Dr Robert Weatheritt

Senior Research Fellow

PhD

Science

School of Biotech & Biomolecular Science

Associate Professor Robert Weatheritt is an ARC Future Fellow, an EMBL Australia Group Leader at BABS in UNSW Sydney and a Lab Head at the Garvan Institute. Dr. Weatheritt received his PhD from EMBL Heidelberg and then proceeded to undertaken a Postdoctoral fellow at the University of Cambridge and the University of Toronto. Dr. Weatheritt opened his lab in 2018 focusing on combining data data approaches with CRISPR screening approaches and transcriptomics to understand the role of RNA in driving cellular phenotypes. Dr. Weatheritt has published over 40 peer-reviewed articles in high-impact journals including multiple papers in Nature, Cell and Science.��

E-mail

r.weatheritt@garvan.org.au

Location

School of Biotechnology and Biomolecular Sciences

Journal articles | 2024

Kjer-Hansen P; Phan TG; Weatheritt RJ, 2024, 'Protein isoform-centric therapeutics: expanding targets and increasing specificity', Nature Reviews Drug Discovery, 23, pp. 759 - 779,

Journal articles | 2024

Xiao MS; Damodaran AP; Kumari B; Dickson E; Xing K; On TA; Parab N; King HE; Perez AR; Guiblet WM; Duncan G; Che A; Chari R; Andresson T; Vidigal JA; Weatheritt RJ; Aregger M; Gonatopoulos-Pournatzis T, 2024, 'Genome-scale exon perturbation screens uncover exons critical for cell fitness', Molecular Cell, 84, pp. 2553 - 2572.e19,

Journal articles | 2023

Guerra M; Medici V; Weatheritt R; Corvino V; Palacios D; Geloso MC; Farini D; Sette C, 2023, 'Fetal exposure to valproic acid dysregulates the expression of autism-linked genes in the developing cerebellum', Translational Psychiatry, 13,

Journal articles | 2023

Kjer-Hansen P; Weatheritt RJ, 2023, 'The function of alternative splicing in the proteome: rewiring protein interactomes to put old functions into new contexts', Nature Structural and Molecular Biology, 30, pp. 1844 - 1856,

Journal articles | 2023

Roth JF; Braunschweig U; Wu M; Li JD; Lin ZY; Larsen B; Weatheritt RJ; Gingras AC; Blencowe BJ, 2023, 'Systematic analysis of alternative exon-dependent interactome remodeling reveals multitasking functions of gene regulatory factors', Molecular Cell, 83, pp. 4222 - 4238.e10,

Journal articles | 2023

Sinitcyn P; Richards AL; Weatheritt RJ; Brademan DR; Marx H; Shishkova E; Meyer JG; Hebert AS; Westphall MS; Blencowe BJ; Cox J; Coon JJ, 2023, 'Global detection of human variants and isoforms by deep proteome sequencing', Nature Biotechnology, 41, pp. 1776 - 1786,

Journal articles | 2022

Bartonicek N; Rouet R; Warren J; Loetsch C; Rodriguez GS; Walters S; Lin F; Zahra D; Blackburn J; Hammond JM; Reis ALM; Deveson IW; Zammit N; Zeraati M; Grey S; Christ D; Mattick JS; Chtanova T; Brink R; Dinger ME; Weatheritt RJ; Sprent J; King C, 2022, 'The retroelement Lx9 puts a brake on the immune response to virus infection', Nature, 608, pp. 757 - 765,

Journal articles | 2022

Barutcu AR; Wu M; Braunschweig U; Dyakov BJA; Luo Z; Turner KM; Durbic T; Lin ZY; Weatheritt RJ; Maass PG; Gingras AC; Blencowe BJ, 2022, 'Systematic mapping of nuclear domain-associated transcripts reveals speckles and lamina as hubs of functionally distinct retained introns', Molecular Cell, 82, pp. 1035 - 1052.e9,

