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Professor Till Boecking

Professor Till Boecking

Professor
Medicine & Health
School of Biomedical Sciences

Till Böcking leads the Molecular Machines Group in the EMBL Australia Node for Single Molecule Science. Originally trained in biochemistry at the University of Bonn in Germany, he crossed disciplines and completed a PhD in Biophysics at UNSW with Hans Coster and Kevin Barrow in 2004. During his doctoral and subsequent postdoctoral research with Justin Gooding and Michael Gal, he developed self-assembly chemistries to assemble biomolecules on surfaces. This work lead to the development of biosensors and the discovery of fundamental principles that govern the performance of these devices. In 2006 he joined the group of Tomas Kirchhausen at Harvard Medical School to elucidate the mechanism of the chaperone-mediated disassembly of the protein coat surrounding endocytic vesicles. Till was awarded a Cross-Disciplinary Fellowship of the Human Frontier Science Program in 2007. Since returning to Australia, Till leads independent research focused on understanding biological processes at the molecular level using approaches from the physical sciences. In particular his team uses single-molecule techniques to resolve mechanistsic questions inaccessible with traditional approaches. 

Phone
+61 2 9385 1179
Location
Lowy Cancer Centre Building, Level 3
  • Book Chapters | 2018
    Böcking T; Upadhyayula S; Rapoport I; Capraro BR; Kirchhausen T, 2018, 'Reconstitution of clathrin coat disassembly for fluorescence microscopy and single-molecule analysis', in Clathrin-Mediated Endocytosis. Methods in Molecular Biology, Humana Press, New York, NY, pp. 121 - 146,
    Book Chapters | 2007
    Boecking T; Gooding JJ, 2007, 'Biomimetic Membranes for Biosensor Applications', in Martin DK (ed.), Nanobiotechnology for Biomimetic Membranes, Springer Publishing Company, USA, pp. 127 - 166
  • Journal articles | 2024
    Dickson CF; Hertel S; Tuckwell AJ; Li N; Ruan J; Al-Izzi SC; Ariotti N; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, 2024, 'The HIV capsid mimics karyopherin engagement of FG-nucleoporins', Nature, 626, pp. 836 - 842,
    Journal articles | 2024
    Faysal KMR; Walsh JC; Renner N; Márquez CL; Shah VB; Tuckwell AJ; Christie MP; Parker MW; Turville SG; Towers GJ; James LC; Jacques DA; Böcking T, 2024, 'Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure', eLife, 13,
    Journal articles | 2023
    Renner N; Kleinpeter A; Mallery DL; Albecka A; Rifat Faysal KM; Böcking T; Saiardi A; Freed EO; James LC, 2023, 'HIV-1 is dependent on its immature lattice to recruit IP6 for mature capsid assembly', Nature Structural and Molecular Biology, 30, pp. 370 - 382,
    Journal articles | 2022
    Brown JWP; Alford RG; Walsh JC; Spinney RE; Xu SY; Hertel S; Berengut JF; Spenkelink LM; Van Oijen AM; Böcking T; Morris RG; Lee LK, 2022, 'Rapid Exchange of Stably Bound Protein and DNA Cargo on a DNA Origami Receptor', ACS Nano, 16, pp. 6455 - 6467,
    Journal articles | 2022
    Guinness CM; Walsh JC; Bayly-Jones C; Dunstone MA; Christie MP; Morton CJ; Parker MW; Bocking T, 2022, 'Single-molecule analysis of the entire perfringolysin O pore formation pathway', eLife, 11,
    Journal articles | 2022
    Johnstone BA; Joseph R; Christie MP; Morton CJ; McGuiness C; Walsh JC; Böcking T; Tweten RK; Parker MW, 2022, 'Cholesterol-dependent cytolysins: The outstanding questions', IUBMB Life, 74, pp. 1169 - 1179,
    Journal articles | 2022
    Lau D; Márquez CL; Parker MW; Böcking T, 2022, 'Negative Staining Transmission Electron Microscopy of HIV Viral Particles Permeabilized with PFO and Capsid Stabilized with IP6', Bio-protocol, 12,
    Journal articles | 2022
    Longatte G; Lisi F; Bakthavathsalam P; Böcking T; Gaus K; Tilley RD; Gooding JJ, 2022, 'Biomolecular Binding under Confinement: Statistical Predictions of Steric Influence in Absence of Long-Distance Interactions', ChemPhysChem, 23, pp. e202100765,
    Journal articles | 2022
    Longatte G; Lisi F; Chen X; Walsh J; Wang W; Ariotti N; Boecking T; Gaus K; Gooding JJ, 2022, 'Statistical predictions on the encapsulation of single molecule binding pairs into sized-dispersed nanocontainers', Physical Chemistry Chemical Physics, 24, pp. 28029 - 28039,
    Journal articles | 2022
    Yoh SM; Mamede JI; Lau D; Ahn N; Sánchez-Aparicio MT; Temple J; Tuckwell A; Fuchs NV; Cianci GC; Riva L; Curry H; Yin X; Gambut S; Simons LM; Hultquist JF; König R; Xiong Y; García-Sastre A; Böcking T; Hope TJ; Chanda SK, 2022, 'Recognition of HIV-1 capsid by PQBP1 licenses an innate immune sensing of nascent HIV-1 DNA', Molecular Cell, 82, pp. 2871 - 2884.e6,
    Journal articles | 2022
    Zhang MJ; Stear JH; Jacques DA; Böcking T, 2022, 'Insights into HIV uncoating from single-particle imaging techniques', Biophysical Reviews, 14, pp. 23 - 32,
