Associate Professor Maria Markoulli

Associate Professor

PhD MOptom GradCertOcTher FBCLA FAAO

Medicine & Health

School of Optometry and Vision Science

Dr Maria Markoulli is an Optometrist and��Associate Professor at the School of Optometry and Vision Science at UNSW.��Her research interests lie within tear film biochemistry and the ocular surface.��In particular, her research goals are to:

understand the impact that systemic disease, such as diabetes, can have on corneal nerves and tear film biochemistry
characterise the impact of dry eye disease and meibomian gland dysfunction��on the ocular surface and identify effective treatments
minimise contact lens-related adverse events

��

��Awards��

2022��Australian Council of Graduate Research Excellence in Graduate Research�� Leadership: Special Commendation
2021 UNSW Vice Chancellor’s Award for Excellence in Higher Degree Research��Leadership
2019 UNSW ARC Postgraduate Supervisor Award
2019 UNSW Women in Maths and Science Champion
2019 UNSW School of Optometry and Vision Science Research Excellence Award
2017 UNSW Vice-Chancellor's Award for Teaching Excellence
2016 Juvenile Diabetes Research Foundation travel grant
2015 Certificate for Teaching Excellence (Faculty of Science, UNSW)
64^th Meeting of the Nobel Laureates, Lindau, Germany: Selected by the Group of Eight and the Australian Academy of Science to attend, 2014
UNSW Early Career Researchers grant 2013
William C. Ezell Fellowship (American Optometric Foundation), 2009 & 2010
OVRF-Maki Shiobara Scholarship, 2010��
Tear Film and Ocular Surface Travel Award, 2010
Cornea and Contact Lens Society of Australia Scholarship, 2010
Postgraduate Research Scheme Scholarship, 2010
Australian Postgraduate Award (Australian Government), 2008-2011
Ciba Vision Pty Ltd Prize for Excellence in Contact Lenses, 2004
David Bard Scholarship (University of New South Wales), 2002
Faculty of Science Scholarship for 4 years (University of New South Wales), 2000-2003

Teaching

OPTM6400: Course convenor for 'Optometric Preclinical Practice' in Term 1 (MClinOptom students)
Academic lead for the UNSW Dry Eye Clinic
Dry eye lectures

Engagement and Leadership

Director of Learning and Teaching
Postgraduate Coordinator 2017-2022
Deputy Editor:��Clinical and Experimental Optometry
Board member: The Optical Foundation
Tear Film and Ocular Surface (TFOS) Young Investigator committee member
TFOS International Workshop on Contact Lens Discomfort Subcommittee member
TFOS Dry Eye Workshop II Subcommittee member
TFOS "A lifestyle epidemic: ocular surface disease" Steering Committee member and Sub-committee chair

Professional memberships

Optometrists Association of Australia
Ezell Club, American Optometric Foundation
Fellow and Member of the American Academy of Optometry
Fellow and Member of British Contact Lens Association
Member and Councillor of the International Society of Contact Lens Researchers
TFOS
Association for researchers in vision and ophthalmology

Research Groups

Dry eye: contact lens wear, innervation and symptoms
Ocular surface disease: biomarkers, diabetes, obesity and nutrition, multiple sclerosis, migraines, chemotherapy-induced peripheral neuropathy
Tear film biochemistry, ocular homeostasis and pathology

Phone

+612 9065 7355

E-mail

m.markoulli@unsw.edu.au

Location

School of Optometry and Vision Science, University of New South Wales Level 3 North Wing Rupert Myers Building, Gate 14 Barker Street, UNSW Sydney NSW 2052 Australia

Journal articles | 2024

Alotaibi S; Papas E; Mobeen R; Ozkan J; Misra SL; Markoulli M, 2024, 'Tear film hTERT and corneal nerve characteristics in dry eye disease', Clinical and Experimental Optometry,

Journal articles | 2024

Asiedu K; Tummanapalli SS; Alotaibi S; Wang LL; Dhanapalaratnam R; Kwai N; Poynten A; Markoulli M; Krishnan AV, 2024, 'Impact of SGLT2 Inhibitors on Corneal Nerve Morphology and Dendritic Cell Density in Type 2 Diabetes', Ocular Immunology and Inflammation, 32, pp. 234 - 241,

Journal articles | 2024

Markoulli M; Fricke TR; Arvind A; Frick KD; Hart KM; Joshi MR; Kandel H; Filipe Macedo A; Makrynioti D; Retallic N; Garcia-Porta N; Shrestha G; Wolffsohn JS, 2024, 'BCLA CLEAR Presbyopia: Epidemiology and impact', Contact Lens and Anterior Eye, 47,

Journal articles | 2024

Morgan PB; Efron N; Papas E; Barnett M; Carnt N; Dutta D; Hepworth A; Little JA; Nagra M; Pult H; Schweizer H; Shen Lee B; Subbaraman LN; Sulley A; Thompson A; Webster A; Markoulli M, 2024, 'BCLA CLEAR Presbyopia: Management with contact lenses and spectacles', Contact Lens and Anterior Eye, 47,

