Dr Lindsay Wu

Senior Res Fellow (NH&MRC)

BSc (Hons I) (Sydney), PhD (UNSW)

Medicine & Health

School of Biomedical Sciences

The Laboratory for Ageing Research is works on that could maintain healthy ageing. These have immediate applications in other conditions, including , preventing the long-term adverse effects of chemotherapy treatment, and understanding why older people are so much more susceptible to coronavirus infection.��

The following projects and more are available for study at both the honours and PhD level...

New treatments to maintain female fertility during biological ageing and following chemotherapy treatment
Role of the pentose phosphate pathway and the enzyme glucose-6-phosphate dehydrogenase in reproductive ageing
DNA transposons in genome instability and the regulation of lifespan
New treatments to reduce the side effects of chemotherapy and improve long-term health in cancer survivors
Studies of the metabolism of nicotinamide adenine dinucleotide (NAD⁺)
Age-related changes in innate immunity and metabolism during coronavirus infection

Our lab uses��molecular biology, animal physiology, metabolomics and bioinformatics to address our questions. We have maintained consistent NHMRC funding since 2015 and are always interested in passionate new lab members.

Phone

+61 2 9385 1621

E-mail

lindsay.wu@unsw.edu.au

Book Chapters | 2020

Li C; Chalmers TJ; Wong ASA; Zhou M; Marinova MB; Bertoldo MJ; Wu LE, 2020, 'Chapter Six Hepatic regeneration in aging: Cell type plasticity and redundancies', in The Stem Cell Niche during Ageing, Elsevier, pp. 127 - 171,

Book Chapters | 2020

Wu L, 2020, 'Hepatic regeneration in aging: Cell type plasticity and redundancies', in Nilsson S (ed.), The Stem Cell Niche during Ageing, Academic Press, pp. 127 - 171,

Book Chapters | 2016

Massudi H; Wu LE; Sinclair DA, 2016, 'Sirtuin Activation by Small Molecules', in Houtkooper RH (ed.), SIRTUINS, SPRINGER, pp. 243 - 266,
Journal articles | 2024

Campbell JM; Habibalahi A; Agha A; Handley S; Knab A; Xu X; Bhargava A; Lei Z; Mackevicius M; Tian Y; Mahbub SB; Anwer AG; Gronthos S; Paton S; Grey ST; Wu L; Gilchrist RB; Goldys EM, 2024, 'Single cell, Label free Characterisation of Human Mesenchymal Stromal cell Stemness and Future Growth Potential by Autofluorescence Multispectral Imaging', Stem Cell Reviews and Reports, 20, pp. 2283 - 2292,

Journal articles | 2024

Campbell JM; Mahbub SB; Anwer AG; Habibalahi A; Gronthos S; Paton S; Grey ST; Wu LE; Gilchrist RB; Goldys EM, 2024, 'Multispectral Imaging of Collagen, NAD(P)H and Flavin Autofluorescence in Mesenchymal Stem Cells Undergoing Trilineage Differentiation', Cells, 13,

Journal articles | 2024

Ho WHJ; Marinova MB; Listijono DR; Bertoldo MJ; Richani D; Kim LJ; Brown A; Riepsamen AH; Cabot S; Frost ER; Bustamante S; Zhong L; Selesniemi K; Wong D; Madawala R; Marchante M; Goss DM; Li C; Araki T; Livingston DJ; Turner N; Sinclair DA; Walters KA; 91��˰涶��r HA; Gilchrist RB; Wu LE, 2024, 'Fertility protection during chemotherapy treatment by boosting the NAD(P)⁺ metabolome', EMBO Molecular Medicine, 16, pp. 2583 - 2618,

Journal articles | 2024

Mihalas BP; Marston AL; Wu LE; Gilchrist RB, 2024, 'Reproductive Ageing: Metabolic contribution to age-related chromosome missegregation in mammalian oocytes', Reproduction (Cambridge, England), 168,

Journal articles | 2024

Zhou M; Li C; Byrne FL; Vancuylenburg CS; Olzomer EM; Hargreaves A; Wu LE; Shackel NA; Santos WL; Hoehn KL, 2024, 'Beneficial effects of MGL-3196 and BAM15 combination in a mouse model of fatty liver disease', Acta Physiologica, 240,