    Journal articles | 2022
    Zuliani-Alvarez L; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Rifat Faysal KM; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, 2022, 'Evasion of cGAS and TRIM5 defines pandemic HIV', Nature Microbiology, 7, pp. 1762 - 1776,
    Journal articles | 2021
    Böcking T; Jacques DA; Lau D; Walsh JC; Dickson CF; Tuckwell A; Stear JH; Hunter DJB; Bhumkar A; Shah V; Turville SG; Sierecki E; Gambin Y, 2021, 'Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy', Analytical Chemistry, 93, pp. 3786 - 3793,
    Journal articles | 2021
    Mallery DL; Kleinpeter AB; Renner N; Rifat Faysal KM; Novikova M; Kiss L; Wilson MSC; Ahsan B; Ke Z; Briggs JAG; Saiardi A; Böcking T; Freed EO; James LC; Faysal KMR, 2021, 'A stable immature lattice packages IP6 for HIV capsid maturation', Science Advances, 7, pp. 1 - 18,
    Journal articles | 2021
    Ni T; Zhu Y; Yang Z; Xu C; Chaban Y; Nesterova T; Ning J; Böcking T; Parker MW; Monnie C; Ahn J; Perilla JR; Zhang P, 2021, 'Structure of native HIV-1 cores and their interactions with IP6 and CypA', Science Advances, 7,
    Journal articles | 2021
    Renner N; Mallery DL; Faysal KMR; Peng W; Jacques DA; Böcking T; James LC, 2021, 'A lysine ring in HIV capsid pores coordinates IP6 to drive mature capsid assembly', PLoS Pathogens, 17, pp. 1 - 22,
    Journal articles | 2020
    Bareja I; Wioland H; Janco M; Nicovich PR; Jégou A; Romet-Lemonne G; Walsh J; Böcking T, 2020, 'Dynamics of Tpm1.8 domains on actin filaments with single-molecule resolution', Molecular Biology of the Cell, 31, pp. 2452 - 2462,
    Journal articles | 2020
    Helbig KJ; Bull RA; Ambrose R; Beard MR; Blanchard H; Böcking T; Chua B; Colmant AMG; Crosse KM; Purcell DFJ; Fraser J; Hayward JA; Hamilton ST; Husain M; MacDiarmid R; MacKenzie JM; Moseley GW; Nguyen THO; Quiñones-Mateu ME; Robinson K; Rodrigo C; Rodriguez-Andres J; Rudd PA; Werno A; White P; Young P; Speck P; Hibma M; Drummer HE; Tachedjian G, 2020, 'Tenth scientific biennial meeting of the australasian virology society - AVS10 2019', Viruses, 12, pp. 621,
    Journal articles | 2020
    Lau D; Walsh JC; Mousapasandi A; Ariotti N; Shah VB; Turville S; Jacques DA; Böcking T, 2020, 'Self-Assembly of Fluorescent HIV Capsid Spheres for Detection of Capsid Binders', Langmuir, 36, pp. 3624 - 3632,
    Journal articles | 2019
    Battle AR; Norton RS; Böcking T; Noji H; Kim KK; Nagayama K, 2019, 'Editorial: Special issue of Biophysical Reviews dedicated to the joint 10th Asian Biophysics Association Symposium and 42nd Australian Society for Biophysics Meeting, Melbourne, Australia, December 2–6, 2018', Biophysical Reviews,
    Journal articles | 2019
    James LC; Böcking T, 2019, 'Building Complexity: Making and Breaking Synthetic Subunits of the HIV Capsid', Cell Host and Microbe, 26, pp. 151 - 153,
    Journal articles | 2019
    Janco M; Rynkiewicz MJ; Li L; Hook J; Eiffe E; Ghosh A; Böcking T; Lehman WJ; Hardeman EC; Gunning PW, 2019, 'Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1', Scientific reports, 9, pp. 11262,
    Journal articles | 2019
    Lau D; Walsh J; Peng W; Shah V; Turville S; Jacques D; Böcking T, 2019, 'Fluorescence biosensor for real-time interaction dynamics of host proteins with HIV-1 capsid tubes', ,
    Journal articles | 2019
    Lau D; Walsh JC; Peng W; Shah VB; Turville S; Jacques DA; Böcking T, 2019, 'Fluorescence Biosensor for Real-Time Interaction Dynamics of Host Proteins with HIV-1 Capsid Tubes', ACS Applied Materials and Interfaces, 11, pp. 34586 - 34594,
    Journal articles | 2019
    Mallery DL; Faysal KMR; Kleinpeter A; Wilson MSC; Vaysburd M; Fletcher AJ; Novikova M; Böcking T; Freed EO; Saiardi A; James LC, 2019, 'Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication', Cell Reports, 29, pp. 3983 - 3996.e4,
    Journal articles | 2019
    Márquez CL; Lau D; Walsh J; Faysal KMR; Parker MW; Turville SG; Böcking T, 2019, 'Fluorescence Microscopy Assay to Measure HIV-1 Capsid Uncoating Kinetics in vitro', Bio-protocol, 9,
    Journal articles | 2019
    Peng W; Shi J; Márquez CL; Lau D; Walsh J; Faysal KMR; Byeon CH; Byeon IJL; Aiken C; Böcking T, 2019, 'Functional analysis of the secondary HIV-1 capsid binding site in the host protein cyclophilin A', Retrovirology, 16, pp. 10,
    Journal articles | 2018
    Janco M; Böcking T; He S; Coster ACF, 2018, 'Interactions of tropomyosin Tpm1.1 on a single actin filament: A method for extraction and processing of high resolution TIRF microscopy data', PLoS ONE, 13, pp. e0208586,
    Journal articles | 2018
    Mallery DL; Márquez CL; McEwan WA; Dickson CF; Jacques DA; Anandapadamanaban M; Bichel K; Towers GJ; Saiardi A; Böcking T; James LC, 2018, 'IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis', eLife, 7,
    Journal articles | 2018