Journal articles | 2022

Bournazos AM; Riley LG; Bommireddipalli S; Ades L; Akesson LS; Al-Shinnag M; Alexander SI; Archibald AD; Balasubramaniam S; Berman Y; Beshay V; Boggs K; Bojadzieva J; Brown NJ; Bryen SJ; Buckley MF; Chong B; Davis MR; Dawes R; Delatycki M; Donaldson L; Downie L; Edwards C; Edwards M; Engel A; Ewans LJ; Faiz F; Fennell A; Field M; Freckmann ML; Gallacher L; Gear R; Goel H; Goh S; Goodwin L; Hanna B; Harraway J; Higgins M; Ho G; Hopper BK; Horton AE; Hunter MF; Huq AJ; Josephi-Taylor S; Joshi H; Kirk E; Krzesinski E; Kumar KR; Lemckert F; Leventer RJ; Lindsey-Temple SE; Lunke S; Ma A; Macaskill S; Mallawaarachchi A; Marty M; Marum JE; McCarthy HJ; Menezes MP; McLean A; Milnes D; Mohammad S; Mowat D; Niaz A; Palmer EE; Patel C; Patel SG; Phelan D; Pinner JR; Rajagopalan S; Regan M; Rodgers J; Rodrigues M; Roxburgh RH; Sachdev R; Roscioli T; Samarasekera R; Sandaradura SA; Savva E; Schindler T; Shah M; Sinnerbrink IB; Smith JM; Smith RJ; Springer A; Stark Z; Strom SP; Sue CM; Tan K; Tan TY; Tantsis E; Tchan MC; Thompson BA; Trainer AH; van Spaendonck-Zwarts K; Walsh R; Warwick L; White S; White SM; Williams MG, 2022, 'Standardized practices for RNA diagnostics using clinically accessible specimens reclassifies 75% of putative splicing variants', Genetics in Medicine, 24, pp. 130 - 145,

Journal articles | 2022

Han H; Best AJ; Braunschweig U; Mikolajewicz N; Li JD; Roth J; Chowdhury F; Mantica F; Nabeel-Shah S; Parada G; Brown KR; O'Hanlon D; Wei J; Yao Y; Zid AA; Comsa LC; Jen M; Wang J; Datti A; Gonatopoulos-Pournatzis T; Weatheritt RJ; Greenblatt JF; Wrana JL; Irimia M; Gingras AC; Moffat J; Blencowe BJ, 2022, 'Systematic exploration of dynamic splicing networks reveals conserved multistage regulators of neurogenesis', Molecular Cell, 82, pp. 2982 - 2999.e14,

Journal articles | 2022

Skvortsova K; Bertrand S; Voronov D; Duckett PE; Ross SE; Magri MS; Maeso I; Weatheritt RJ; Gómez Skarmeta JL; Arnone MI; Escriva H; Bogdanovic O, 2022, 'Active DNA demethylation of developmental cis-regulatory regions predates vertebrate origins', Science Advances, 8,

Journal articles | 2022

Wang J; Weatheritt R; Voineagu I, 2022, 'Alu-minating the Mechanisms Underlying Primate Cortex Evolution', Biological Psychiatry, 92, pp. 760 - 771,

Journal articles | 2021

Ha KCH; Sterne-Weiler T; Morris Q; Weatheritt RJ; Blencowe BJ, 2021, 'Differential contribution of transcriptomic regulatory layers in the definition of neuronal identity', Nature Communications, 12,

Journal articles | 2021

Santos-Rodriguez G; Voineagu I; Weatheritt RJ, 2021, 'Evolutionary dynamics of circular RNAs in primates', ,

Journal articles | 2021

Santos-Rodriguez G; Voineagu I; Weatheritt RJ, 2021, 'Evolutionary dynamics of circular rnas in primates', eLife, 10,

Journal articles | 2020

Farini D; Cesari E; Weatheritt RJ; La Sala G; Naro C; Pagliarini V; Bonvissuto D; Medici V; Guerra M; Di Pietro C; Rizzo FR; Musella A; Carola V; Centonze D; Blencowe BJ; Marazziti D; Sette C, 2020, 'A Dynamic Splicing Program Ensures Proper Synaptic Connections in the Developing Cerebellum', Cell Reports, 31,