Journal articles | 2023

Gilchrist R; Ho W-HJ; Marinova MB; Listijono DR; Bertoldo MJ; Richani D; Lynn-Jee K; Brown A; Riepsamen AH; Cabot S; Bustamante S; Zhong L; Selesniemi K; Wong D; Goss DM; Li C; Araki T; Livingston DJ; Turner N; Sinclair DA; Walters KA; 91��˰涶��r HA; Wu LE, 2023, '#389 : Fertility Preservation During Chemotherapy Treatment by NAD+ Repletion in Mice', Fertility & Reproduction, 05, pp. 518 - 518,

Journal articles | 2023

Kim LJ; Chalmers TJ; Madawala R; Smith GC; Li C; Das A; Poon EWK; Wang J; Tucker SP; Sinclair DA; Quek LE; Wu LE, 2023, 'Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation', FEBS Letters, 597, pp. 2196 - 2220,

Journal articles | 2023

Navas LE; Blanco-Alcaina E; Suarez-Martinez E; Verdugo-Sivianes EM; Espinosa-Sanchez A; Sanchez-Diaz L; Dominguez-Medina E; Fernandez-Rozadilla C; Carracedo A; Wu LE; Carnero A, 2023, 'NAD pool as an antitumor target against cancer stem cells in head and neck cancer', Journal of Experimental and Clinical Cancer Research, 42,

Journal articles | 2023

Wu LE; Fiveash CE; Bentley NL; Kang MJ; Govindaraju H; Barbour JA; Wilkins BP; Hancock SE; Madawala R; Das A; Massudi H; Li C; Kim LJ; Wong ASA; Marinova MB; Sultani G; Das A; Youngson NA; Le��Couteur DG; Sinclair DA; Turner N, 2023, 'SIRT2 transgenic over-expression does not impact lifespan in mice', Aging Cell, 22,

Journal articles | 2022

Aflatounian A; Paris VR; Richani D; Edwards MC; Cochran BJ; Ledger WL; Gilchrist RB; Bertoldo MJ; Wu LE; Walters KA, 2022, 'Declining muscle NAD⁺ in a hyperandrogenism PCOS mouse model: Possible role in metabolic dysregulation', Molecular Metabolism, 65,

Journal articles | 2022

Campbell JM; Mahbub SB; Bertoldo MJ; Habibalahi A; Goss DM; Ledger WL; Gilchrist RB; Wu LE; Goldys EM, 2022, 'Multispectral autofluorescence characteristics of reproductive aging in old and young mouse oocytes', Biogerontology, 23, pp. 237 - 249,

Journal articles | 2022

HABIBALAHI A; BERTOLDO MJ; MAHBUB SB; CAMPBELL JM; GOSS DM; LEDGER WL; GILCHRIST RB; WU LE; GOLDYS EM, 2022, 'Assessment of Oocyte Quality Using Deep Radiomic Signature of Oocyte Morphology in the Mouse', Fertility & Reproduction, 04, pp. 135 - 135,

Journal articles | 2022

Habibalahi A; Campbell JM; Bertoldo MJ; Mahbub SB; Goss DM; Ledger WL; Gilchrist RB; Wu LE; Goldys EM, 2022, 'Unique Deep Radiomic Signature Shows NMN Treatment Reverses Morphology of Oocytes from Aged Mice', Biomedicines, 10,

Journal articles | 2022

MARINOVA MB; HO W-HJ; BERTOLDO MJ; LOVRIC V; SELESNIEMI K; WALSH WR; SINCLAIR DA; WALTERS K; GILCHRIST RB; WU LE, 2022, 'NMN Supplementation Rescues Fertility and Bone Strength in Chemotherapy-Treated Mice', Fertility & Reproduction, 04, pp. 149 - 149,

Journal articles | 2021

Bertoldo MJ; Paris VR; Gook DA; Edwards MC; Wu K; Liang CJJ; Marinova MB; Wu LE; Walters KA; Gilchrist RB; Rodriguez Paris V, 2021, 'Impact of nicotinamide mononucleotide on transplanted mouse ovarian tissue', Reproduction, 161, pp. 215 - 226,

