vaccine and natural SARS-CoV-2 infection,
    Preprints |
    Wang Y; Li F; Huang X; Jia X; Jia N; Xiao F; Sun C; Fu J; Chen M; Cui X; Qu D; Luu LDW; Tai J; Li J, Integrated Proteomic and Metabolomic Analysis Reveals Underlying Host Responses in Pediatric Respiratory Syncytial Virus Pneumonia,
    Preprints |
    Wang Y; Luu LDW; Sun Q; Zhang Y; Li X; Liang Q; Guo R; Zhang L; Han X; Wang J; Shao L; Xue Y; Yang Y; Li H; Nie L; Shi W; Liu Q; Zhang J; Duan H; Huang H; Tai J; Yang X; Wang G, Tuberculosis Immune Landscapes Revealed by a Single-Cell Transcriptome Atlas: An Omics Study,