Journal articles | 2024

Tummanapalli SS; Wang LL; Dhanapalaratnam R; Poynten A; Papas EB; Krishnan AV; Markoulli M, 2024, 'Moderate-severe peripheral neuropathy in diabetes associated with an increased risk of dry eye disease', Optometry and Vision Science, 101, pp. 563 - 570,

Journal articles | 2024

Wolffsohn JS; Naroo SA; Bullimore MA; Craig JP; Davies LN; Markoulli M; Schnider C; Morgan PB, 2024, 'BCLA CLEAR Presbyopia: Definitions', Contact Lens and Anterior Eye, 47,

Journal articles | 2023

Alotaibi S; Papas E; Ozkan J; Misra SL; Markoulli M, 2023, 'Behaviour of hTERT in the tears of neophyte contact lens wearers during the sleep/wake cycle', Contact Lens and Anterior Eye, 46,

Journal articles | 2023

Asiedu K; Alotaibi S; Krishnan AV; Kwai N; Poynten A; Markoulli M; Dhanapalaratnam R, 2023, 'Chronic Kidney Disease Has No Impact on Tear Film Substance P Concentration in Type 2 Diabetes', Biomedicines, 11,

Journal articles | 2023

Asiedu K; Krishnan AV; Kwai N; Poynten A; Markoulli M, 2023, 'Conjunctival microcirculation in ocular and systemic microvascular disease', Clinical and Experimental Optometry, 106, pp. 694 - 702,

Journal articles | 2023

Asiedu K; Markoulli M; Tummanapalli SS; Chiang JCB; Alotaibi S; Wang LL; Dhanapalaratnam R; Kwai N; Poynten A; Krishnan AV, 2023, 'Impact of Chronic Kidney Disease on Corneal Neuroimmune Features in Type 2 Diabetes', Journal of Clinical Medicine, 12,

Journal articles | 2023

Chiang JCB; Roy M; Kim J; Markoulli M; Krishnan AV, 2023, 'In-vivo corneal confocal microscopy: Imaging analysis, biological insights and future directions', Communications Biology, 6,

Journal articles | 2023

Craig JP; Alves M; Wolffsohn JS; Downie LE; Efron N; Galor A; Gomes JAP; Jones L; Markoulli M; Stapleton F; Starr CE; Sullivan AG; Willcox MDP; Sullivan DA, 2023, 'TFOS Lifestyle Report Executive Summary: A Lifestyle Epidemic - Ocular Surface Disease', Ocular Surface, 30, pp. 240 - 253,

Journal articles | 2023

Craig JP; Alves M; Wolffsohn JS; Downie LE; Efron N; Galor A; Gomes JAP; Jones L; Markoulli M; Stapleton F; Starr CE; Sullivan AG; Willcox MDP; Sullivan DA, 2023, 'TFOS Lifestyle Report Introduction: A Lifestyle Epidemic - Ocular Surface Disease', Ocular Surface, 28, pp. 304 - 309,

Journal articles | 2023

Markoulli M; Ahmad S; Arcot J; Arita R; Benitez-del-Castillo J; Caffery B; Downie LE; Edwards K; Flanagan J; Labetoulle M; Misra SL; Mrugacz M; Singh S; Sheppard J; Vehof J; Versura P; Willcox MDP; Ziemanski J; Wolffsohn JS, 2023, 'TFOS Lifestyle: Impact of nutrition on the ocular surface: TFOS Lifestyle Workshop: Nutrition report', Ocular Surface, 29, pp. 226 - 271,

Journal articles | 2023

Md��Isa NA; Tummanapalli SS; Chiang JCB; Krishnan AV; Zagami AS; Papas EB; Markoulli M; Spira K, 2023, 'Neuropathic changes in corneal nerve endings—A potential objective biomarker for migraine frequency and response to treatment', Headache, 63, pp. 1327 - 1329,

Journal articles | 2023

Sullivan DA; da Costa AX; Del Duca E; Doll T; Grupcheva CN; Lazreg S; Liu SH; McGee SR; Murthy R; Narang P; Ng A; Nistico S; O'Dell L; Roos J; Shen J; Markoulli M, 2023, 'TFOS Lifestyle: Impact of cosmetics on the ocular surface', Ocular Surface, 29, pp. 77 - 130,

Journal articles | 2022

Alotaibi S; Markoulli M; Ozkan J; Papas E, 2022, 'Bio-chemical markers of chronic, non-infectious disease in the human tear film', Clinical and Experimental Optometry, 105, pp. 166 - 176,

Journal articles | 2022

Alotaibi S; Ozkan J; Papas E; Markoulli M, 2022, 'Diurnal Variation of Corneal Dendritic Cell Density', Current Eye Research, 47, pp. 1239 - 1245,