Journal articles | 2021

Capraro A; Wong S; Adhikari A; Allan K; Patel H; Zhong L; Raftery M; Jaffe A; Yeang M; Aggarwal A; Wu L; Pandzic E; Whan R; Turville S; Vittorio O; Bull R; Kaakoush N; Rawlinson W; Tedla N; Vafaee F; Waters S, 2021, 'Ageing impairs the airway epithelium defence response to SARS-CoV-2', ,

Journal articles | 2021

Li C; Wu LE, 2021, 'Risks and rewards of targeting NAD⁺ homeostasis in the brain', Mechanisms of Ageing and Development, 198,

Journal articles | 2021

Yu J; Laybutt DR; Kim LJ; Quek LE; Wu LE; Morris MJ; Youngson NA, 2021, 'Exercise-induced benefits on glucose handling in a model of diet-induced obesity are reduced by concurrent nicotinamide mononucleotide', American Journal of Physiology - Endocrinology and Metabolism, 321, pp. E176 - E189,

Journal articles | 2020

Bertoldo MJ; Listijono DR; Ho WHJ; Riepsamen AH; Goss DM; Richani D; Jin XL; Mahbub S; Campbell JM; Habibalahi A; Loh WGN; Youngson NA; Maniam J; Wong ASA; Selesniemi K; Bustamante S; Li C; Zhao Y; Marinova MB; Kim LJ; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O'Neill C; Gilchrist RB; Sinclair DA; 91��˰涶��r HA; Wu LE, 2020, 'NAD⁺ Repletion Rescues Female Fertility during Reproductive Aging', Cell Reports, 30, pp. 1670 - 1681.e7,

Journal articles | 2020

Bertoldo MJ; Smitz J; Wu LE; Lee HC; Woodruff TK; Gilchrist RB, 2020, 'Prospects of Rescuing Young Eggs for Oncofertility', Trends in Endocrinology and Metabolism, 31, pp. 708 - 711,

Journal articles | 2020

Chalmers TJ; Wu LE, 2020, 'Transposable Elements Cross Kingdom Boundaries and Contribute to Inflammation and Ageing: Somatic Acquisition of Foreign Transposable Elements as a Catalyst of Genome Instability, Epigenetic Dysregulation, Inflammation, Senescence, and Ageing', BioEssays, 42, pp. e1900197,

Journal articles | 2020

Kim L-J; Chalmers T; Madawala R; Smith G; Li C; Das A; Keung Poon EW; Wang J; Tucker S; Sinclair D; Quek L-E; Wu L, 2020, 'Nicotinamide mononucleotide (NMN) deamidation by host-microbiome interactions', ,

Journal articles | 2020

Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2020, 'Erratum: The Ratio of Macronutrients, Not Caloric Intake, Dictates Cardiometabolic Health, Aging, and Longevity in Ad Libitum-Fed Mice (Cell Metabolism (2014) 19(3) (418–430), (S1550413114000655), (10.1016/j.cmet.2014.02.009))', Cell Metabolism, 31, pp. 654,

Journal articles | 2020

Yu J; Laybutt DR; Kim L-J; Quek L-E; Wu LE; Morris MJ; Youngson NA, 2020, 'EXERCISE-INDUCED BENEFITS ON GLUCOSE HANDLING IN A MODEL OF DIET-INDUCED OBESITY ARE REDUCED BY CONCURRENT NICOTINAMIDE MONONUCLEOTIDE', , pp. 2020.06.22.164459,

Journal articles | 2019

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2019, 'Erratum: Impairment of an Endothelial NAD⁺-H2S Signaling Network Is a Reversible Cause of Vascular Aging (Cell (2018) 173(1) (74–89.e20), (S0092867418301521) (10.1016/j.cell.2018.02.008))', Cell, 176, pp. 944 - 945,

Journal articles | 2019

Wu LE; Sinclair DA, 2019, 'The elusive NMN transporter is found', Nature Metabolism, 1, pp. 8 - 9,