    Masedunskas A; Appaduray MA; Lucas CA; Cagigas ML; Heydecker M; Holliday M; Meiring JCM; Hook J; Kee A; White M; Thomas P; Zhang Y; Adelstein RS; Meckel T; Böcking T; Weigert R; Bryce NS; Gunning PW; Hardeman EC; Lastra Cagigas M, 2018, 'Parallel assembly of actin and tropomyosin, but not myosin II, during de novo actin filament formation in live mice', Journal of Cell Science, 131, pp. jcs212654,
    Journal articles | 2018
    Márquez CL; Lau D; Walsh J; Shah V; McGuinness C; Wong A; Aggarwal A; Parker MW; Jacques DA; Turville S; Böcking T, 2018, 'Kinetics of HIV-1 capsid uncoating revealed by single-molecule analysis', eLife, 7,
    Journal articles | 2018
    Zhao M; Nicovich PR; Janco M; Deng Q; Yang Z; Ma Y; Böcking T; Gaus K; Gooding JJ, 2018, 'Ultralow- and Low-Background Surfaces for Single-Molecule Localization Microscopy of Multistep Biointerfaces for Single-Molecule Sensing', Langmuir, 34, pp. 10012 - 10018,
    Journal articles | 2017
    Nicovich PR; Walsh J; Böcking T; Gaus K, 2017, 'NicoLase - An open-source diode laser combiner, fiber launch, and sequencing controller for fluorescence microscopy', PLoS ONE, 12, pp. e0173879,
    Journal articles | 2017
    Ramdzan YM; Trubetskov MM; Ormsby AR; Newcombe EA; Sui X; Tobin MJ; Bongiovanni MN; Gras SL; Dewson G; Miller JML; Finkbeiner S; Moily NS; Niclis J; Parish CL; Purcell AW; Baker MJ; Wilce JA; Waris S; Stojanovski D; Böcking T; Ang CS; Ascher DB; Reid GE; Hatters DM, 2017, 'Huntingtin Inclusions Trigger Cellular Quiescence, Deactivate Apoptosis, and Lead to Delayed Necrosis', Cell Reports, 19, pp. 919 - 927,
    Journal articles | 2016
    Al-Zyoud WA; Hynson RMG; Ganuelas LA; Coster ACF; Duff AP; Baker MAB; Stewart AG; Giannoulatou E; Ho JWK; Gaus K; Liu D; Lee LK; Böcking T; Baker M, 2016, 'Binding of transcription factor GabR to DNA requires recognition of DNA shape at a location distinct from its cognate binding site', Nucleic Acids Research, 44, pp. 1411 - 1420,
    Journal articles | 2016
    Bonello TT; Janco M; Hook J; Byun A; Appaduray M; Dedova I; Hitchcock-DeGregori S; Hardeman EC; Stehn JR; Böcking T; Gunning PW, 2016, 'A small molecule inhibitor of tropomyosin dissociates actin binding from tropomyosin-directed regulation of actin dynamics', Scientific Reports, 6, pp. 19816,
    Journal articles | 2016
    Janco M; Bonello TT; Byun A; Coster ACF; Lebhar H; Dedova I; Gunning PW; Böcking T, 2016, 'The impact of tropomyosins on actin filament assembly is isoform specific', BioArchitecture, 6, pp. 61 - 75,
    Journal articles | 2016
    Nicovich PR; Janco M; Sobey T; Gajwani M; Obeidy P; Whan R; Gaus K; Gunning PW; Coster ACF; Böcking T, 2016, 'Effect of surface chemistry on tropomyosin binding to actin filaments on surfaces', Cytoskeleton, 73, pp. 729 - 738,
    Journal articles | 2016
    Sierecki E; Giles N; Bowden Q; Polinkovsky ME; Steinbeck J; Arrioti N; Rahman D; Bhumkar A; Nicovich PR; Ross I, 2016, 'Nanomolar oligomerization and selective co-aggregation of α-synuclein pathogenic mutants revealed by single-molecule fluorescence', ,
    Journal articles | 2015
    Pham S; Tabarin T; Garvey M; Pade C; Rossy J; Monaghan P; Hyatt A; Böcking T; Leis A; Gaus K; Mak J, 2015, 'Cryo-electron microscopy and single molecule fluorescent microscopy detect CD4 receptor induced HIV size expansion prior to cell entry', Virology, 486, pp. 121 - 133,
    Journal articles | 2015
    Polling S; Ormsby AR; Wood RJ; Lee K; Shoubridge C; Hughes JN; Thomas PQ; Griffin MDW; Hill AF; Bowden Q; Böcking T; Hatters DM, 2015, 'Polyalanine expansions drive a shift into α-helical clusters without amyloid-fibril formation', Nature Structural and Molecular Biology, 22, pp. 1008 - 1015,
    Journal articles | 2014
    Böcking T; Aguet F; Rapoport I; Banzhaf M; Yu A; Zeeh JC; Kirchhausen T, 2014, 'Key interactions for clathrin coat stability', Structure, 22, pp. 819 - 829,
    Journal articles | 2013
    Ngalim SH; Magenau A; Zhu Y; Tønnesen L; Fairjones Z; Gooding JJ; Böcking T; Gaus K, 2013, 'Creating adhesive and soluble gradients for imaging cell migration with fluorescence microscopy.', Journal of visualized experiments : JoVE,
    Journal articles | 2013
    Ngalim SHA; Magenau A; Zhu Y; Tønnesen L; Fairjones Z; Gooding JJ; Böcking T; Gaus K, 2013, 'Creating adhesive and soluble gradients for imaging cell migration with fluorescence microscopy', Journal of visualized experiments : JoVE,
    Journal articles | 2012
    Boecking T; Kilian KA; Reece PJ; Gaus K; Gal M; Gooding JJ, 2012, 'Biofunctionalization of free-standing porous silicon films for self-assembly of photonic devices', Soft Matter, 8, pp. 360 - 366,
    Journal articles | 2011
    Boecking T; Aguet F; Harrison SC; Kirchhausen T, 2011, 'Single-molecule analysis of a molecular disassemblase reveals the mechanism of Hsc70-driven clathrin uncoating', Nature Structural and Molecular Biology, 18, pp. 295 - 301,