Journal articles | 2022

Asiedu K; Dhanapalaratnam R; Krishnan AV; Kwai N; Poynten A; Markoulli M, 2022, 'Impact of Peripheral and Corneal Neuropathy on Markers of Ocular Surface Discomfort in Diabetic Chronic Kidney Disease', Optometry and Vision Science, 99, pp. 807 - 816,

Journal articles | 2022

Asiedu K; Markoulli M; Bonini S; Bron AJ; Dogru M; Kwai N; Poynten A; Willcox MDP; Krishnan AV, 2022, 'Tear film and ocular surface neuropeptides: Characteristics, synthesis, signaling and implications for ocular surface and systemic diseases', Experimental Eye Research, 218,

Journal articles | 2022

Chiang JCB; Arnold R; Dhanapalaratnam R; Markoulli M; Krishnan AV, 2022, 'Current and Emerging Pharmacotherapeutic Interventions for the Treatment of Peripheral Nerve Disorders', Pharmaceuticals, 15, pp. 607,

Journal articles | 2022

Chiang JCB; Goldstein D; Trinh T; Au K; Park SB; Krishnan AV; Markoulli M, 2022, 'Tear film substance P in patients treated with neurotoxic chemotherapy', Experimental Eye Research, 224,

Journal articles | 2022

Chiang JCB; Khou V; Tavakoli A; Park SB; Goldstein D; Krishnan AV; Markoulli M, 2022, 'Reproducibility and Reliability of Subbasal Corneal Nerve Parameters of the Inferior Whorl in the Neurotoxic and Healthy Cornea', Cornea, 41, pp. 1487 - 1494,

Journal articles | 2022

Chiang JCB; Krishnan AV; Goldstein D; Markoulli M, 2022, 'The Impact of Post-Tear Collection Storage on Tear Film Substance P Concentration', Current Eye Research, 47, pp. 1116 - 1120,

Journal articles | 2022

Dhanapalaratnam R; Markoulli M; Krishnan AV, 2022, 'Disorders of vision in multiple sclerosis', Clinical and Experimental Optometry, 105, pp. 3 - 12,

Journal articles | 2022

Edwards K; Dehghani C; Markoulli M, 2022, 'Ocular implications of systemic disease', Clinical and Experimental Optometry, 105, pp. 103 - 104,

Journal articles | 2022

Klisser J; Tummanapalli SS; Kim J; Chiang JCB; Khou V; Issar T; Naduvilath T; Poynten AM; Markoulli M; Krishnan AV, 2022, 'Automated analysis of corneal nerve tortuosity in diabetes: implications for neuropathy detection', Clinical and Experimental Optometry, 105, pp. 487 - 493,

Journal articles | 2022

Markoulli M; Wong K; Jia T; Siddireddy JS; Briggs N; Tan J, 2022, 'The effect of hydroxypropyl-guar nanoemulsion on signs and symptoms of dry eye', Contact Lens and Anterior Eye, 45,

Journal articles | 2022

Tavakoli A; Markoulli M; Flanagan J; Papas E, 2022, 'The validity of point of care tear film osmometers in the diagnosis of dry eye', Ophthalmic and Physiological Optics, 42, pp. 140 - 148,

Journal articles | 2022

Tavakoli A; Markoulli M; Papas E; Flanagan J, 2022, 'The Impact of Probiotics and Prebiotics on Dry Eye Disease Signs and Symptoms', Journal of Clinical Medicine, 11,

Journal articles | 2021

Alghamdi WM; Markoulli M; Papas EB, 2021, 'Filaggrin Expression in the Lid Margin During Contact Lens Wear', Eye and Contact Lens, 47, pp. 638 - 641,

Journal articles | 2021

Chiang JCB; Goldstein D; Park SB; Krishnan AV; Markoulli M, 2021, 'Corneal nerve changes following treatment with neurotoxic anticancer drugs', Ocular Surface, 21, pp. 221 - 237,

Journal articles | 2021

Chiang JCB; Goldstein D; Tavakoli A; Trinh T; Klisser J; Lewis CR; Friedlander M; Naduvilath TJ; Au K; Park SB; Krishnan AV; Markoulli M, 2021, 'Corneal dendritic cells and the subbasal nerve plexus following neurotoxic treatment with oxaliplatin or paclitaxel', Scientific Reports, 11, pp. 22884,

Journal articles | 2021

Chiang JCB; Goldstein D; Trinh T; Au K; Mizrahi D; Muhlmann M; Crowe P; O’neill S; Edwards K; Park SB; Krishnan AV; Markoulli M, 2021, 'A cross-sectional study of sub-basal corneal nerve reduction following neurotoxic chemotherapy', Translational Vision Science and Technology, 10, pp. 1 - 11,

Journal articles | 2021

Chiang JCB; Goldstein D; Trinh T; Au K; Park SB; Krishnan AV; Markoulli M, 2021, 'A cross-sectional study of ocular surface discomfort and corneal nerve dysfunction after paclitaxel treatment for cancer', Scientific Reports, 11, pp. 1786,