Journal articles | 2018

Bonkowski MS; Das A; Schultz M; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair D, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, 2, pp. 388 - 388

Journal articles | 2018

Bonkowski MS; Das A; Schultz MB; Lu Y; Mitchell J; Wu L; Guarente L; Sinclair DA, 2018, 'IMPAIRMENT OF AN ENDOTHELIAL NAD+-H2S SIGNALING NETWORK IS A REVERSIBLE CAUSE OF VASCULAR AGING', Innovation in aging, 2, pp. 799 - 799

Journal articles | 2018

Bustamante S; Jayasena T; Richani D; Gilchrist RB; Wu LE; Sinclair DA; Sachdev PS; Braidy N, 2018, 'Quantifying the cellular NAD+ metabolome using a tandem liquid chromatography mass spectrometry approach', Metabolomics, 14,

Journal articles | 2018

Das A; Huang GX; Bonkowski MS; Longchamp A; Li C; Schultz MB; Kim LJ; Osborne B; Joshi S; Lu Y; Treviño-Villarreal JH; Kang MJ; Hung TT; Lee B; Williams EO; Igarashi M; Mitchell JR; Wu LE; Turner N; Arany Z; Guarente L; Sinclair DA, 2018, 'Impairment of an Endothelial NAD⁺-H2S Signaling Network Is a Reversible Cause of Vascular Aging', Cell, 173, pp. 74 - 89.e20,

Journal articles | 2018

Latorre-Muro P; Baeza J; Armstrong EA; Hurtado-Guerrero R; Corzana F; Wu LE; Sinclair DA; López-Buesa P; Carrodeguas JA; Denu JM, 2018, 'Dynamic Acetylation of Phosphoenolpyruvate Carboxykinase Toggles Enzyme Activity between Gluconeogenic and Anaplerotic Reactions', Molecular Cell, 71, pp. 718 - 732.e9,

Journal articles | 2018

Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', ESMO Open, 3, pp. A25 - A25,

Journal articles | 2017

Chowdhury MKH; Turner N; Bentley NL; Das A; Wu LE; Richani D; Bustamante S; Gilchrist RB; Morris MJ; Shepherd PR; Smith GC; Chowdhury M, 2017, 'Niclosamide reduces glucagon sensitivity via hepatic PKA inhibition in obese mice: Implications for glucose metabolism improvements in type 2 diabetes', Scientific Reports, 7, pp. 40159,

Journal articles | 2017

Das A; Sinclair D; Bonkowski M; Johnston I; Wu L, 2017, 'Extension of physical endurance and protection against physical, chemical and radiological trauma by NAD + precursors', Journal of Science and Medicine in Sport, 20, pp. S165 - S166,

Journal articles | 2017

Nelson ME; Lahiri S; Chow JDY; Byrne FL; Hargett SR; Breen DS; Olzomer EM; Wu LE; Cooney GJ; Turner N; James DE; Slack-Davis JK; Lackner C; Caldwell SH; Hoehn KL, 2017, 'Inhibition of hepatic lipogenesis enhances liver tumorigenesis by increasing antioxidant defence and promoting cell survival', Nature Communications, 8, pp. 14689,

Journal articles | 2016

Awan Z; Tay ESE; Eyre NS; Wu LE; Beard MR; Boo I; Drummer HE; George J; Douglas MW, 2016, 'Calsyntenin-1 mediates hepatitis C virus replication', Journal of General Virology, 97, pp. 1877 - 1887,

Journal articles | 2016

Cagnone GLM; Tsai TS; Makanji Y; Matthews P; Gould J; Bonkowski MS; Elgass KD; Wong ASA; Wu LE; McKenzie M; Sinclair DA; John JCS, 2016, 'Restoration of normal embryogenesis by mitochondrial supplementation in pig oocytes exhibiting mitochondrial DNA deficiency', Scientific Reports, 6,

Journal articles | 2016

Chowdhury MKH; Wu LE; Coleman JLJ; Smith NJ; Morris MJ; Shepherd PR; Smith GC; Chowdhury M, 2016, 'Niclosamide blocks glucagon phosphorylation of Ser⁵⁵² on β-catenin in primary rat hepatocytes via PKA signalling', Biochemical Journal, 473, pp. 1247 - 1255,