Journal articles | 2020

Gonatopoulos-Pournatzis T; Niibori R; Salter EW; Weatheritt RJ; Tsang B; Farhangmehr S; Liang X; Braunschweig U; Roth J; Zhang S; Henderson T; Sharma E; Quesnel-Vallières M; Permanyer J; Maier S; Georgiou J; Irimia M; Sonenberg N; Forman-Kay JD; Gingras AC; Collingridge GL; Woodin MA; Cordes SP; Blencowe BJ, 2020, 'Autism-Misregulated eIF4G Microexons Control Synaptic Translation and Higher Order Cognitive Functions', Molecular Cell, 77, pp. 1176 - 1192.e16,

Journal articles | 2020

Luck K; Kim DK; Lambourne L; Spirohn K; Begg BE; Bian W; Brignall R; Cafarelli T; Campos-Laborie FJ; Charloteaux B; Choi D; Coté AG; Daley M; Deimling S; Desbuleux A; Dricot A; Gebbia M; Hardy MF; Kishore N; Knapp JJ; Kovács IA; Lemmens I; Mee MW; Mellor JC; Pollis C; Pons C; Richardson AD; Schlabach S; Teeking B; Yadav A; Babor M; Balcha D; Basha O; Bowman-Colin C; Chin SF; Choi SG; Colabella C; Coppin G; D’Amata C; De Ridder D; De Rouck S; Duran-Frigola M; Ennajdaoui H; Goebels F; Goehring L; Gopal A; Haddad G; Hatchi E; Helmy M; Jacob Y; Kassa Y; Landini S; Li R; van Lieshout N; MacWilliams A; Markey D; Paulson JN; Rangarajan S; Rasla J; Rayhan A; Rolland T; San-Miguel A; Shen Y; Sheykhkarimli D; Sheynkman GM; Simonovsky E; Taşan M; Tejeda A; Tropepe V; Twizere JC; Wang Y; Weatheritt RJ; Weile J; Xia Y; Yang X; Yeger-Lotem E; Zhong Q; Aloy P; Bader GD; De Las Rivas J; Gaudet S; Hao T; Rak J; Tavernier J; Hill DE; Vidal M; Roth FP; Calderwood MA, 2020, 'A reference map of the human binary protein interactome', Nature, 580, pp. 402 - 408,

Journal articles | 2020

Rodrigues DC; Mufteev M; Weatheritt RJ; Djuric U; Ha KCH; Ross PJ; Wei W; Piekna A; Sartori MA; Byres L; Mok RSF; Zaslavsky K; Pasceri P; Diamandis P; Morris Q; Blencowe BJ; Ellis J, 2020, 'Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome', Cell Reports, 30, pp. 4179 - 4196.e11,

Journal articles | 2019

Avgan N; Wang JI; Fernandez-Chamorro J; Weatheritt RJ, 2019, 'Multilayered control of exon acquisition permits the emergence of novel forms of regulatory control', Breast Cancer Research, 21,

Journal articles | 2019

Quesnel-Vallières M; Weatheritt RJ; Cordes SP; Blencowe BJ, 2019, 'Autism spectrum disorder: insights into convergent mechanisms from transcriptomics', Nature Reviews Genetics, 20, pp. 51 - 63,

Journal articles | 2018

Sterne-Weiler T; Weatheritt RJ; Best AJ; Ha KCH; Blencowe BJ, 2018, 'Efficient and Accurate Quantitative Profiling of Alternative Splicing Patterns of Any Complexity on a Laptop', Molecular Cell, 72, pp. 187 - 200.e6,

Journal articles | 2017

Gueroussov S; Weatheritt RJ; O'Hanlon D; Lin ZY; Narula A; Gingras AC; Blencowe BJ, 2017, 'Regulatory Expansion in Mammals of Multivalent hnRNP Assemblies that Globally Control Alternative Splicing', Cell, 170, pp. 324 - 339.e23,

Journal articles | 2017

Han H; Braunschweig U; Gonatopoulos-Pournatzis T; Weatheritt RJ; Hirsch CL; Ha KCH; Radovani E; Nabeel-Shah S; Sterne-Weiler T; Wang J; O'Hanlon D; Pan Q; Ray D; Zheng H; Vizeacoumar F; Datti A; Magomedova L; Cummins CL; Hughes TR; Greenblatt JF; Wrana JL; Moffat J; Blencowe BJ, 2017, 'Multilayered Control of Alternative Splicing Regulatory Networks by Transcription Factors', Molecular Cell, 65, pp. 539 - 553.e7,