Journal articles | 2021

Issar T; Tummanapalli SS; Borire AA; Kwai NCG; Poynten AM; Arnold R; Markoulli M; Krishnan AV, 2021, 'Impact of the metabolic syndrome on peripheral nerve structure and function in type 2 diabetes', European Journal of Neurology, 28, pp. 2074 - 2082,

Journal articles | 2021

Khou V; Ly A; Moore L; Markoulli M; Kalloniatis M; Yapp M; Hennessy M; Zangerl B, 2021, 'Review of referrals reveal the impact of referral content on the triage and management of ophthalmology wait lists', BMJ Open, 11, pp. e047246,

Journal articles | 2021

Li C; Zhou Z; Neuen BL; Yu J; Huang Y; Young T; Li J; Li L; Perkovic V; Jardine MJ; Keay L; Markoulli M; Rosenthal N; Capuano G; Yavin Y; Neal B; Arnott C, 2021, 'Sodium-glucose co-transporter-2 inhibition and ocular outcomes in patients with type 2 diabetes: A systematic review and meta-analysis', Diabetes, Obesity and Metabolism, 23, pp. 252 - 257,

Journal articles | 2021

Markoulli M; Chandramohan N; Papas EB, 2021, 'Photobiomodulation (low-level light therapy) and dry eye disease', Clinical and Experimental Optometry, 104, pp. 561 - 566,

Journal articles | 2021

Markoulli M; Fedtke C; Coroneo M; Kalloniatis M; Whatham A; Yapp M; Zangerl B, 2021, 'Clinical utility of irx3 in keratoconus', Clinical and Experimental Optometry, 104, pp. 107 - 114,

Journal articles | 2021

Ross E; Furniss E; Chandramohan N; Markoulli M, 2021, 'The multi-faceted approach to dry eye disease', Clinical and Experimental Optometry, 104, pp. 417 - 420,

Journal articles | 2020

Alghamdi W; Markoulli M; Papas E, 2020, 'The relationship between tear film MMP-9 and meibomian gland changes during soft contact lens wear', Contact Lens and Anterior Eye, 43, pp. 154 - 158,

Journal articles | 2020

Chiang JCB; Zahari I; Markoulli M; Krishnan AV; Park SB; Semmler A; Goldstein D; Edwards K, 2020, 'The impact of anticancer drugs on the ocular surface', Ocular Surface, 18, pp. 403 - 417,

Journal articles | 2020

Issar T; Tummanapalli SS; Kwai NCG; Chiang JCB; Arnold R; Poynten AM; Markoulli M; Krishnan AV, 2020, 'Associations between acute glucose control and peripheral nerve structure and function in type 1 diabetes', Diabetic Medicine, 37, pp. 1553 - 1560,

Journal articles | 2020

Markoulli M; Colorado LH; Edwards K, 2020, 'The Relationship between Corneal Nerve Morphology and Inflammatory Mediators and Neuropeptides in Healthy Individuals', Optometry and Vision Science, 97, pp. 145 - 153,

Journal articles | 2020

Markoulli M; Jalbert I, 2020, 'Scientia Professor Fiona Stapleton: leading academic and world‐renowned epidemiologist of contact lens‐related eye disease', Clinical and Experimental Optometry, 103, pp. 552 - 554,

Journal articles | 2020

Markoulli M, 2020, 'Women in optometry and vision science', Clinical and Experimental Optometry, 103, pp. 131 - 132,

Journal articles | 2020

Mehrgardt P; Zandavi SM; Poon SK; Kim J; Markoulli M; Khushi M, 2020, 'U-net segmented adjacent angle detection (Usaad) for automatic analysis of corneal nerve structures', Data, 5,

Journal articles | 2020

Tummanapalli SS; Issar T; Kwai N; Pisarcikova J; Poynten AM; Krishnan AV; Willcox MDP; Markoulli M, 2020, 'A Comparative Study on the Diagnostic Utility of Corneal Confocal Microscopy and Tear Neuromediator Levels in Diabetic Peripheral Neuropathy', Current Eye Research, 45, pp. 921 - 930,

Journal articles | 2020

Tummanapalli SS; Issar T; Kwai N; Poynten A; Krishnan AV; Willcox M; Markoulli M, 2020, 'Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes', Clinical Neurophysiology, 131, pp. 145 - 154,

Journal articles | 2020

Tummanapalli SS; Issar T; Kwai N; Poynten A; Krishnan AV; Willcox M; Markoulli M, 2020, 'Erratum to ‘Association of corneal nerve loss with markers of axonal ion channel dysfunction in type 1 diabetes’. (Clinical Neurophysiology (2020) 131(1) (145–154), (S1388245719312726), (10.1016/j.clinph.2019.09.029))', Clinical Neurophysiology, 131, pp. 780,