Journal articles | 2016

Mohamad M; Mitchell SJ; Wu LE; White MY; Cordwell SJ; Mach J; Solon-Biet SM; Boyer D; Nines D; Das A; Catherine Li SY; Warren A; Hilmer SN; Fraser R; Sinclair DA; Simpson SJ; de Cabo R; Le Couteur DG; Cogger VC, 2016, 'Ultrastructure of the liver microcirculation influences hepatic and systemic insulin activity and provides a mechanism for age-related insulin resistance', Aging Cell, 15, pp. 706 - 715,

Journal articles | 2016

Pratap CB; Scanu T; Spaapen RM; Bakker JM; Wu L-E; Hofland I; Broeks A; Shukla VK; Kumar M; Janssen H; Song J-Y; Riele HT; Holden DW; Nath G; Neefjes J, 2016, 'Salmonella manipulation of host signalling pathways promotes cellular transformation and cancer of infected tissues', International Journal of Infectious Diseases, 45, pp. 145 - 145,

Journal articles | 2016

Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie - International Edition, 55, pp. 1742 - 1745,

Journal articles | 2016

Wu LE; Levina A; Harris HH; Cai Z; Lai B; Vogt S; James DE; Lay PA, 2016, 'Carcinogenic Chromium(VI) Compounds Formed by Intracellular Oxidation of Chromium(III) Dietary Supplements by Adipocytes', Angewandte Chemie, 128, pp. 1774 - 1777,

Journal articles | 2016

Wu LE; Sinclair DA, 2016, 'Restoring stem cells-all you need is NAD⁺', Cell Research, 26, pp. 971 - 972,

Journal articles | 2015

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair D; 91��˰涶��r H, 2015, 'Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes', PLoS ONE, 10, pp. e0130058,

Journal articles | 2015

Riepsamen A; Wu L; Lau L; Listijono D; Ledger W; Sinclair DA; 91��˰涶��r H, 2015, 'Erratum: Nicotinamide impairs entry into and exit from meiosis I in mouse oocytes (PLoS ONE (2015) 10:5 (e0126194) DOI:10.1371/journal.pone.0126194)', PLoS ONE, 10, pp. e0126194,

Journal articles | 2015

Wu LE; Fazakerley DJ; Cantley J, 2015, 'Circulating AFABP promotes insulin secretion', Obesity, 23, pp. 1525,

Journal articles | 2014

Ma X; Yang P; Kaplan WH; Lee BH; Wu LE; Yang JYH; Yasunaga M; Sato K; Chisholm DJ; James DE, 2014, 'ISL1 regulates peroxisome proliferator-activated receptor γ activation and early adipogenesis via bone morphogenetic protein 4-dependent and -independent mechanisms', Molecular and Cellular Biology, 34, pp. 3607 - 3617,

Journal articles | 2014

North BJ; Rosenberg MA; Jeganathan KB; Hafner AV; Michan S; Dai J; Baker DJ; Cen Y; Wu LE; Sauve AA; Van Deursen JM; Rosenzweig A; Sinclair DA, 2014, 'SIRT2 induces the checkpoint kinase BubR1 to increase lifespan', EMBO Journal, 33, pp. 1438 - 1453,

Journal articles | 2014

Solon-Biet SM; McMahon AC; Ballard JWO; Ruohonen K; Wu LE; Cogger VC; Warren A; Huang X; Pichaud N; Melvin RG; Gokarn R; Khalil M; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'The ratio of macronutrients, not caloric intake, dictates cardiometabolic health, aging, and longevity in ad libitum-fed mice', Cell Metabolism, 19, pp. 418 - 430,

Journal articles | 2014

Wu LE; Gomes AP; Sinclair DA, 2014, 'Geroncogenesis: Metabolic Changes during Aging as a Driver of Tumorigenesis', Cancer Cell, 25, pp. 12 - 19,