Journal articles | 2017

Sterne-Weiler T; Weatheritt R; Best A; Ha K; Blencowe B, 2017, 'Whippet: an efficient method for the detection and quantification of alternative splicing reveals extensive transcriptomic complexity', ,

Journal articles | 2016

Dominguez D; Tsai YH; Weatheritt R; Wang Y; Blencowe BJ; Wang Z, 2016, 'An extensive program of periodic alternative splicing linked to cell cycle progression', eLife, 5,

Journal articles | 2016

Latysheva NS; Oates ME; Maddox L; Flock T; Gough J; Buljan M; Weatheritt RJ; Babu MM, 2016, 'Molecular Principles of Gene Fusion Mediated Rewiring of Protein Interaction Networks in Cancer', Molecular Cell, 63, pp. 579 - 592,

Journal articles | 2016

Weatheritt RJ; Sterne-Weiler T; Blencowe BJ, 2016, 'The ribosome-engaged landscape of alternative splicing', Nature Structural and Molecular Biology, 23, pp. 1117 - 1123,

Journal articles | 2015

Latysheva NS; Flock T; Weatheritt RJ; Chavali S; Babu MM, 2015, 'How do disordered regions achieve comparable functions to structured domains?', Protein Science, 24, pp. 909 - 922,

Journal articles | 2014

Davey NE; Van Roey K; Weatheritt RJ; Toedt G; Uyar B; Altenberg B; Budd A; Diella F; Dinkel H; Gibson TJ, 2014, 'Erratum: Attributes of short linear motifs (Molecular BioSystems (2012) 8 (268-281) DOI: 10.1039/C1MB05231D)', Molecular BioSystems, 10, pp. 2481,

Journal articles | 2014

Dinkel H; Van Roey K; Michael S; Davey NE; Weatheritt RJ; Born D; Speck T; Krüger D; Grebnev G; Kubań M; Strumillo M; Uyar B; Budd A; Altenberg B; Seiler M; Chemes LB; Glavina J; Sánchez IE; Diella F; Gibson TJ, 2014, 'The eukaryotic linear motif resource ELM: 10 years and counting', Nucleic Acids Research, 42,

Journal articles | 2014

Flock T; Weatheritt RJ; Latysheva NS; Babu MM, 2014, 'Controlling entropy to tune the functions of intrinsically disordered regions', Current Opinion in Structural Biology, 26, pp. 62 - 72,

Journal articles | 2014

Irimia M; Weatheritt RJ; Ellis JD; Parikshak NN; Gonatopoulos-Pournatzis T; Babor M; Quesnel-Vallières M; Tapial J; Raj B; O'Hanlon D; Barrios-Rodiles M; Sternberg MJE; Cordes SP; Roth FP; Wrana JL; Geschwind DH; Blencowe BJ, 2014, 'A highly conserved program of neuronal microexons is misregulated in autistic brains', Cell, 159, pp. 1511 - 1523,

Journal articles | 2014

Uyar B; Weatheritt RJ; Dinkel H; Davey NE; Gibson TJ, 2014, 'Proteome-wide analysis of human disease mutations in short linear motifs: Neglected players in cancer?', Molecular BioSystems, 10, pp. 2626 - 2642,

Journal articles | 2014

Van Der Lee R; Buljan M; Lang B; Weatheritt RJ; Daughdrill GW; Dunker AK; Fuxreiter M; Gough J; Gsponer J; Jones DT; Kim PM; Kriwacki RW; Oldfield CJ; Pappu RV; Tompa P; Uversky VN; Wright PE; Babu MM, 2014, 'Classification of intrinsically disordered regions and proteins', Chemical Reviews, 114, pp. 6589 - 6631,

Journal articles | 2014

Van Roey K; Uyar B; Weatheritt RJ; Dinkel H; Seiler M; Budd A; Gibson TJ; Davey NE, 2014, 'Short linear motifs: Ubiquitous and functionally diverse protein interaction modules directing cell regulation', Chemical Reviews, 114, pp. 6733 - 6778,

Journal articles | 2014

Weatheritt RJ; Gibson TJ; Babu MM, 2014, 'Asymmetric mRNA localization contributes to fidelity and sensitivity of spatially localized systems', Nature Structural and Molecular Biology, 21, pp. 833 - 839,