    Journal articles | 2011
    Le saux G; Magenau AI; Boecking T; Gaus K; Gooding JJ, 2011, 'The Relative Importance of Topography and RGD Ligand Density for Endothelial Cell Adhesion', PLoS ONE, 6, pp. e21869,
    Journal articles | 2011
    Le saux G; Magenau AI; Gunaratnam K; Kilian KA; Boecking T; Gooding JJ; Gaus K, 2011, 'Spacing of Integrin Ligands Influences Signal Transduction in Endothelial Cells', Biophysical Journal, 101, pp. 764 - 773,
    Journal articles | 2010
    Boecking T; Kilian KA; Reece PJ; Gaus K; Gal M; Gooding JJ, 2010, 'Substrate independent assembly of optical structures guided by biomolecular interactions', ACS Applied Materials & Interfaces, 2, pp. 3270 - 3275,
    Journal articles | 2010
    Qiao H; Guan B; Boecking T; Gal M; Gooding JJ; Reece PJ, 2010, 'Optical properties of II-VI colloidal quantum dot doped porous silicon microcavities', Applied Physics Letters, 96, pp. 161106,
    Journal articles | 2010
    Xing Y; Boecking T; Wolf M; Grigorieff N; Kirchhausen T; Harrison SC, 2010, 'Structure of clathrin coat with bound Hsc70 and auxilin: mechanism of Hsc70-facilitated disassembly', European Molecular Biology Organization, 29, pp. 655 - 665
    Journal articles | 2009
    Kilian KA; Boecking T; Gooding JJ, 2009, 'The importance of surface chemistry in mesoporous materials: Lessons from porous silicon biosensors', Chemical Communications, pp. 630 - 640
    Journal articles | 2009
    Kilian KA; Lai LH; Magenau AI; Cartland SP; Boecking T; Di Girolamo N; Gal M; Gaus K; Gooding JJ, 2009, 'Smart tissue culture: in Situ monitoring of the activity of protease enzymes secreted from live cells using nanostructured photonic crystals', Nano Letters, 9, pp. 2021 - 2025
    Journal articles | 2008
    Boecking T; Kilian KA; Gaus K; Gooding JJ, 2008, 'Modifying Porous Silicon with Self-Assembled Monolayers for Biomedical Applications: The Influence of Surface Coverage on Stability and Biomolecule Coupling', Advanced Functional Materials, 18, pp. 3827 - 3833
    Journal articles | 2008
    Chilcott TC; Swong E; Boecking T; Coster HG, 2008, 'Electrical characterizations of biomimetic molecular layers on gold and silicon substrates', Physiological Measurement, 29, pp. S307 - S319
    Journal articles | 2008
    Chou A; Boecking T; Liu R; Singh NK; Moran GM; Gooding JJ, 2008, 'Effect of dialysis on the electrochemical properties of acid-oxidized single-walled carbon nanotubes', Journal of Physical Chemistry C, 112, pp. 14131 - 14138
    Journal articles | 2008
    Ciampi S; Boecking T; Kilian KA; Harper JB; Gooding JJ, 2008, 'Click chemistry in mesoporous materials: Functionalization of porous silicon rugate filters', Langmuir, 24, pp. 5888 - 5892
    Journal articles | 2008
    Kilian KA; Boecking T; Gaus K; Gooding JJ, 2008, 'Introducing distinctly different chemical functionalities onto the internal and external surfaces of mesoporous materials', Angewandte Chemie (International Edition), 47, pp. 2697 - 2699,
    Journal articles | 2008
    Kilian KA; Boecking T; Lai LH; Ilyas S; Gaus K; Gal M; Gooding JJ, 2008, 'Organic modification of mesoporous silicon rugate filters: The influence of nanoarchitecture on optical behaviour', INTERNATIONAL JOURNAL OF NANOTECHNOLOGY, 5, pp. 170 - 178
    Journal articles | 2008
    Kilian KA; Böcking T; Gaus K; Gooding JJ, 2008, 'Introducing Distinctly Different Chemical Functionalities onto the Internal and External Surfaces of Mesoporous Materials', Angewandte Chemie, 120, pp. 2737 - 2739,
    Journal articles | 2008
    Rapoport I; Boll W; Yu A; Boecking T; Kirchhausen T, 2008, 'A motif in the clathrin heavy chain required for the Hsc70/auxilin uncoating reaction', Molecular Biology of the Cell, 19, pp. 405 - 413
    Journal articles | 2008
    Salomon A; Shpaisman H; Seitz O; Boecking T; Cahen D, 2008, 'Temperature-dependent electronic transport through alkyl chain monolayers: Evidence for a molecular signature', Journal of Physical Chemistry C, 112, pp. 3969 - 3974,
    Journal articles | 2007
    Boecking T; Salomon A; Cahen D; Gooding JJ, 2007, 'Thiol-terminated monolayers on oxide-free Si: Assembly of semiconductor-alkyl-S-metal junctions', Langmuir, 23, pp. 3236 - 3241
    Journal articles | 2007
    Chilcott TC; Coster HGL; Böcking T, 2007, 'Organic-silicon interface', Biophysical Reviews and Letters, 2, pp. 191 - 205,
    Journal articles | 2007
    Ciampi S; Boecking T; Kilian KA; James M; Harper JB; Gooding JJ, 2007, 'Functionalization of acetylene-terminated monolayers on Si(100) surfaces: A click chemistry approach', Langmuir, 23, pp. 9320 - 9329,
    Journal articles | 2007
    Ilyas S; Boecking T; Kilian KA; Reece PJ; Gooding JJ; Gaus K; Gal M, 2007, 'Porous silicon based narrow line-width rugate filters', Optical Materials, 29, pp. 619 - 622,
    Journal articles | 2007