Journal articles | 2020

Tummanapalli SS; Issar T; Yan A; Kwai N; Poynten AM; Krishnan AV; Willcox MDP; Markoulli M, 2020, 'Corneal nerve fiber loss in diabetes with chronic kidney disease', Ocular Surface, 18, pp. 178 - 185,

Journal articles | 2020

Tummanapalli SS; Willcox MDP; Issar T; Kwai N; Poynten AM; Krishnan AV; Pisarcikova J; Markoulli M, 2020, 'The Effect of Age, Gender and Body Mass Index on Tear Film Neuromediators and Corneal Nerves', Current Eye Research, 45, pp. 411 - 418,

Journal articles | 2020

Yan A; Issar T; Tummanapalli SS; Markoulli M; Kwai NCG; Poynten AM; Krishnan AV, 2020, 'Relationship between corneal confocal microscopy and markers of peripheral nerve structure and function in Type 2 diabetes', Diabetic Medicine, 37, pp. 326 - 334,

Journal articles | 2019

Bron AJ; de Paiva CS; Chauhan SK; Bonini S; Gabison EE; Jain S; Knop E; Markoulli M; Ogawa Y; Perez V; Uchino Y; Yokoi N; Zoukhri D; Sullivan DA, 2019, 'Corrigendum to “TFOS DEWS II pathophysiology report” (The Ocular Surface (2017) 15(3) (438–510), (S1542012417301349), (10.1016/j.jtos.2017.05.011))', Ocular Surface, 17, pp. 842,

Journal articles | 2019

Colorado LH; Markoulli M; Edwards K, 2019, 'The Relationship Between Corneal Dendritic Cells, Corneal Nerve Morphology and Tear Inflammatory Mediators and Neuropeptides in Healthy Individuals', Current Eye Research, 44, pp. 840 - 848,

Journal articles | 2019

Dutta D; Kim J; Sarkes M; Nath S; Markoulli M, 2019, 'The repeatability of subjective and objective tear ferning assessment and its association with lipid layer thickness, non-invasive tear break-up time and comfort', Contact Lens and Anterior Eye, 42, pp. 420 - 427,

Journal articles | 2019

López-de la Rosa A; Alghamdi WM; Kunnen CME; Lazon de la Jara P; González-García MJ; Markoulli M; Papas EB, 2019, 'Changes in the tarsal conjunctiva viewed by in vivo confocal microscopy are associated with ocular symptoms and contact lens wear', Ophthalmic and Physiological Optics, 39, pp. 328 - 336,

Journal articles | 2019

Markoulli M; Hui A, 2019, 'Emerging targets of inflammation and tear secretion in dry eye disease', Drug Discovery Today, 24, pp. 1427 - 1432,

Journal articles | 2019

Markoulli M, 2019, 'Professor Mark Willcox: the 2017 H Barry Collin Research Medallist', Clinical and Experimental Optometry, 102, pp. 349,

Journal articles | 2019

Tummanapalli SS; Willcox MDP; Issar T; Yan A; Pisarcikova J; Kwai N; Poynten AM; Krishnan AV; Markoulli M, 2019, 'Tear film substance P: A potential biomarker for diabetic peripheral neuropathy', Ocular Surface, 17, pp. 690 - 698,

Journal articles | 2018

Alghamdi W; Markoulli M; Papas E, 2018, 'Responses of contact lens wearers to OSDI and CLDEQ-8 questionnaires', Contact Lens and Anterior Eye, 41, pp. S89 - S89,

Journal articles | 2018

Alghamdi WM; Markoulli M; Papas EB, 2018, 'The Effect of Contact Lens Wear on the Cellular Morphology of the Lid Wiper Area', Optometry and Vision Science, 95, pp. 491 - 497,

Journal articles | 2018

Kim J; Markoulli M, 2018, 'Automatic analysis of corneal nerves imaged using in vivo confocal microscopy', Clinical and Experimental Optometry, 101, pp. 147 - 161,

Journal articles | 2018

Markoulli M; Duong TB; Lin M; Papas E, 2018, 'Imaging the Tear Film: A Comparison Between the Subjective Keeler Tearscope-Plus™ and the Objective Oculus® Keratograph 5M and LipiView® Interferometer', Current Eye Research, 43, pp. 155 - 162,

Journal articles | 2018

Markoulli M; Flanagan J; Tummanapalli SS; Wu J; Willcox M, 2018, 'The impact of diabetes on corneal nerve morphology and ocular surface integrity', Ocular Surface, 16, pp. 45 - 57,

Journal articles | 2018

Markoulli M; Sobbizadeh A; Tan J; Briggs N; Coroneo M, 2018, 'The Effect of Optive and Optive Advanced Artificial Tears on the Healthy Tear Film', Current Eye Research, 43, pp. 588 - 594,

Journal articles | 2018

Wang MTM; Tien L; Han A; Lee JM; Kim D; Markoulli M; Craig JP, 2018, 'Impact of blinking on ocular surface and tear film parameters', Ocular Surface, 16, pp. 424 - 429,