Journal articles | 2014

Wu LE; Meoli CC; Mangiafico SP; Fazakerley DJ; Cogger VC; Mohamad M; Pant H; Kang MJ; Powter E; Burchfield JG; Xirouchaki CE; Mikolaizak AS; Stöckli J; Kolumam G; Van Bruggen N; Gamble JR; Le Couteur DG; Cooney GJ; Andrikopoulos S; James DE, 2014, 'Systemic VEGF-A neutralization ameliorates diet-induced metabolic dysfunction', Diabetes, 63, pp. 2656 - 2667,

Journal articles | 2014

Wu LE; Samocha-Bonet D; Whitworth PT; Fazakerley DJ; Turner N; Biden TJ; James DE; Cantley J, 2014, 'Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity', Molecular Metabolism, 3, pp. 465 - 473,

Journal articles | 2014

Wu LE; Sinclair DA, 2014, 'SIRT2 controls the pentose phosphate switch', EMBO Journal, 33, pp. 1287 - 1288,

Journal articles | 2014

Wu LE; Solon S; McMahon AC; Ballard JWO; Ruohonen K; Cogger VC; Warren A; Pichaud N; Melvin RG; Gokarn R; Khalil M; Huang X; Turner N; Cooney GJ; Sinclair DA; Raubenheimer D; Le Couteur DG; Simpson SJ, 2014, 'Disparate consequences of macronutrients on appetite, longevity and cardiometabolic health reconciled by nutritional geometry', Cell Metabolism

Journal articles | 2013

Poorten DVD; Samer CF; Ramezani-Moghadam M; Coulter S; Kacevska M; Schrijnders D; Wu LE; McLeod D; Bugianesi E; Komuta M; Roskams T; Hebbard L; George J, 2013, 'Hepatic fat loss in advanced nonalcoholic steatohepatitis: Are alterations in serum adiponectin the cause?†', Hepatology,

Journal articles | 2010

Hocking SL; Wu LE; Guilhaus M; Chisholm DJ; James DE, 2010, 'Intrinsic depot-specific differences in the secretome of adipose tissue, preadipocytes, and adipose tissue-derived microvascular endothelial cells', Diabetes, 59, pp. 3008 - 3016,

Journal articles | 2010

Wu LE; Carter EA; Rayner BS; McLeod AI; Marshall CP; Levina A; Aitken JB; Witting PK; Lai B; Cai Z; Vogt S; Lee YC; Tobin MJ; Harris HH; Lay PA, 2010, 'Silicon Nitride as a Versatile Growth Substrate for Microspectroscopic Imaging and Mapping of Individual Cells.', Molecular Biosystems, 6, pp. 1316 - 1322

Journal articles | 2010

Wu LE; Hocking SL; James DE, 2010, 'Macrophage infiltration and cytokine release in adipose tissue: angiogenesis or inflammation?', Diabetology International, 1, pp. 26 - 34,

Journal articles | 2009

Crowe SM; Wu LE; Economou C; Turpin S; Matzaris M; Hoehn KL; Hevener A; James DE; Duh E; Watt M, 2009, 'Pigment Epithelium-Derived Factor Contributes to Insulin Resistance in Obesity', Cell Metabolism, 10, pp. 40 - 47

Journal articles | 2009

Zhang SH; Chen XY; Wong KS; Leung T; Wu LE; Fan XJ, 2009, 'FP08-MO-02 Compliance of patients with guideline in secondary prevention of stroke: a multicentre study in China', Journal of the Neurological Sciences, 285, pp. S69 - S69,

Journal articles | 2008

Hoehn K; Hohnen-Behrens C; Cederberg A; Wu LE; Turner N; Yuasa T; Ebina Y; James DE, 2008, 'IRS1-independent defects define major nodes of insulin resistance', Cell Metabolism, 7, pp. 421 - 433,

Journal articles | 2007

Vogt S; Lai B; Finney L; Palmer B; Wu LE; Harris H; Paunesku T; de Jonge M; Legnini D; Maser J; Glesne D; Lay P; Woloschak G, 2007, 'Imaging trace elements in cells with x-ray fluorescence microscopy', MICROSCOPY AND MICROANALYSIS, 13, pp. 40 - 41,
Working Papers | 2019