    Kilian KA; Boecking T; Gaus K; Gal M; Gooding JJ, 2007, 'Peptide-modified optical filters for detecting protease activity', ACS NANO, 1, pp. 355 - 361
    Journal articles | 2007
    Kilian KA; Boecking T; Gaus K; Gal M; Gooding JJ, 2007, 'Si-C linked oligo(ethylene glycol) layers in silicon-based photonic crystals: Optimization for implantable optical materials', Biomaterials, 28, pp. 3055 - 3062,
    Journal articles | 2007
    Kilian KA; Boecking T; Gaus K; King-Lacroix J; Gal M; Gooding JJ, 2007, 'Hybrid lipid bilayers in nanostructured silicon: a biomimetic mesoporous scaffold for optical detection of cholera toxin', Chemical Communications, pp. 1936 - 1938
    Journal articles | 2007
    Kilian KA; Ilyas S; Jessup W; Gal M; Gooding JJ; Boecking T; Gaus K, 2007, 'Forming antifouling organic multilayers on porous silicon rugate filters towards in vivo/ex vivo biophotonic devices', Advanced Functional Materials, 17, pp. 2884 - 2890,
    Journal articles | 2007
    Liu G; Boecking T; Gooding JJ, 2007, 'Diazonium salts: Stable monolayers on gold electrodes for sensing applications', Journal of Electroanalytical Chemistry, 600, pp. 335 - 344,
    Journal articles | 2007
    Salomon A; Boecking T; Seitz O; Markus T; Amy F; Chan CK; Zhao W; Cahen D; Kahn A, 2007, 'What is the barrier for tunneling through alkyl monolayers? Results from n- and p-Si-Alkyl/Hg junctions', Advanced Materials, 19, pp. 445 - 451
    Journal articles | 2006
    Amy F; Chan CK; Zhao W; Hyung J; Ono M; Sueyoshi T; Kera S; Nesher G; Salomon A; Segev L; Seitz O; Shpaisman H; Schöll A; Haeming M; Böcking T; Cahen D; Kronik L; Ueno N; Umbach E; Kahn A, 2006, 'Radiation damage to alkyl chain monolayers on semiconductor substrates investigated by electron spectroscopy', Journal of Physical Chemistry B, 110, pp. 21826 - 21832,
    Journal articles | 2006
    Bocking T; Killan KA; Gaus K; Gooding JJ, 2006, 'Single-step DNA immobilization on antifouling self-assembled monolayers covalently bound to silicon (111)', LANGMUIR, 22, pp. 3494 - 3496,
    Journal articles | 2006
    Boecking T; Kilian KA; Gaus K; Gooding JJ, 2006, 'Single-Step DNA Immobilization on Antifouling Self-Assembled Monolayers Covalently Bound to Silicon (111)', Langmuir, 22, pp. 3494 - 3496
    Journal articles | 2006
    Boecking T; Wong ELS; James M; Watson JA; Brown CL; Chilcott TC; Barrow KD; Coster HG, 2006, 'Immobilization of dendrimers on Si-C linked carboxylic acid-terminated monolayers on silicon(111)', Thin Solid Films, 515, pp. 1857 - 1863
    Journal articles | 2006
    Liu G; Nguyen QT; Chow E; Boecking T; Hibbert DB; Gooding JJ, 2006, 'Study of factors affecting the performance of voltammetric copper sensors based on Gly-Gly-His modified glassy carbon and gold electrodes', Electroanalysis, 18, pp. 1141 - 1151
    Journal articles | 2006
    Salomon A; Boecking T; Gooding JJ; Cahen D, 2006, 'How important is the interfacial chemical bond for electron transport through alkyl chain monolayers', Nano Letters, 6, pp. 2873 - 2876
    Journal articles | 2006
    Seitz O; Boecking T; Salomon A; Gooding JJ; Cahen D, 2006, 'Importance of monolayer quality for interpreting current transport through organic molecules: Alkyls on oxide-free Si', Langmuir, 22, pp. 6915 - 6922
    Journal articles | 2006
    Yu JX; Losic D; Marshall M; Boecking T; Gooding JJ; Shapter JG, 2006, 'Preparation and characterisation of an aligned carbon nanotuve array on silicon (100) surface', Soft Matter, 2, pp. 1081 - 1088
    Journal articles | 2005
    Boecking T; Gal M; Gaus K; Gooding JJ, 2005, 'Evidence for why tri(ethylene oxide) functionalized Si-C linked monolayers on Si(111) have inferior protein antifouling properties relative to the equivalent alkanethiol monolayers assembled on gold', Australian Journal of Chemistry, 58, pp. 660 - 663
    Journal articles | 2005
    Boecking T; Kilian KA; Hanley T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2005, 'The Formation of Tetraethylene Oxide Terminated Si-C Linked Monolayers and their Derivation of with Glycine: An example of a generic strategy for the modification of silicon surfaces with biomolecules', Langmuir, 21, pp. 10522 - 10529
    Journal articles | 2005
    Chou A; Singh NK; Gooding JJ; Boecking T, 2005, 'Demonstration of the importance of oxygenated species at the ends ofcarbon nanotubes for their favourable electrochemical properties', Chemical Communications, pp. 842 - 844
    Journal articles | 2005
    Chow E; Wong EL; Boecking T; Nguyen QT; Hibbert DB; Gooding JJ, 2005, 'Analytical performance and characterization of MPA-Gly-Gly-His modified sensors', Sensors and Actuators B - Chemical, 111-112, pp. 540 - 548,
    Journal articles | 2005
    Liu G; Liu J; Boecking T; Eggers PK; Gooding JJ, 2005, 'The modification of glassy carbon and gold electrodes with aryl diazonium salt: The impact of the electrode materials on the rate of heterogeneous electron transfer', Chemical physics, 319, pp. 136 - 146