Journal articles | 2017

Bron AJ; de Paiva CS; Chauhan SK; Bonini S; Gabison EE; Jain S; Knop E; Markoulli M; Ogawa Y; Perez V; Uchino Y; Yokoi N; Zoukhri D; Sullivan DA, 2017, 'TFOS DEWS II pathophysiology report', Ocular Surface, 15, pp. 438 - 510,

Journal articles | 2017

Markoulli M; Gokhale M; You J, 2017, 'Substance p in flush tears and schirmer strips of healthy participants', Optometry and Vision Science, 94, pp. 527 - 533,

Journal articles | 2017

Markoulli M; Isa NAMD; Papas EB, 2017, 'Temporal Characteristics of Sodium Fluorescein in the Tear Meniscus', Optometry and Vision Science, 94, pp. 166 - 173,

Journal articles | 2017

Markoulli M; Kolanu S, 2017, 'Contact lens wear and dry eyes: Challenges and solutions', Clinical Optometry, 9, pp. 41 - 48,

Journal articles | 2017

Markoulli M; You J; Kim J; Duong CL; Tolentino JB; Karras J; Lum E, 2017, 'Corneal nerve morphology and tear film substance p in diabetes', Optometry and Vision Science, 94, pp. 726 - 731,

Journal articles | 2016

Alghamdi WM; Markoulli M; Holden BA; Papas EB, 2016, 'Impact of duration of contact lens wear on the structure and function of the meibomian glands', Ophthalmic and Physiological Optics, 36, pp. 120 - 131,

Journal articles | 2016

Flanagan JL; Khandekar N; Zhu H; Watanabe K; Markoulli M; Flanagan JT; Papas E, 2016, 'Glycerol monolaurate inhibits lipase production by clinical ocular isolates without affecting bacterial cell viability', Investigative Ophthalmology and Visual Science, 57, pp. 544 - 550,

Journal articles | 2016

Jimenez S; Hollands M; Palmisano S; Kim J; Markoulli M; McAndrew D; Stamenkovic A; Walsh J; Bos S; Stapley PJ, 2016, 'Age-related effects of increasing postural challenge on eye movement onset latencies to visual targets', Experimental Brain Research, 234, pp. 1599 - 1609,

Journal articles | 2016

Jones LW; Byrne M; Ciolino JB; Legerton J; Markoulli M; Papas E; Subbaraman L, 2016, 'Revolutionary future uses of contact lenses', Optometry and Vision Science, 93, pp. 325 - 327,

Journal articles | 2016

Yeotikar NS; Zhu H; Markoulli M; Nichols KK; Naduvilath T; Papas EB, 2016, 'Functional and morphologic changes of meibomian glands in an asymptomatic adult population', Investigative Ophthalmology and Visual Science, 57, pp. 3996 - 4007,

Journal articles | 2015

Markoulli M; Gokhale M; Chiem J; Lo F; Papas E, 2015, 'The impact of daily disposable contact lens wear on the conjuctival epitithelium', Contact Lens and Anterior Eye, 38, pp. e11 - e11,

Journal articles | 2014

Markoulli M, 2014, 'Seventh International Conference on the Tear Film & Ocular Surface: Basic Science and Clinical Relevance (Taormina, Sicily, September 2013). Highlights from the Platform Sessions', The Ocular Surface, 12, pp. 120 - 133,

Journal articles | 2013

Efron N; Jones L; Bron AJ; Knop E; Arita R; Barabino S; McDermott AM; Villani E; Willcox MDP; Markoulli M, 2013, 'The TFOS International Workshop on Contact Lens Discomfort: Report of the contact lens interactions with the ocular surface and adnexa subcommittee', Investigative Ophthalmology and Visual Science, 54, pp. tfos98 - tfos122,

Journal articles | 2013

Markoulli M; Papas EB; Cole NA; Holden BA, 2013, 'Effect of contact lens wear on the diurnal profile of matrix metalloproteinase 9 in tears', Optometry and Vision Science, 90, pp. 419 - 429,

Journal articles | 2012

Markoulli M; Papas EB; Cole NA; Holden BA, 2012, 'Differential gel electrophoresis of the tear proteome', Optometry and Vision Science, 89, pp. E875 - E883,

Journal articles | 2012

Markoulli M; Papas EB; Cole NA; Holden BA, 2012, 'The diurnal variation of matrix metalloproteinase-9 and its associated factors in human tears', Investigative Ophthalmology and Visual Science, 53, pp. 1479 - 1484,

Journal articles | 2012

Markoulli M, 2012, 'Tear film break-up time in rabbits.', Clinical and experimental optometry,

Journal articles | 2012

Wei EX; Markoulli M; Willcox MD; Zhao Z, 2012, 'Divalent cations in tears, and their influence on tear film stability in humans and rabbits', Investigative Ophthalmology and Visual Science, 53, pp. 3280 - 3285,