Journal articles | 2013

Reyes A; Anders S; Weatheritt RJ; Gibson TJ; Steinmetz LM; Huber W, 2013, 'Drift and conservation of differential exon usage across tissues in primate species', Proceedings of the National Academy of Sciences of the United States of America, 110, pp. 15377 - 15382,

Journal articles | 2013

Van Roey K; Dinkel H; Weatheritt RJ; Gibson TJ; Davey NE, 2013, 'The switches.ELM resource: A compendium of conditional regulatory interaction interfaces', Science Signaling, 6,

Journal articles | 2013

Weatheritt RJ; Babu MM, 2013, 'The hidden codes that shape protein evolution', Science, 342, pp. 1325 - 1326,

Journal articles | 2012

Davey NE; Van Roey K; Weatheritt RJ; Toedt G; Uyar B; Altenberg B; Budd A; Diella F; Dinkel H; Gibson TJ, 2012, 'Attributes of short linear motifs', Molecular BioSystems, 8, pp. 268 - 281,

Journal articles | 2012

Dinkel H; Michael S; Weatheritt RJ; Davey NE; Van Roey K; Altenberg B; Toedt G; Uyar B; Seiler M; Budd A; Jödicke L; Dammert MA; Schroeter C; Hammer M; Schmidt T; Jehl P; McGuigan C; Dymecka M; Chica C; Luck K; Via A; Chatr-Aryamontri A; Haslam N; Grebnev G; Edwards RJ; Steinmetz MO; Meiselbach H; Diella F; Gibson TJ, 2012, 'ELM - The database of eukaryotic linear motifs', Nucleic Acids Research, 40,

Journal articles | 2012

Weatheritt RJ; Davey NE; Gibson TJ, 2012, 'Linear motifs confer functional diversity onto splice variants', Nucleic Acids Research, 40, pp. 7123 - 7131,

Journal articles | 2012

Weatheritt RJ; Gibson TJ, 2012, 'Linear motifs: Lost in (pre)translation', Trends in Biochemical Sciences, 37, pp. 333 - 341,

Journal articles | 2012

Weatheritt RJ; Jehl P; Dinkel H; Gibson TJ, 2012, 'iELM-a web server to explore short linear motif-mediated interactions', Nucleic Acids Research, 40, pp. w364 - w369,

Journal articles | 2012

Weatheritt RJ; Luck K; Petsalaki E; Davey NE; Gibson TJ, 2012, 'The identification of short linear motif-mediated interfaces within the human interactome', Bioinformatics, 28, pp. 976 - 982,

Journal articles | 2009

Gould CM; Diella F; Via A; Puntervoll P; Gemünd C; Chabanis-Davidson S; Michael S; Sayadi A; Bryne JC; Chica C; Seiler M; Davey NE; Haslam N; Weatheritt RJ; Budd A; Hughes T; Paś J; Rychlewski L; Travé G; Aasland R; Helmer-Citterich M; Linding R; Gibson TJ, 2009, 'ELM: The status of the 2010 eukaryotic linear motif resource', Nucleic Acids Research, 38,

Journal articles | 2009

Krumbholz K; Nobis EA; Weatheritt RJ; Fink GR, 2009, 'Executive control of spatial attention shifts in the auditory compared to the visual modality', Human Brain Mapping, 30, pp. 1457 - 1469,

Journal articles | 2009

Yanashima R; Kitagawa N; Matsubara Y; Weatheritt R; Oka K; Kikuchi S; Tomita M; Ishizaki S, 2009, 'Network Features and Pathway Analyses of a Signal Transduction Cascade.', Front Neuroinform, 3, pp. 13,

Journal articles | 2009

Yanashima R; Kitagawa N; Matsubara Y; Weatheritt R; Oka K; Kikuchi S; Tomita M; Ishizaki S, 2009, 'Network features and pathway analyses of a signal transduction cascade', Frontiers in Neuroinformatics, 3,
Preprints | 2024

Santos-Rodriguez G; Srivastava A; Ravindran A; Oyelami F; Ip KH; Gupta P; Villanueva J; King HE; Grootveld A; Blackburn J; Gupta I; Vieira HGS; Shirokikh NE; Eyras E; Weatheritt RJ, 2024, The conserved landscape of RNA modifications and transcript diversity across mammalian evolution,