Bertoldo MJ; Listijono DR; Ho W-HJ; Riepsamen AH; Jin XL; Selesniemi K; Goss DM; Mahbub S; Campbell JM; Habibalahi A; Loh W-GN; Youngson NA; Maniam J; Wong ASA; Richani D; Li C; Zhao Y; Marinova M; Kim L-J; Lau L; Wu RM; Mikolaizak AS; Araki T; Le Couteur DG; Turner N; Morris MJ; Walters KA; Goldys E; O’Neill C; Gilchrist RB; Sinclair DA; 91��˰涶��r HA; Wu LE, 2019, NAD+ repletion rescues female fertility during reproductive ageing, Cold Spring Harbor Laboratory,
Preprints | 2024

Madawala R; Banks JL; Hancock SE; Quek L-E; Turner N; Wu LE, 2024, CD38 mediates nicotinamide mononucleotide (NMN) base exchange to yield nicotinic acid mononucleotide (NaMN),

Patents | 2022

Wu L; Sinclair D, 2022, Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity, Patent No. Belgium, Denmark, Europe, France, Germany, Ireland, Italy, Netherlands, Poland, Portugal, Spain, Sweden, Switzerland, United Kingdom - 3288637; Japan - 7193232; United States - 11389469

Preprints | 2021

Habibalahi A; Bertoldo M; Mahbub S; Campbell J; Goss D; Ledger W; Gilchrist R; Wu L; Goldys E, 2021, NMN treatment reverses unique deep radiomic signature morphology of oocytes from aged mice,

Conference Papers | 2021

Mahbub SB; Campbell J; Tan TCY; Habibalahi A; Bertoldo MJ; Goss DM; Walter K; Wu LE; Dunning KR; Goldys E, 2021, 'Label-free multispectral identification of native fluorophores to assess embryo and oocyte quality', in Leary JF; Tarnok A; Georgakoudi I (eds.), Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, SPIE, presented at Imaging, Manipulation, and Analysis of Biomolecules, Cells, and Tissues XIX, 06 March 2021 - 12 March 2021,

Preprints | 2020

Kim L-J; Chalmers T; Smith G; Li C; Das A; Poon WKE; Wang J; Tucker S; Sinclair D; Quek L-E; Wu L, 2020, Nicotinamide mononucleotide (NMN) deamidation and indirect regulation of the NAD metabolome, ,

Conference Abstracts | 2020

Murphy T; Wu L; Sandow S; Das A; Naim H, 2020, 'Effect of Dietary Nicotinamide Mononucleotide (NMN) on Function and Mechanics of Skeletal Muscle Arteries from Aged Mice', in FASEB JOURNAL, WILEY, CA, San Diego, Vol. 34, presented at Annual Meeting on Experimental Biology, CA, San Diego, 04 April 2020 - 07 April 2020,

Patents | 2020

Wu L; Sinclair D, 2020, Targeting NAD+ to treat chemotherapy and radiotherapy induced cognitive impairment, neuropathies and inactivity, Patent No. United Stated Patent no. 10603334

Conference Papers | 2019

Riepsamen A; Listijono D; Kalani S; Cooke S; Ledger W; Wu L; Sinclair D, 2019, 'Sirtuins are required for forming fertilization-ready eggs', BJOG: An International Journal of Obstetrics & Gynaecology, Brisbane, Australia, presented at Royal College of Obstetricians and Gynaecologists World Congress, Brisbane, Australia, 10 April 2019,

Patents | 2018

Sinclair D; Gomes A; Wu L, 2018, NAD biosynthesis and precursors for the treatment and prevention of cancer and proliferation, Patent No. 9877981,

Conference Abstracts | 2018

Sultani G; Bentley N; Osborne B; Joshi S; Araki T; Montgomery M; Polly P; Byrne F; Wu L; Turner N, 2018, 'PO-011 Impact of compartment-specific changes in NAD biosynthesis on diethylnitrosamine-induced liver cancer', in ESMO Open, Elsevier BV, Vol. 3, pp. A25 - A25,