Journal articles | 2011

Markoulli M; Francis I; Yong J; Jalbert I; O Hare N; Cole NA; Papas EB, 2011, 'A histopathological study of bulbar conjunctival flaps occurring in 2 contact lens wearers', Cornea, 30, pp. 1037 - 1041,

Journal articles | 2011

Markoulli M; Papas E; Cole N; Holden B, 2011, 'From a neophyte to an experienced wearer: how adaptation to contact lens wear changes the composition of the tear film', Contact Lens and Anterior Eye, 34, pp. S13 - S13,

Journal articles | 2011

Markoulli M; Papas EB; Cole NA; Holden BA, 2011, 'Corneal erosions in contact lens wear', Contact Lens and Anterior Eye, 35, pp. 2 - 8,

Journal articles | 2011

Markoulli M; Papas EB; Petznick A; Holden BA, 2011, 'Validation of the flush method as an alternative to basal or reflex tear collection', Current Eye Research, 36, pp. 198 - 207,

Journal articles | 2011

Petznick A; Evans MDM; Madigan MC; Markoulli M; Garrett Q; Sweeney DF, 2011, 'A comparison of basal and eye-flush tears for the analysis of cat tear proteins', ACTA Ophthalmologica Scandinavica, 89, pp. e75 - e81,

Journal articles | 2009

Sankaridurg P; Markoulii M; de La Jara PL; Willcox MD; Harmis N; Thomas V; Holden BA, 2009, 'Lid and conjunctival microbiota during contact lens wear in children', Optometry and Vision Science, 86, pp. 312 - 317

Journal articles | 2005

Herse PR; Hans A; Hall J; Langejans J; Markoulli M, 2005, 'The Proview Eye Pressure Monitor: influence of clinical factors on accuracy and agreement with the Goldmann tonometer', Ophthalmic and Physiological Optics, 25, pp. 416 - 420
Conference Papers | 2021

Chiang JCB; Khou V; Tavakoli A; Goldstein D; Krishnan AV; Markoulli M, 2021, 'Corneal inferior whorl morphology and reproducibility with in-vivo confocal microscopy in peripheral neuropathy', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ELECTR NETWORK, presented at ARVO Imaging in the Eye Conference, ELECTR NETWORK, 13 May 2021 - 14 May 2021,

Conference Abstracts | 2021

Tavakoli A; Markoulli M; Flanagan J; Papas E, 2021, 'The association between the ocular discomfort and corneal dendritic cell densities', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Vol. 62,

Conference Papers | 2020

Alotaibi S; Markoulli M; Papas EB; Ozkan J, 2020, 'Telomerase in the Human Tears', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ELECTR NETWORK, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), ELECTR NETWORK, 01 May 2020 - 07 May 2020

Conference Papers | 2020

Chiang JCB; Goldstein D; Trinh T; Au K; Krishnan AV; Markoulli M, 2020, 'The relationship between the Ocular Surface Disease Index and conventional assessments of chemotherapy-induced peripheral neuropathy', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ELECTR NETWORK, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), ELECTR NETWORK, 01 May 2020 - 07 May 2020,

Conference Abstracts | 2020

Flanagan J; Huang B; Tavakoli S; Markoulli M; Papas EB, 2020, 'Is dry eye related to diet?', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ELECTR NETWORK, Vol. 61, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), ELECTR NETWORK, 01 May 2020 - 07 May 2020,

Conference Papers | 2020

Zahari I; Tummanapalli S; Colorado LH; Markoulli M; Pritchard N; Schmid KL; Efron N; Edwards K, 2020, 'Exploring novel features in the corneal nerve plexus in a healthy population: globular cells and microneuromas', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, ELECTR NETWORK, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), ELECTR NETWORK, 01 May 2020 - 07 May 2020,

Conference Abstracts | 2019

Hallett N; Maseedupally VK; Markoulli M; Jeyakumar N; Hodge C; Sutton G; You J, 2019, 'In-vivo and in-vitro corneal epithelial and stromal thickness in Keratoconus', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, CANADA, Vancouver, Vol. 60, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), CANADA, Vancouver, 28 April 2019 - 02 May 2019,

Conference Papers | 2019

Tummanapalli SS; Willcox M; Issar T; Yan A; Kwai N; Poynten A; Krishnan A; Markoulli M, 2019, 'Reduced tear film substance P concentration is associated with diabetic peripheral neuropathy', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, CANADA, Vancouver, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), CANADA, Vancouver, 28 April 2019 - 02 May 2019,

Conference Papers | 2018

Markoulli M; Colorado LH; Edwards K, 2018, 'Corneal nerve morphology and its association with inflammatory mediators and neuropeptides in the healthy tear film', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, HI, Honolulu, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), HI, Honolulu, 29 April 2018 - 03 May 2018,

Conference Papers | 2018

Markoulli M; Sengmany K; Xie K; Dutta D, 2018, 'Corneal nerve morphology and dry eye people with diabetes.', in Corneal nerve morphology and dry eye people with diabetes., American Academy of Optometry, San Antonio, USA, presented at American Academy of Optometry, San Antonio, USA, 07 November 2018 - 10 August 2018