Preprints | 2021

Skvortsova K; Bertrand S; Voronov D; Duckett PE; Ross SE; Magri MS; Maeso I; Weatheritt RJ; Gomez-Skarmeta JL; Arnone MI; Escriva H; Bogdanovic O, 2021, Active DNA demethylation of developmental cis-regulatory regions predates vertebrate origins,

Preprints | 2019

Luck K; Kim D-K; Lambourne L; Spirohn K; Begg BE; Bian W; Brignall R; Cafarelli T; Campos-Laborie FJ; Charloteaux B; Choi D; Cote AG; Daley M; Deimling S; Desbuleux A; Dricot A; Gebbia M; Hardy MF; Kishore N; Knapp JJ; Kovács IA; Lemmens I; Mee MW; Mellor JC; Pollis C; Pons C; Richardson AD; Schlabach S; Teeking B; Yadav A; Babor M; Balcha D; Basha O; Bowman-Colin C; Chin S-F; Choi SG; Colabella C; Coppin G; D’Amata C; De Ridder D; De Rouck S; Duran-Frigola M; Ennajdaoui H; Goebels F; Goehring L; Gopal A; Haddad G; Hatchi E; Helmy M; Jacob Y; Kassa Y; Landini S; Li R; van Lieshout N; MacWilliams A; Markey D; Paulson JN; Rangarajan S; Rasla J; Rayhan A; Rolland T; San-Miguel A; Shen Y; Sheykhkarimli D; Sheynkman GM; Simonovsky E; Taşan M; Tejeda A; Twizere J-C; Wang Y; Weatheritt RJ; Weile J; Xia Y; Yang X; Yeger-Lotem E; Zhong Q; Aloy P; Bader GD; De Las Rivas J; Gaudet S; Hao T; Rak J; Tavernier J; Tropepe V; Hill DE; Vidal M; Roth FP; Calderwood MA, 2019, A reference map of the human protein interactome,

Datasets | 2017

Babu MM; Weatheritt R, 2017, Faculty Opinions recommendation of Membraneless organelles can melt nucleic acid duplexes and act as biomolecular filters., ,

Datasets | 2013

Babu MM; Weatheritt R, 2013, Faculty Opinions recommendation of A pH-regulated quality control cycle for surveillance of secretory protein assembly., ,

Datasets | 2013

Babu MM; Weatheritt R, 2013, Faculty Opinions recommendation of MBNL proteins repress ES-cell-specific alternative splicing and reprogramming., ,

Datasets | 2013

Babu MM; Weatheritt R, 2013, Faculty Opinions recommendation of Transcriptome-wide regulation of pre-mRNA splicing and mRNA localization by muscleblind proteins., ,

Preprints |

Rodrigues DC; Mufteev M; Weatheritt RJ; Djuric U; Ha KCH; Ross PJ; Zaslavsky K; Mok RSF; Wei W; Piekna A; Byres L; Pasceri P; Diamandis P; Morris Q; Blencowe BJ; Ellis J, Shifts in Ribosome Engagement Impact Key Gene Sets in Neurodevelopment and Ubiquitination in Rett Syndrome,

NSW Health RNA Future Leaders Program (2022-2025)
- Title: Developing in vivo CRISPR RNA engineering to prevent disease
Australian Research Council Future Fellowship (2022-2026)
- Title: Dissecting cell cycle regulation using programmable gene editing technology
NSW Cancer Council Grant (2021-2024)
- Title: What makes triple-negative breast cancer tumours more likely to spread beyond the breast?��
NSW Cancer Institute Fellowship (2021-2024)
- P-bodies: a novel mechanism driving triple negative breast cancer?
ARC Discovery Project Grant (2020-2023) with Irinia Voineagu (UNSW Sydney)
- Title: Investigating the biogenesis and function of circular RNAs in the brain

Alternative splicing, Intrinsically disordered regions, Post-transcriptional regulation, Neuroscience, Autism-spectrum disorder, RNA, Proteomics, Structural Bioinformatics, RNA-Seq

My Research Supervision

Peter Kjer Hansen

Helen King

Daisy Kavanagh

My Teaching

I convene the 3rd year course BABS3291 Genes, Genomes and Evolution

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