    Journal articles | 2005
    Salomon A; Boecking T; Girshevitz O; Cahen D; Kahn A; Chan CK; Amy F, 2005, 'How do electronic carriers cross Si-bound alkyl monolayers?', Physical Review Letters, 95, pp. 266807 - 266810
    Journal articles | 2004
    Boecking T; Coster HG; James M; Chilcott TC; Barrow KD, 2004, 'Structural characterization of organic multilayers on silicon(111)formed by immobilization of molecular films on functionalized Si-Clinked monolayers', Langmuir, 20, pp. 9227 - 9235
    Journal articles | 2000
    Boecking T; Barrow KD; Netting AG; Chilcott TC; Coster HG; Hofer M, 2000, 'Effects of singlet oxygen on membrane sterols in the yeast Saccharomyces cerevisiae', European Journal of Biochemistry, pp. 1607 - 1618
  • Preprints | 2024
    Marzano N; Johnston B; Paudel B; Schmidberger J; Jergic S; Böcking T; Agostino M; Small I; van Oijen A; Bond C, 2024, Single-molecule visualization of sequence-specific RNA binding by a designer PPR protein,
    Preprints | 2024
    Yu R; Phalora P; Li N; Böcking T; Jacques DA, 2024, The Human T-cell Leukemia Virus capsid protein is a potential drug target,
    Preprints | 2023
    Badieyan S; Lichon D; Andreas MP; Gillies JP; Peng W; Shi J; DeSantis ME; Aiken CR; Böcking T; Giessen TW; Campbell EM; Cianfrocco MA, 2023, HIV-1 binds dynein directly to hijack microtubule transport machinery.,
    Preprints | 2023
    Dickson CF; Hertel S; Ruan J; Ariotti N; Tuckwell A; Li N; Al-Izzi SC; Sierecki E; Gambin Y; Morris RG; Towers GJ; Böcking T; Jacques DA, 2023, Karyopherin mimicry explains how the HIV capsid penetrates nuclear pores, ,
    Preprints | 2022
    Brown JWP; Alford R; Walsh J; Spinney R; Xu S; Hertel S; Berengut J; Spenkelink L; van Oijen A; Böcking T; Morris R; Lee L, 2022, Rapid exchange of stably bound protein and DNA cargo on a DNA origami receptor,
    Preprints | 2022
    Faysal KMR; Walsh JC; Renner N; Marquez CL; Shah V; Tuckwell AJ; Christie MP; Parker MW; Turville SG; James L; Towers GJ; Jacques DA; Boecking T, 2022, Pharmacologic hyperstabilisation of the HIV-1 capsid lattice induces capsid failure,
    Preprints | 2022
    Yoh SM; Mamede JI; Lau D; Ahn N; Sánchez-Aparicio MT; Temple J; Tuckwell A; Fuchs NV; Cianci GC; Riva L; Curry H; Yin X; Gambut S; Simons LM; Hultquist JF; König R; Xiong Y; García-Sastre A; Böcking T; Hope TJ; Chanda SK, 2022, Recognition of HIV-1 Capsid Licenses Innate Immune Response to Viral Infection,
    Preprints | 2022
    Zuliani Alvarez L; Govasli ML; Rasaiyaah J; Monit C; Perry SO; Sumner RP; McAlpine-Scott S; Dickson C; Faysal KMR; Hilditch L; Miles RJ; Bibollet-Ruche F; Hahn BH; Boecking T; Pinotsis N; James LC; Jacques DA; Towers GJ, 2022, Macrophage activation of cGAS and TRIM5 distinguish pandemic and non-pandemic HIV, ,
    Preprints | 2021
    Guinness CM; Walsh J; Bayly-Jones C; Dunstone M; Christie M; Christie M; Morton C; Parker M; Böcking T, 2021, Single-molecule analysis of the entire perfringolysin O pore formation pathway,
    Preprints | 2020
    Bareja I; Wioland H; Janco M; Nicovich PR; Jégou A; Romet-Lemonne G; Walsh J; Böcking T, 2020, Dynamics of Tpm1.8 domains on actin filaments with single molecule resolution,
    Preprints | 2020
    Lau D; Walsh J; Dickson C; Tuckwell A; Stear J; Hunter D; Bhumkar A; Shah V; Turville S; Sierecki E; Gambin Y; Böcking T; Jacques D, 2020, Rapid HIV-1 capsid interaction screening using fluorescence fluctuation spectroscopy,
    Conference Abstracts | 2019
    Ghosh A; Janco M; Bocking T; Gunning PW; Lehman W; Rynkiewicz MJ, 2019, 'Structure of the Tpm3.1 N-Terminus: A New Target for Anti-Cancer Treatment', in BIOPHYSICAL JOURNAL, CELL PRESS, MD, Baltimore, Vol. 116, pp. 253A - 254A, presented at 63rd Annual Meeting of the Biophysical-Society, MD, Baltimore, 02 March 2019 - 06 March 2019,
    Conference Papers | 2016
    Bhumkar A; Gambin Y; Leitao A; Bowden Q; Giles N; Francois B; Hunter D; Boecking T; Sierecki E, 2016, 'What pathological mutants tell us about synuclein aggregation pathways', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, presented at Experimental Biology Meeting, CA, San Diego, 02 April 2016 - 06 April 2016,
    Conference Papers | 2016
    Bhumkar A; Gambin Y; Leitao A; Bowden Q; Giles N; Francois B; Hunter D; Boecking T; Sierecki E, 2016, 'What pathological mutants tell us about synuclein aggregation pathways', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016,
    Conference Papers | 2016
    O'Carroll A; Ve T; Lau D; Giles N; Moustaqil M; Bhumkar A; Hunter D; Kobe B; Boecking T; Sierecki E; Gambin Y, 2016, 'Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, CA, San Diego, presented at Experimental Biology Meeting, CA, San Diego, 02 April 2016 - 06 April 2016,
    Conference Papers | 2016