Conference Abstracts | 2017

Chowdhury MKH; Morris M; Turner N; Wu L; Shepherd P; Smith G, 2017, 'Niclosamide blocks glucagon phosphorylation of serine 552 on beta-catenin leading to decrease target genes expression and improve glucose metabolism via PKA signalling pathway', in FASEB JOURNAL, WILEY, IL, Chicago, Vol. 31, presented at Experimental Biology (EB) Annual Meeting, IL, Chicago, 22 April 2017 - 26 April 2017,

Conference Papers | 2015

91��˰涶��r H; Riepsamen A; Wu LE; Sinclair D, 2015, 'Sirt2-mediated BubR1 regulation promotes oocyte maturation', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, PORTUGAL, Lisbon, pp. 11 - 11, presented at 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), PORTUGAL, Lisbon, 14 June 2015 - 17 June 2015,

Conference Papers | 2015

Riepsamen A; Listijono D; Ledger W; Wu L; Sinclair D; 91��˰涶��r H, 2015, 'Inhibition of sirtuin activity and impaired synthesis of the sirtuin NAD plus co-factor disrupts oocyte meiotic maturation', in HUMAN REPRODUCTION, OXFORD UNIV PRESS, PORTUGAL, Lisbon, pp. 309 - 309, presented at 31st Annual Meeting of the European-Society-of-Human-Reproduction-and-Embryology (ESHRE), PORTUGAL, Lisbon, 14 June 2015 - 17 June 2015,

Conference Papers | 2014

Cogger V; Mohamad M; Wu L; De Cabo R; Le Couteur DG, 2014, 'DEFENESTRATION OF THE LIVER SINUSOIDAL ENDOTHELIAL CELL IMPAIRS INSULIN AND GLUCOSE UPTAKE', in GERONTOLOGIST, OXFORD UNIV PRESS INC, pp. 164 - 164,

Conference Papers | 2010

Wu LE; James DE; Cantley J, 2010, 'Secreted adipocyte fatty acid binding protein (FABP4) forms the molecular basis of the adipo-insular axis', in DIABETOLOGIA, SPRINGER, SWEDEN, Stockholm, pp. S58 - S58, presented at 46th Annual Meeting of the European-Association-for-the- Study-of-Diabetes (EASD), SWEDEN, Stockholm, 20 September 2010 - 24 September 2010,

Conference Papers | 2009

Wu LE; Larance M; Ramm G; Raftery M; Guilhaus M; James DE, 2009, 'Proteomic Analysis of Adipokine Secretion in Insulin Resistance', in DIABETES, AMER DIABETES ASSOC, LA, New Orleans, pp. A333 - A334, presented at 69th Annual Meeting of the American-Diabetes-Association, LA, New Orleans, 05 June 2009 - 09 June 2009,

"Media formulations to enhance embryo formation in assisted reproduction": NHMRC Development Grant (2021-2023)

“Translating new advances in oncofertility”: NHMRC Project Grant APP1139763, (2018-2021).

“Preserving ovarian function during chemotherapy and old age”: NHMRC Career Development Fellowship (RD Wright Biomedical Fellowship) APP1127821 (2017-2020)

“Nicotinamide adenine dinucleotide (NAD+) raising agents for improving oocyte quality”: NHMRC Development Grant APP1122484 (2017-2019)

“Female reproductive health preservation by nicotinamide adenine dinucleotide (NAD+) and Sirtuin2 (SIRT2)”: NHMRC Project Grant APP1103689��(2016-2018)

“New drugs to prevent premature ageing and side effects of chemotherapy”: NHMRC Development Grant APP1093643 (2015-2017)

“Calorie restriction mimetics for the treatment of hepatocellular carcinoma”: Early Career Fellowship, Cancer Institute NSW (2014-2016).��

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The Conversation

Wu, LE (2017). ��Selected for The Conversation Yearbook, "50 Standout Articles from Australia's Top Thinkers"

Wu LE, Mikolaizak AS (2017). ��

Collins C, Wu LE (2016).

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Articles, interviews

ABC News:

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My Research Supervision

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My Teaching

BABS2011 - Current Trends in Biotechnology

BIOC3271 - Molecular Cell Biology II

PHAR2011 - Introductory Pharmacology and Toxicology

PHAR9101 - Introduction to the Therapeutics Industry

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