Conference Papers | 2018

Tummanapalli SS; Issar T; Kwai N; Poyten A; Krishnan A; Willcox MDP; Markoulli M, 2018, 'Assessment of corneal nerve structure and peripheral nerve function in detection of diabetic peripheral neuropathy', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, HI, Honolulu, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), HI, Honolulu, 29 April 2018 - 03 May 2018,

Conference Abstracts | 2018

Yeotikar NS; Flanagan J; Naduvilath TJ; Markoulli M; Tilia D; Papas EB, 2018, 'Association between meibomian lipid profiles and age-related changes in gland morphology and function', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, HI, Honolulu, Vol. 59, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), HI, Honolulu, 29 April 2018 - 03 May 2018,

Conference Abstracts | 2017

Flanagan J; Yeotikar N; Zhu H; Markoulli M; Papas EB, 2017, 'Ocular bacterial burden and dry eye symptoms in a normal population', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, MD, Baltimore, Vol. 58, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO) - Imaging in the Eye, MD, Baltimore, 06 May 2017 - 11 May 2017,

Conference Abstracts | 2016

Dutta D; Sarkes M; Nath S; Markoulli M, 2016, 'Repeatability and correlation of tear ferning with lipid layer thickness, non-invasive tear break up time and OSDI.', in Repeatability and correlation of tear ferning with lipid layer thickness, non-invasive tear break up time and OSDI., Repeatability and correlation of tear ferning with lipid layer thickness, non-invasive tear break up time and OSDI., Anaheim, USA, presented at Repeatability and correlation of tear ferning with lipid layer thickness, non-invasive tear break up time and OSDI., Anaheim, USA, 09 November 2016 - 12 November 2016

Conference Papers | 2016

Markoulli M; Lum E; You J; Duong C; Tolentino J; Kim J, 2016, 'CORNEAL NERVE MORPHOLOGY AND TEAR FILM SUBSTANCE P IN DIABETES', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, WA, Seattle, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), WA, Seattle, 01 May 2016 - 05 May 2016,

Conference Abstracts | 2016

Stapleton F; Chao C; Jalbert I; Mandathara P; Kolanu S; Willcox M; Markoulli M; You JJ; Kim J; Lum E; Golebiowski B, 2016, 'Relationships between central corneal nerve parameters and tear neuropeptides', in Invest Ophthalmol Vis Sci, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, Seattle, WA, Vol. 57, pp. E - abstract 2796, presented at ARVO Annual Meeting, Seattle, WA, 01 May 2016 - 05 May 2016,

Conference Papers | 2016

Stapleton F; Chao C; Jalbert I; Mandathara P; Kolanu S; Willcox M; Markoulli M; You JJ; Kim J; Lum E; Golebiowski B, 2016, 'Relationships between central corneal nerve parameters and tear neuropeptides', in Relationships between central corneal nerve parameters and tear neuropeptides, Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA, presented at Annual Meeting of the Association for Research in Vision and Ophthalmology (ARVO), Seattle, WA, 01 May 2016 - 05 May 2016

Conference Abstracts | 2015

Alghamdi W; Markoulli M; Holden BA; Papas EB, 2015, 'Potential Role for Matrix Metalloproteinase-9 in Meibomian Gland Changes in Contact Lens Wearers', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC, CO, Denver, Vol. 56, presented at Annual Meeting of the Association-for-Research-in-Vision-and-Ophthalmology (ARVO), CO, Denver, 03 May 2015 - 07 May 2015,

Conference Papers | 2014

Alghamdi W; Markoulli M; Holden BA; Papas EB, 2014, 'Impact of Current and Previous Contact Lens Wear on Meibomian Glands and Tear Film Characteristics.', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,

Conference Papers | 2014

Yeotikar NS; Zhu H; Omali NB; Tilia D; Thomas V; Markoulli M; Nichols KK; Nichols JJ; Papas EB, 2014, 'The natural history of meibomian glands: Age-related changes in an asymptomatic population', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,

Conference Papers | 2010

Markoulli M; Papas E; Holden BA, 2010, 'Diurnal Variation of MMP-9 in the Tear Film', in INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, ASSOC RESEARCH VISION OPHTHALMOLOGY INC,

My research program exploits the accessibility of the tear film and the transparency of the cornea to research ways to better characterise, diagnose and monitor ocular and systemic diseases. Specifically, my research program aims to:��

understand the impact that systemic diseases such as diabetes, impaired glucose tolerance, chronic kidney disease and treatment with chemotherapy have on corneal nerves and tear film biochemistry, and to use these findings to produce improved diagnostic markers that will help monitor progression of disease and the effect of therapy.
characterise the impact of contact lenses, dry eye disease and meibomian gland dysfunction on the ocular surface and identify effective treatments to minimise these changes.

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