    O'Carroll A; Ve T; Lau D; Giles N; Moustaqil M; Bhumkar A; Hunter D; Kobe B; Boecking T; Sierecki E; Gambin Y, 2016, 'Prion - like protein polymerisation underlies signal transduction in innate immunity: the emergence of a universal mechanism ?', in FASEB JOURNAL, FEDERATION AMER SOC EXP BIOL, San Diego, CA, presented at Experimental Biology Meeting, San Diego, CA, 02 April 2016 - 06 April 2016,
    Conference Abstracts | 2015
    Obeidy P; Sobey TL; Pandzic E; Nicovich PR; Coster A; Gunning P; Boecking T, 2015, 'Actin Tropomyosin Assembly Intermediates', in BIOPHYSICAL JOURNAL., CELL PRESS, Vol. 108, pp. 298A - 298A, presented at AACR Special Conference on Advances in Pediatric Cancer Research,
    Conference Papers | 2015
    Obeidy P; Sobey TL; Pandzic E; Nicovich PR; Coster A; Gunning P; Boecking T, 2015, 'Actin tropomyosin assembly intermediates', Baltimore (USA), pp. 298a - 298a, presented at Annual Biophysical Society Meeting, Baltimore (USA), 07 February 2015 - 11 February 2015,
    Conference Papers | 2014
    Al-Zyoud W; Hynson R; Duff A; Sobey T; Lee L; Liu D; Boecking T, 2014, 'Small-Angle X-Ray Scattering Study for Conformational Changes of Unusual Transcription Factor at the Operator', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, pp. 497A - 497A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014,
    Conference Papers | 2014
    Bowden Q; MacMillan A; Rosenkranz T; Bocking T, 2014, 'Utilising Fluorescence Microscopy to Visualise the Dynamics and Interactions of Molecular Chaperones and alpha-Synuclein', in BIOPHYSICAL JOURNAL, CELL PRESS, CA, San Francisco, pp. 492A - 492A, presented at 58th Annual Meeting of the Biophysical-Society, CA, San Francisco, 15 February 2014 - 19 February 2014,
    Conference Papers | 2010
    Kilian KA; Magenau AI; Boecking T; Gaus K; Gal M; Gooding JJ, 2010, 'Silicon-based mesoporous photonic crystals: towards single cell optical biosensors', in Biosensing II. Proceedings of SPIE Volume: 7397, SPIE, San Diego, USA, pp. 739703-1 - 739703-8, presented at SPIE Optics & Photonics, San Diego, USA, 01 August 2010 - 05 August 2010,
    Conference Papers | 2007
    Chilcott TC; Wong ELS; Böcking T; Coster HGL, 2007, 'Probing biomimetic molecular structures on gold and silicon(111) with electrical impedance spectroscopy', in IFMBE Proceedings, pp. 308 - 311,
    Conference Papers | 2007
    Gooding JJ; Chou A; Boecking T; Hibbert DB; Yu J; Losic D; Shapter JG, 2007, 'The electrochemical performance of electrodes modified with carbon nanotubes', in Joint Symposium of Fundamental Aspects of Nanostructured Materials and Electrocatalysis, Saspporo, Japan, pp. 22 - 23, presented at Joint Symposium of Fundamental Aspects of Nanostructured Materials and Electrocatalysis, Saspporo, Japan, 02 June 2007 - 23 June 2007
    Conference Papers | 2007
    Kilian KA; Boecking T; Ciampi S; Gaus K; Gal M; Gooding JJ, 2007, 'The modification of flat and porous silicon surface with organic monolayers for the capture and detection of biomolecules', in Quake S; Heath JR (ed.), Keystone Symposium on Nanotechnology in Biomedicine, USA, pp. 46 - 46, presented at Keystone Symposium on Nanotechnology in Biomedicine, Tahoe City, USA, 11 February 2007 - 16 February 2007
    Conference Abstracts | 2007
    Kilian KA; Lai LMH; Boecking T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2007, 'Covalently bound biopolymers within mesoporous silicon as improved substrates for optical detection of enzyme activity', in ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, AMER CHEMICAL SOC, IL, Chicago, Vol. 233, pp. 62 - 62, presented at 233rd National Meeting of the Cellulose-and-Renewable-Materials-Division of the American-Chemical-Society (ACS), IL, Chicago, 25 March 2007 - 29 March 2007,
    Conference Papers | 2007
    Yu JX; Losic D; Marshall M; Boecking T; Gooding JJ; Shapter JG, 2007, 'Preparation and characterisation of an aligned carbon nanotube array on silicon (100) surface', in RACI Organic and Physical Chemistry Conference, Adelaide, Sth Aust, pp. PC30 - PC30, presented at RACI Organic and Physical Chemistry Conference, Adelaide, Sth Aust, 28 January 2007 - 02 February 2007
    Conference Papers | 2006
    Kilian KA; Bocking T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2006, 'Optimisation of Nanostructured Porous Silicon Surface Chemistry Towards Biophotonic Sensors', in 2006 INTERNATIONAL CONFERENCE ON NANOSCIENCE AND NANOTECHNOLOGY, VOLS 1 AND 2, IEEE, AUSTRALIA, Brisbane, pp. 671 - +, presented at International Conference on Nanoscience and Nanotechnology, AUSTRALIA, Brisbane, 03 July 2006 - 07 July 2006,
    Conference Papers | 2006
    Kilian KA; Boecking T; Ilyas S; Gal M; Gaus K; Gooding JJ, 2006, 'Optimisation of Nanstructured Porous Silicon Surface Chemistry Towards Biophotonic Sensors', in Jagadirh J; Lu M (ed.), International Conference on Nanoscience and Nanotechnology, Brisbane, Qld, pp. 193 - 193, presented at ICONN 2006: International Conference on Nanoscience and Nanotechnology, Brisbane, Qld, 03 July 2006 - 07 July 2006
    Conference Papers | 2006
    Kilian KA; Böcking T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2006, 'Optimisation of nanostructured porous silicon surface chemistry towards biophotonic sensors', in Proceedings of the 2006 International Conference on Nanoscience and Nanotechnology, ICONN, pp. 486 - 489,
    Conference Papers | 2005
    Boecking T; Ilyas S; Kilian KA; Salvador GP; Reece PJ; Gaus K; Gal M; Gooding JJ, 2005, 'Covalent modification of flat single crystal and porous silicon surfaces for biosensor applications', in Australian Colloid Interface Science Conference 2005, Coogee, NSW, pp. 149 - 149, presented at Australian Colloid Interface Science Conference 2005, Coogee, NSW, 13 February 2005 - 17 February 2005
    Conference Papers | 2005
    Böcking T; Ilyas S; Salvador GP; Reece PJ; Gaus K; Gooding JJ; Gal M, 2005, 'Functionalization of porous silicon based photonic crystals with organic monolayers', in Conference on Optoelectronic and Microelectronic Materials and Devices, Proceedings, COMMAD, pp. 217 - 220,
    Conference Papers | 2005
    Gooding JJ; Chou A; Liu J; Boecking T; Singh NK; Hibbert DB; Losic D; Shapter JG, 2005, 'The Self-Assembly of Aligned Carbon Nanotube Arrays for Communicating with Proteins', in Australian Colloid Interface Science Conference 2005, Coogee, NSW, pp. 85 - -, presented at Australian Colloid Interface Science Conference 2005, Coogee, NSW, 13 February 2005 - 17 February 2005
    Conference Papers | 2005
    Ilyas S; Reece PJ; Salvador GP; Böcking T; Gal M, 2005, 'Porous silicon based rugate filters', in Conference on Optoelectronic and Microelectronic Materials and Devices, Proceedings, COMMAD, pp. 169 - 172,
    Conference Papers | 2005
    Kilian KA; Boecking T; Ilyas S; Gaus K; Gal M; Gooding JJ, 2005, 'Organic Modification of Porous Silicon Photonic Crystals for Biological Sensing Applications', in Apte S; Kable S; Baker AT (eds.), Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, pp. M026 PO Bi/Or - na, presented at Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, 03 July 2005 - 07 July 2005
    Conference Papers | 2005
    Singh NK; Boecking T, 2005, 'Formation of organic monolayers on hydrogen-terminated silicon surfaces via silicon-carbon bond: effect of terminal groups on stability', in 16th National Congress: Physics for the Nation, Australian National University, Canberra, presented at 16th National Congress: Physics for the Nation, Australian National University, Canberra, 30 January 2005 - 04 February 2005
    Conference Proceedings (Editor of) | 2005
    Singh NK; Liu R; Boecking T; Gooding JJ, (eds.), 2005, 'Connect 2005 - Chemical Challenges for the 21st Century', Sydney, Convention Centre, Darling Harbour, Sydney, presented at Connect 2005 - Chemical Challenges for the 21st Century, Sydney, Convention Centre, Darling Harbour, Sydney, 03 July 2005 - 07 July 2005
    Conference Papers | 2003
    Boecking T; Chilcott TC; Coster HG; Barrow KD; James M, 2003, 'Organic monolayers on silicon: electrical impedance spectroscopy methodology towards studying bilayers on silicon', in 5th International Membrane Science and Technology Conference (IMSTEC 03), University of New South Wales, Sydney, Australia, pp. 1 - 6, presented at 5th International Membrane Science and Technology Conference (IMSTEC 03), University of New South Wales, Sydney, Australia, 10 November 2003 - 14 November 2003
    Conference Presentations | 1999
    Chilcott TC; Coster HG; Boecking T; Barrow KD; Hofer M, 1999, 'Implications for membrane structure and function of singlet oxygen mediated oxidation of membrane sterols in the yeast `Saccharomyces cerevisiae`', presented at 23rd Annual Meeting of the Australian Society for Biophysics, Gold Coast, Qld, 30 September 1999

  • 2011-2014 ARC Future Fellowship
  • 2011-2014 NHMRC Career Development Award (honorary)
  • 2009 Young Investigator Award Lorne Protein Conference
  • Young Biophysicist Award of the Australian Society for Biophysics
  • 2007–2010 HFSP Cross-Disciplinary Fellowship (3 years)
  • 2007 Federation of the European Biochemical Societies (FEBS) Youth Travel Fund Grant
  • 2001–2003 UNSW Faculty of Science Scholarship
  • 2001–2003 Australian Institute for Nuclear Science and Engineering (AINSE) Postgraduate Award
  • 2000–2003 International Postgraduate Research Scholarship (IPRS)
  • 1996 Deutscher Akademischer Austauschdienst (DAAD) Scholarship

  • Australian Society for Biochemistry and Molecular Biology (ASBMB)
  • Australian Society for Biophysics (ASB)

My Research Supervision

PhD students: Chantal Marquez, Ilina Bareja, Derrick Lau, KM Rifat Faysal, Wang Peng, Conall McGuinness

Honours students: Shivani Shah

My Teaching

ANAT3212